PANTHER Pathway  >   Integrin signalling pathway >   Mitogen-activated protein kinase kinase

Pathway Component Details   
Name: Mitogen-activated protein kinase kinase (MEK)
Definition: MEK is a serine/threonine kinase which is a member of the MAPK pathway. External signals lead Raf, a MAPKKK, to phosphorylate and activate MEK. MEK then phosphorylates and activates ERK.
Category ID: P00925
Synonyms:
Upstream: B-Raf
Raf Oncogene  (Raf)
Downstream: Extracellular signal-regulated kinase  (ERK)
Number Families/Subfamilies: 5
Number of Associated Sequences: 25
GO Molecular Function: -
GO Biological Process: -
GO Cellular Component: -
PANTHER protein class: -
References:

Sequence Association
Panther Subfamily Associated Sequence Definition Confidence Code Evidence
PTHR48013:SF15 A0A1D5QAU9 Mitogen-activated protein kinase kinase 4 ISS PubMed:10207617  
  A0A1D5QAU9 Mitogen-activated protein kinase kinase 4 ISS PubMed:11730323  
  A0A1D5QAU9 Mitogen-activated protein kinase kinase 4 ISS PubMed:12040174  
  A0A1D5QAU9 Mitogen-activated protein kinase kinase 4 ISS PubMed:7716521  
  A0A3Q1N7I1 Mitogen-activated protein kinase kinase 4 ISS PubMed:10207617  
  A0A3Q1N7I1 Mitogen-activated protein kinase kinase 4 ISS PubMed:11730323  
  A0A3Q1N7I1 Mitogen-activated protein kinase kinase 4 ISS PubMed:12040174  
  A0A3Q1N7I1 Mitogen-activated protein kinase kinase 4 ISS PubMed:7716521  
  B1NA68 Dual specificity mitogen-activated protein kinase kinase 4 ISS PubMed:10207617  
  B1NA68 Dual specificity mitogen-activated protein kinase kinase 4 ISS PubMed:11730323  
  B1NA68 Dual specificity mitogen-activated protein kinase kinase 4 ISS PubMed:12040174  
  B1NA68 Dual specificity mitogen-activated protein kinase kinase 4 ISS PubMed:7716521  
  O61444 MAP kinase kinase 4, isoform A IDA PubMed:11730323  
  O61444 MAP kinase kinase 4, isoform A IDA PubMed:12040174  
  O61444 MAP kinase kinase 4, isoform A IDA PubMed:7600581  
  P47809 Dual specificity mitogen-activated protein kinase kinase 4 ISS PubMed:10207617  
  P47809 Dual specificity mitogen-activated protein kinase kinase 4 ISS PubMed:11730323  
  P47809 Dual specificity mitogen-activated protein kinase kinase 4 ISS PubMed:12040174  
PTHR48013:SF21 A0A3Q1MNG1 Mitogen-activated protein kinase kinase 3 ISS PubMed:10207617  
  A0A3Q1MNG1 Mitogen-activated protein kinase kinase 3 ISS PubMed:11730323  
  A0A3Q1MNG1 Mitogen-activated protein kinase kinase 3 ISS PubMed:8900184  
  A0A6I8PHX7 Mitogen-activated protein kinase kinase 3 ISS PubMed:11730323  
  A0A6I8PHX7 Mitogen-activated protein kinase kinase 3 ISS PubMed:11971971  
  A0A6I8PHX7 Mitogen-activated protein kinase kinase 3 ISS PubMed:8900184  
  A0A6I8PHX7 Mitogen-activated protein kinase kinase 3 ISS PubMed:97059154  
  M0R7E7 Mitogen activated protein kinase kinase 3 ISS PubMed:10207617  
  M0R7E7 Mitogen activated protein kinase kinase 3 ISS PubMed:11730323  
  M0R7E7 Mitogen activated protein kinase kinase 3 ISS PubMed:8900184  
  O09110 Dual specificity mitogen-activated protein kinase kinase 3 IDA PubMed:10207617  
