PANTHER Pathway  >   Nicotinic acetylcholine receptor signaling pathway >   choline acetyltransferase

Pathway Component Details   
Name: choline acetyltransferase (CAT)
Definition: Choline acetyltransferase (ChAT), the enzyme responsible for the biosynthesis of acetylcholine, is presently the most specific indicator for monitoring the functional state of cholinergic neurones in the central and peripheral nervous systems. ChAT is a single-strand globular protein. The enzyme is synthesized in the perikaryon of cholinergic neurones and transported to the nerve terminals probably by both slow and rapid axoplasmic flows. ChAT exists in at least two forms in cholinergic nerve terminals: (i) soluble; and (ii) non-ionically membrane-bound forms. Multiple mRNA species of ChAT (R-, N-and M-types) are transcribed from different promoter regions and produced by different splicing in the mouse, rat, and human. All transcripts encode the same ChAT protein in rodents, while in human M-type mRNA has the capability to generate both large and small forms of ChAT proteins and R-and N-types ChAT mRNA generate a small form, which corresponds to the rodent ChAT.
Category ID: P01087
Synonyms:
Upstream:
Downstream:
Number Families/Subfamilies: 2
Number of Associated Sequences: 13
GO Molecular Function: -
GO Biological Process: -
GO Cellular Component: -
PANTHER protein class: -
References: Medline:10594838  Medline:12401548  http://www.genome.ad.jp/dbget-bin/www_bget?hsa:1103 

Sequence Association
Panther Subfamily Associated Sequence Definition Confidence Code Evidence
PTHR22589:SF103 Q17499 Choline_carnitine acyltransferase domain-containing protein ISS  
PTHR22589:SF14 A0A1S4GEW3 Choline_carnitine acyltransferase domain-containing protein IC PubMed:92155737  
  A0A1S4GEW3 Choline_carnitine acyltransferase domain-containing protein IC PubMed:97225904  
  A0A8I3PDE8 Choline O-acetyltransferase ISS PubMed:92155737  
  A0A8I3PDE8 Choline O-acetyltransferase ISS PubMed:97225904  
  A8X694 Protein CBR-CHA-1 ISS PubMed:92155737  
  A8X694 Protein CBR-CHA-1 ISS PubMed:97225904  
  F1MLQ5 Choline O-acetyltransferase ISS PubMed:92155737  
  F1MLQ5 Choline O-acetyltransferase ISS PubMed:97225904  
  F6RM01 Choline O-acetyltransferase ISS PubMed:92155737  
  F6RM01 Choline O-acetyltransferase ISS PubMed:97225904  
  H2RAF8 Choline O-acetyltransferase ISS PubMed:92155737  
  H2RAF8 Choline O-acetyltransferase ISS PubMed:97225904  
  P07668 Choline O-acetyltransferase IC PubMed:92155737  
  P07668 Choline O-acetyltransferase IC PubMed:97225904  
  P28329 Choline O-acetyltransferase IC PubMed:92155737  
  P32738 Choline O-acetyltransferase IC PubMed:92155737  
  P32756 Choline O-acetyltransferase ISS PubMed:92155737  
  P32756 Choline O-acetyltransferase ISS PubMed:97225904  
  Q03059 Choline O-acetyltransferase IC PubMed:92155737  
  Q90YJ9 Choline O-acetyltransferase IC PubMed:92155737