Pathway Component Details
| Name: | Parkin |
| Definition: | Parkin is a ring-finger domain-containing protein that acts as an E3 ligase in the ubiquitination of substrates for degradation by the proteasome. Parkin was linked to Parkinson's disease by the discovery of autosomal recessive mutations responsible for juvenile-onset Parkinson's. |
| Category ID: | P01216 |
| Synonyms: | |
| Upstream: | |
| Downstream: | |
| Number Families/Subfamilies: | 1 |
| Number of Associated Sequences: | 4 |
| GO Molecular Function: |
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| GO Biological Process: |
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| GO Cellular Component: |
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| PANTHER protein class: |
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| References: |
Sequence Association
| Panther Subfamily | Associated Sequence | Definition | Confidence Code | Evidence |
| PTHR11685:SF448 | F6U1L3 | E3 ubiquitin-protein ligase parkin | ISS | PubMed:11078524 |
| H2QU08 | E3 ubiquitin-protein ligase parkin | ISS | PubMed:11078524 | |
| O60260 | E3 ubiquitin-protein ligase parkin | IDA | PubMed:11078524 | |
| Q9WVS6 | E3 ubiquitin-protein ligase parkin | IDA | PubMed:11078524 |