  O09110 Dual specificity mitogen-activated protein kinase kinase 3 IDA PubMed:11730323  
  O09110 Dual specificity mitogen-activated protein kinase kinase 3 IDA PubMed:8900184  
  P46734 Dual specificity mitogen-activated protein kinase kinase 3 ISS PubMed:10207617  
  P46734 Dual specificity mitogen-activated protein kinase kinase 3 ISS PubMed:11730323  
  P46734 Dual specificity mitogen-activated protein kinase kinase 3 ISS PubMed:8900184  
PTHR48013:SF29 H2QCA7 Mitogen-activated protein kinase kinase 4 ISS PubMed:10207617  
  H2QCA7 Mitogen-activated protein kinase kinase 4 ISS PubMed:11730323  
  H2QCA7 Mitogen-activated protein kinase kinase 4 ISS PubMed:12040174  
  H2QCA7 Mitogen-activated protein kinase kinase 4 ISS PubMed:7716521  
  P45985 Dual specificity mitogen-activated protein kinase kinase 4 IDA PubMed:10207617  
  P45985 Dual specificity mitogen-activated protein kinase kinase 4 IDA PubMed:11730323  
  P45985 Dual specificity mitogen-activated protein kinase kinase 4 IDA PubMed:12040174  
  P45985 Dual specificity mitogen-activated protein kinase kinase 4 IDA PubMed:7716521  
PTHR48013:SF5 F6XT65 Mitogen-activated protein kinase kinase 1 ISS PubMed:10395662  
  F6XT65 Mitogen-activated protein kinase kinase 1 ISS PubMed:11238629  
  F6XT65 Mitogen-activated protein kinase kinase 1 ISS PubMed:11730323  
  F6XT65 Mitogen-activated protein kinase kinase 1 ISS PubMed:12876277  
  F6XT65 Mitogen-activated protein kinase kinase 1 ISS 13928886  
  F6XT65 Mitogen-activated protein kinase kinase 1 ISS PubMed:1411546  
  F6XT65 Mitogen-activated protein kinase kinase 1 ISS PubMed:1499729  
  F6XT65 Mitogen-activated protein kinase kinase 1 ISS OMIM:176872  
  F6XT65 Mitogen-activated protein kinase kinase 1 ISS PubMed:8039496  
  F6XT65 Mitogen-activated protein kinase kinase 1 ISS PubMed:8157000  
  F6XT65 Mitogen-activated protein kinase kinase 1 ISS PubMed:8388392  
  F6XT65 Mitogen-activated protein kinase kinase 1 ISS PubMed:8394352  
  F6XT65 Mitogen-activated protein kinase kinase 1 ISS PubMed:92362878  
  F6XT65 Mitogen-activated protein kinase kinase 1 ISS PubMed:93178455  
  F6XT65 Mitogen-activated protein kinase kinase 1 ISS PubMed:94313981  
  F7C389 Dual specificity mitogen-activated protein kinase kinase 1 ISS PubMed:10395662  
  F7C389 Dual specificity mitogen-activated protein kinase kinase 1 ISS PubMed:11238629  
  F7C389 Dual specificity mitogen-activated protein kinase kinase 1 ISS PubMed:11730323  
  F7C389 Dual specificity mitogen-activated protein kinase kinase 1 ISS PubMed:12876277  
  F7C389 Dual specificity mitogen-activated protein kinase kinase 1 ISS 13928886  
  F7C389 Dual specificity mitogen-activated protein kinase kinase 1 ISS PubMed:1411546  
  F7C389 Dual specificity mitogen-activated protein kinase kinase 1 ISS PubMed:1499729  
  F7C389 Dual specificity mitogen-activated protein kinase kinase 1 ISS OMIM:176872  
  F7C389 Dual specificity mitogen-activated protein kinase kinase 1 ISS PubMed:8039496  
  F7C389 Dual specificity mitogen-activated protein kinase kinase 1 ISS PubMed:8157000  
