Pathway Component Details
| Name: | 20S proteasome |
| Definition: | The 20S proteasomal subunit forms a complex with the 19S subunit to form the active degradative unit. This complex can degrade many ubiquitinated proteins within this pathway, including synuclein, synphilin, CDCRel bound to parkin, tyrosine hydroxylase bound to parkin, Pael-R bound to parkin, and cyclin E. |
| Category ID: | P01227 |
| Synonyms: | |
| Upstream: | |
| Downstream: | |
| Number Families/Subfamilies: | 25 |
| Number of Associated Sequences: | 195 |
| GO Molecular Function: |
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| GO Biological Process: |
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| GO Cellular Component: |
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| PANTHER protein class: |
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| References: |
Sequence Association
| Panther Subfamily | Associated Sequence | Definition | Confidence Code | Evidence |
| PTHR11599:SF10 | A0A8I3PDR8 | Proteasome 20S subunit alpha 3 | ISS | PubMed:12859888 |
| D6XCY8 | Proteasome alpha 7 subunit | ISS | PubMed:12859888 | |
| F7ETB2 | Proteasome subunit alpha type | ISS | PubMed:12859888 | |
| H2Q8D7 | Proteasome subunit alpha type | ISS | PubMed:12859888 | |
| O23715 | Proteasome subunit alpha type-3 | ISS | PubMed:12859888 | |
| O59770 | Probable proteasome subunit alpha type-7 | TAS | PubMed:12859888 | |
| O70435 | Proteasome subunit alpha type-3 | TAS | PubMed:12859888 | |
| P18422 | Proteasome subunit alpha type-3 | TAS | PubMed:12859888 | |
| P21242 | Probable proteasome subunit alpha type-7 | TAS | PubMed:12859888 | |
| P25788 | Proteasome subunit alpha type-3 | TAS | PubMed:12859888 | |
| Q27563 | Proteasome subunit alpha type-3 | TAS | PubMed:12859888 | |
| Q58DU5 | Proteasome subunit alpha type-3 | ISS | PubMed:12859888 | |
| Q5ZLI2 | Proteasome subunit alpha type | ISS | PubMed:12859888 | |
| Q9LSU0 | Proteasome subunit alpha type-3 | TAS | PubMed:12859888 | |
| Q9V5C6 | Proteasome subunit alpha type-3 | TAS | PubMed:12859888 | |
| PTHR11599:SF11 | A0A8I3N0P1 | Proteasome subunit alpha type | ISS | PubMed:12859888 |
| A8WY28 | Proteasome subunit alpha type | ISS | PubMed:12859888 | |
| E9AFW0 | Proteasome subunit alpha type | ISS | PubMed:12859888 | |
| F7C9K3 | Proteasome subunit alpha type | ISS | PubMed:12859888 | |
| F7DYR4 | Proteasome subunit alpha type | ISS | PubMed:12859888 | |
| G2HIX7 | Proteasome subunit alpha type | ISS | PubMed:12859888 | |
| H9YZY1 | Proteasome subunit alpha type | ISS | PubMed:12859888 | |
| O17586 | Proteasome subunit alpha type-6 | TAS | PubMed:12859888 | |
| O81147 | Proteasome subunit alpha type-6-B | TAS | PubMed:12859888 | |
| O94517 | Probable proteasome subunit alpha type-1 | TAS | PubMed:12859888 | |
| P21243 | Proteasome subunit alpha type-1 | TAS | PubMed:12859888 | |
| P60900 | Proteasome subunit alpha type-6 | TAS | PubMed:12859888 | |
| P60901 | Proteasome subunit alpha type-6 | TAS | PubMed:12859888 | |
| Q2YDE4 | Proteasome subunit alpha type-6 | ISS | PubMed:12859888 | |
| Q7Q2B0 | Proteasome subunit alpha type | TAS | PubMed:12859888 | |
| Q9LSU3 | Proteasome subunit alpha type-6 | TAS | PubMed:12859888 | |
| Q9QUM9 | Proteasome subunit alpha type-6 | TAS | PubMed:12859888 | |
| Q9XZJ4 | Proteasome subunit alpha type-6 | TAS | PubMed:12859888 | |
| PTHR11599:SF110 | Q7SXN6 | Proteasome subunit alpha type | ISS | PubMed:12859888 |