  F7C389 Dual specificity mitogen-activated protein kinase kinase 1 ISS PubMed:8388392  
  F7C389 Dual specificity mitogen-activated protein kinase kinase 1 ISS PubMed:8394352  
  F7C389 Dual specificity mitogen-activated protein kinase kinase 1 ISS PubMed:92362878  
  F7C389 Dual specificity mitogen-activated protein kinase kinase 1 ISS PubMed:93178455  
  P31938 Dual specificity mitogen-activated protein kinase kinase 1 ISS PubMed:10395662  
  P31938 Dual specificity mitogen-activated protein kinase kinase 1 ISS PubMed:11238629  
  P31938 Dual specificity mitogen-activated protein kinase kinase 1 ISS PubMed:11730323  
  P31938 Dual specificity mitogen-activated protein kinase kinase 1 ISS PubMed:12876277  
  P31938 Dual specificity mitogen-activated protein kinase kinase 1 ISS 13928886  
  P31938 Dual specificity mitogen-activated protein kinase kinase 1 ISS PubMed:1411546  
  P31938 Dual specificity mitogen-activated protein kinase kinase 1 ISS PubMed:1499729  
  P31938 Dual specificity mitogen-activated protein kinase kinase 1 ISS OMIM:176872  
  P31938 Dual specificity mitogen-activated protein kinase kinase 1 ISS PubMed:8039496  
  P31938 Dual specificity mitogen-activated protein kinase kinase 1 ISS PubMed:8388392  
  P31938 Dual specificity mitogen-activated protein kinase kinase 1 ISS PubMed:92362878  
  P31938 Dual specificity mitogen-activated protein kinase kinase 1 ISS PubMed:93178455  
  P31938 Dual specificity mitogen-activated protein kinase kinase 1 ISS PubMed:94313981  
  Q01986 Dual specificity mitogen-activated protein kinase kinase 1 IDA PubMed:10395662  
  Q01986 Dual specificity mitogen-activated protein kinase kinase 1 IDA PubMed:11238629  
  Q01986 Dual specificity mitogen-activated protein kinase kinase 1 IDA PubMed:11730323  
  Q01986 Dual specificity mitogen-activated protein kinase kinase 1 IDA PubMed:12876277  
  Q01986 Dual specificity mitogen-activated protein kinase kinase 1 IDA 13928886  
  Q01986 Dual specificity mitogen-activated protein kinase kinase 1 IDA OMIM:176872  
  Q01986 Dual specificity mitogen-activated protein kinase kinase 1 IDA PubMed:8039496  
  Q01986 Dual specificity mitogen-activated protein kinase kinase 1 IDA PubMed:8157000  
  Q01986 Dual specificity mitogen-activated protein kinase kinase 1 IDA PubMed:8388392  
  Q01986 Dual specificity mitogen-activated protein kinase kinase 1 IDA PubMed:8394352  
  Q02750 Dual specificity mitogen-activated protein kinase kinase 1 IDA PubMed:10395662  
  Q02750 Dual specificity mitogen-activated protein kinase kinase 1 IDA PubMed:11238629  
  Q02750 Dual specificity mitogen-activated protein kinase kinase 1 IDA PubMed:11730323  
  Q02750 Dual specificity mitogen-activated protein kinase kinase 1 IDA OMIM:176872  
  Q02750 Dual specificity mitogen-activated protein kinase kinase 1 IDA PubMed:8039496  
  Q02750 Dual specificity mitogen-activated protein kinase kinase 1 IDA PubMed:8388392  
  Q02750 Dual specificity mitogen-activated protein kinase kinase 1 IDA PubMed:93178455  