| PTHR11599:SF113 | Q6GQM3 | Proteasome subunit alpha type | TAS | PubMed:12859888 |
| PTHR11599:SF12 | A0A8I3PX29 | Proteasome subunit alpha type | ISS | PubMed:12859888 |
| A8X995 | Proteasome subunit alpha type | ISS | PubMed:12859888 | |
| F0Z724 | Proteasome subunit alpha type | ISS | PubMed:12859888 | |
| F6XAZ1 | Proteasome subunit alpha type | ISS | PubMed:12859888 | |
| F7FBS3 | Proteasome subunit alpha type | ISS | PubMed:12859888 | |
| O14250 | Probable proteasome subunit alpha type-6 | TAS | PubMed:12859888 | |
| O42265 | Proteasome subunit alpha type-1 | ISS | PubMed:12859888 | |
| O44156 | Proteasome subunit alpha type-1 | TAS | PubMed:12859888 | |
| P12881 | Proteasome subunit alpha type-1 | TAS | PubMed:12859888 | |
| P18420 | Proteasome subunit alpha type-1 | ISS | PubMed:12859888 | |
| P25786 | Proteasome subunit alpha type-1 | ISS | PubMed:12859888 | |
| P40302 | Proteasome subunit alpha type-6 | TAS | PubMed:12859888 | |
| P52428 | Proteasome subunit alpha type-1 | TAS | PubMed:12859888 | |
| Q27562 | Proteasome subunit alpha type-1 | TAS | PubMed:12859888 | |
| Q38B02 | Proteasome subunit alpha type | ISS | PubMed:12859888 | |
| Q3T0X5 | Proteasome subunit alpha type-1 | ISS | PubMed:12859888 | |
| Q6DGX8 | Proteasome subunit alpha type | ISS | PubMed:12859888 | |
| Q7PMD7 | Proteasome subunit alpha type | TAS | PubMed:12859888 | |
| Q9R1P4 | Proteasome subunit alpha type-1 | ISS | PubMed:12859888 | |
| Q9VK14 | Proteasome subunit alpha type | TAS | PubMed:12859888 | |
| PTHR11599:SF13 | E2RTW7 | 20S proteasome alpha subunit 3 | TAS | PubMed:12859888 |
| F0ZYX2 | Proteasome subunit alpha type | ISS | PubMed:12859888 | |
| F6Z866 | Proteasome subunit alpha type | ISS | PubMed:12859888 | |
| H2Q9W6 | Proteasome subunit alpha type | ISS | PubMed:12859888 | |
| O81148 | Proteasome subunit alpha type-4-A | TAS | PubMed:12859888 | |
| P0DKK3 | Proteasome subunit alpha type-4-1 | TAS | PubMed:12859888 | |
| P18053 | Proteasome subunit alpha type-4 | TAS | PubMed:12859888 | |
| P21670 | Proteasome subunit alpha type-4 | ISS | PubMed:12859888 | |
| P23638 | Proteasome subunit alpha type-3 | TAS | PubMed:12859888 | |
| P25789 | Proteasome subunit alpha type-4 | ISS | PubMed:12859888 | |
| P34119 | Proteasome subunit alpha type-4 | TAS | PubMed:12859888 | |
| Q09682 | Probable proteasome subunit alpha type-3 | TAS | PubMed:12859888 | |
| Q3ZCK9 | Proteasome subunit alpha type-4 | ISS | PubMed:12859888 | |
| Q57X58 | Proteasome subunit alpha type | ISS | PubMed:12859888 | |
| Q5VRG3 | Proteasome subunit alpha type-4-2 | TAS | PubMed:12859888 | |
| Q7PPI7 | Proteasome subunit alpha type | TAS | PubMed:12859888 | |
| Q7ZV77 | Proteasome subunit alpha type | ISS | PubMed:12859888 | |
| Q9R1P0 | Proteasome subunit alpha type-4 | ISS | PubMed:12859888 | |
| Q9VA12 | Proteasome subunit alpha type-4-like | TAS | PubMed:12859888 | |
| PTHR11599:SF132 | O24616 | Proteasome subunit alpha type-7-B | ISS | PubMed:12859888 |
| PTHR11599:SF14 | A8WS54 | Proteasome subunit alpha type | ISS | PubMed:12859888 |
| F6QW93 | Proteasome subunit alpha type | ISS | PubMed:12859888 | |
| F6UT72 | Proteasome subunit alpha type-5 | ISS | PubMed:12859888 | |
| I0FTI7 | Proteasome subunit alpha type | ISS | PubMed:12859888 | |
| P28066 | Proteasome subunit alpha type-5 | TAS | PubMed:12859888 | |
| P32379 | Proteasome subunit alpha type-5 | TAS | PubMed:12859888 | |
| P34064 | Proteasome subunit alpha type-5 | ISS | PubMed:12859888 | |