  Q0VD16 MAP2K1 protein ISS PubMed:10395662  
  Q0VD16 MAP2K1 protein ISS PubMed:11238629  
  Q0VD16 MAP2K1 protein ISS PubMed:11730323  
  Q0VD16 MAP2K1 protein ISS PubMed:12876277  
  Q0VD16 MAP2K1 protein ISS 13928886  
  Q0VD16 MAP2K1 protein ISS PubMed:1411546  
  Q0VD16 MAP2K1 protein ISS PubMed:1499729  
  Q0VD16 MAP2K1 protein ISS OMIM:176872  
  Q0VD16 MAP2K1 protein ISS PubMed:8039496  
  Q0VD16 MAP2K1 protein ISS PubMed:8157000  
  Q0VD16 MAP2K1 protein ISS PubMed:8388392  
  Q0VD16 MAP2K1 protein ISS PubMed:8394352  
  Q0VD16 MAP2K1 protein ISS PubMed:92362878  
  Q0VD16 MAP2K1 protein ISS PubMed:93178455  
  Q9XT09 Dual specificity mitogen-activated protein kinase kinase 1 ISS PubMed:10395662  
  Q9XT09 Dual specificity mitogen-activated protein kinase kinase 1 ISS PubMed:11238629  
  Q9XT09 Dual specificity mitogen-activated protein kinase kinase 1 ISS PubMed:11730323  
  Q9XT09 Dual specificity mitogen-activated protein kinase kinase 1 ISS PubMed:12876277  
  Q9XT09 Dual specificity mitogen-activated protein kinase kinase 1 ISS 13928886  
  Q9XT09 Dual specificity mitogen-activated protein kinase kinase 1 ISS PubMed:1499729  
  Q9XT09 Dual specificity mitogen-activated protein kinase kinase 1 ISS OMIM:176872  
  Q9XT09 Dual specificity mitogen-activated protein kinase kinase 1 ISS PubMed:8039496  
  Q9XT09 Dual specificity mitogen-activated protein kinase kinase 1 ISS PubMed:8388392  
  Q9XT09 Dual specificity mitogen-activated protein kinase kinase 1 ISS PubMed:92362878  
  Q9XT09 Dual specificity mitogen-activated protein kinase kinase 1 ISS PubMed:93178455  
PTHR48013:SF8 K7BYT0 Mitogen-activated protein kinase kinase 2 ISS PubMed:10395662  
  K7BYT0 Mitogen-activated protein kinase kinase 2 ISS PubMed:11238629  
  K7BYT0 Mitogen-activated protein kinase kinase 2 ISS PubMed:11730323  
  K7BYT0 Mitogen-activated protein kinase kinase 2 ISS OMIM:176872  
  K7BYT0 Mitogen-activated protein kinase kinase 2 ISS 18959214  
  K7BYT0 Mitogen-activated protein kinase kinase 2 ISS PubMed:8380494  
  K7BYT0 Mitogen-activated protein kinase kinase 2 ISS PubMed:8388392  
  K7BYT0 Mitogen-activated protein kinase kinase 2 ISS PubMed:8393135  
  K7BYT0 Mitogen-activated protein kinase kinase 2 ISS PubMed:9398267  
  K7BYT0 Mitogen-activated protein kinase kinase 2 ISS PubMed:98060792  
  P36506 Dual specificity mitogen-activated protein kinase kinase 2 IDA PubMed:10395662  
  P36506 Dual specificity mitogen-activated protein kinase kinase 2 IDA PubMed:11238629  
  P36506 Dual specificity mitogen-activated protein kinase kinase 2 IDA PubMed:11730323  
  P36506 Dual specificity mitogen-activated protein kinase kinase 2 IDA OMIM:176872  
  P36506 Dual specificity mitogen-activated protein kinase kinase 2 IDA 18959214  
  P36506 Dual specificity mitogen-activated protein kinase kinase 2 IDA PubMed:8380494  
  P36506 Dual specificity mitogen-activated protein kinase kinase 2 IDA PubMed:8393135  
  P36507 Dual specificity mitogen-activated protein kinase kinase 2 IDA PubMed:10395662  
  P36507 Dual specificity mitogen-activated protein kinase kinase 2 IDA PubMed:11238629  
  P36507 Dual specificity mitogen-activated protein kinase kinase 2 IDA PubMed:11730323  
  P36507 Dual specificity mitogen-activated protein kinase kinase 2 IDA OMIM:176872  
  P36507 Dual specificity mitogen-activated protein kinase kinase 2 IDA 18959214  
  P36507 Dual specificity mitogen-activated protein kinase kinase 2 IDA PubMed:8380494  
  P36507 Dual specificity mitogen-activated protein kinase kinase 2 IDA PubMed:8388392  
  P36507 Dual specificity mitogen-activated protein kinase kinase 2 IDA PubMed:8393135  
  P36507 Dual specificity mitogen-activated protein kinase kinase 2 IDA PubMed:98060792  
  Q1HG70 Dual specificity mitogen-activated protein kinase kinase 2 ISS PubMed:10395662  
  Q1HG70 Dual specificity mitogen-activated protein kinase kinase 2 ISS PubMed:11238629  
  Q1HG70 Dual specificity mitogen-activated protein kinase kinase 2 ISS PubMed:11730323  
  Q1HG70 Dual specificity mitogen-activated protein kinase kinase 2 ISS OMIM:176872  
  Q1HG70 Dual specificity mitogen-activated protein kinase kinase 2 ISS 18959214  
  Q1HG70 Dual specificity mitogen-activated protein kinase kinase 2 ISS PubMed:8380494  
  Q1HG70 Dual specificity mitogen-activated protein kinase kinase 2 ISS PubMed:8388392  
  Q1HG70 Dual specificity mitogen-activated protein kinase kinase 2 ISS PubMed:8393135  
  Q1HG70 Dual specificity mitogen-activated protein kinase kinase 2 ISS PubMed:9398267  
  Q1HG70 Dual specificity mitogen-activated protein kinase kinase 2 ISS PubMed:98060792  
  Q63932 Dual specificity mitogen-activated protein kinase kinase 2 IDA PubMed:10395662  
  Q63932 Dual specificity mitogen-activated protein kinase kinase 2 IDA PubMed:11238629  
  Q63932 Dual specificity mitogen-activated protein kinase kinase 2 IDA PubMed:11730323  
  Q63932 Dual specificity mitogen-activated protein kinase kinase 2 IDA OMIM:176872  
  Q63932 Dual specificity mitogen-activated protein kinase kinase 2 IDA 18959214  
  Q63932 Dual specificity mitogen-activated protein kinase kinase 2 IDA PubMed:8380494  
  Q63932 Dual specificity mitogen-activated protein kinase kinase 2 IDA PubMed:8393135  
  Q63932 Dual specificity mitogen-activated protein kinase kinase 2 IDA PubMed:98060792  
  Q90891 Dual specificity mitogen-activated protein kinase kinase 2 IDA PubMed:10395662  
  Q90891 Dual specificity mitogen-activated protein kinase kinase 2 IDA PubMed:11238629  
  Q90891 Dual specificity mitogen-activated protein kinase kinase 2 IDA PubMed:11730323  
  Q90891 Dual specificity mitogen-activated protein kinase kinase 2 IDA OMIM:176872  
  Q90891 Dual specificity mitogen-activated protein kinase kinase 2 IDA PubMed:8380494  
  Q90891 Dual specificity mitogen-activated protein kinase kinase 2 IDA PubMed:8388392  
  Q90891 Dual specificity mitogen-activated protein kinase kinase 2 IDA PubMed:8393135  
  Q90891 Dual specificity mitogen-activated protein kinase kinase 2 IDA PubMed:9398267  
  Q90891 Dual specificity mitogen-activated protein kinase kinase 2 IDA PubMed:98060792