| Q38CL5 | Proteasome subunit alpha type | TAS | PubMed:12859888 | |
| Q4QC00 | Proteasome subunit alpha type | TAS | PubMed:12859888 | |
| Q5E987 | Proteasome subunit alpha type-5 | ISS | PubMed:12859888 | |
| Q6TGV6 | Proteasome subunit alpha type | ISS | PubMed:12859888 | |
| Q7PPM9 | Proteasome subunit alpha type | TAS | PubMed:12859888 | |
| Q94561 | Proteasome subunit alpha type-5 | TAS | PubMed:12859888 | |
| Q95008 | Proteasome subunit alpha type-5 | TAS | PubMed:12859888 | |
| Q95083 | Proteasome subunit alpha type-5 | TAS | PubMed:12859888 | |
| Q9LSU1 | Proteasome subunit alpha type-5 | ISS | PubMed:12859888 | |
| Q9UT97 | Probable proteasome subunit alpha type-5 | TAS | PubMed:12859888 | |
| Q9Z2U1 | Proteasome subunit alpha type-5 | TAS | PubMed:12859888 | |
| PTHR11599:SF144 | A0A8I3RZP6 | Proteasome subunit alpha type | ISS | PubMed:12859888 |
| E1BD83 | Proteasome subunit alpha type | ISS | PubMed:12859888 | |
| H2QED5 | Proteasome subunit alpha type | ISS | PubMed:12859888 | |
| Q6P0I2 | Proteasome subunit alpha type | ISS | PubMed:12859888 | |
| Q8TAA3 | Proteasome subunit alpha-type 8 | ISS | PubMed:12859888 | |
| Q9CWH6 | Proteasome subunit alpha type-8 | ISS | PubMed:12859888 | |
| PTHR11599:SF147 | O81149 | Proteasome subunit alpha type-5-A | ISS | PubMed:12859888 |
| PTHR11599:SF15 | A8XFM4 | Proteasome subunit alpha type | ISS | PubMed:12859888 |
| F0ZNQ2 | Proteasome subunit alpha type (Fragment) | ISS | PubMed:12859888 | |
| P22769 | Proteasome subunit alpha type-7-1 | ISS | PubMed:12859888 | |
| P34120 | Proteasome subunit alpha type-7 | TAS | PubMed:12859888 | |
| P40303 | Proteasome subunit alpha type-4 | TAS | PubMed:12859888 | |
| Q0J006 | Proteasome subunit alpha type-7-B | ISS | PubMed:12859888 | |
| Q10329 | Probable proteasome subunit alpha type-4 | TAS | PubMed:12859888 | |
| Q24178 | Proteasome subunit alpha type-7-1A | TAS | PubMed:12859888 | |
| Q27575 | Proteasome subunit alpha type-7-1B | TAS | PubMed:12859888 | |
| Q384W9 | Proteasome subunit alpha type | TAS | PubMed:12859888 | |
| Q7Q797 | Proteasome subunit alpha type | TAS | PubMed:12859888 | |
| Q95005 | Proteasome subunit alpha type-7 | TAS | PubMed:12859888 | |
| PTHR11599:SF16 | A0A1D5QZ56 | Proteasome subunit alpha type | ISS | PubMed:12859888 |
| A8X8G7 | Proteasome subunit alpha type | ISS | PubMed:12859888 | |
| H2R5C6 | Proteasome subunit alpha type | ISS | PubMed:12859888 | |
| O23708 | Proteasome subunit alpha type-2-A | TAS | PubMed:12859888 | |
| O94579 | Probable proteasome subunit alpha type-2 | TAS | PubMed:12859888 | |
| P23639 | Proteasome subunit alpha type-2 | TAS | PubMed:12859888 | |
| P25787 | Proteasome subunit alpha type-2 | ISS | PubMed:12859888 | |
| P40301 | Proteasome subunit alpha type-2 | TAS | PubMed:12859888 | |
| P49722 | Proteasome subunit alpha type-2 | ISS | PubMed:12859888 | |
| Q27488 | Proteasome subunit alpha type-2 | TAS | PubMed:12859888 | |
| Q38CK9 | Proteasome subunit alpha type | TAS | PubMed:12859888 | |
| Q3T0Y5 | Proteasome subunit alpha type-2 | ISS | PubMed:12859888 | |
| Q4QC13 | Proteasome subunit alpha type | TAS | PubMed:12859888 | |
| Q4VBR8 | Proteasome subunit alpha type | ISS | PubMed:12859888 | |
| Q6H852 | Proteasome subunit alpha type | TAS | PubMed:12859888 | |
| Q8L4A7 | Proteasome subunit alpha type-2-B | TAS | PubMed:12859888 | |
| Q8T0Y8 | Proteasome subunit alpha type | TAS | PubMed:12859888 | |
| Q8X077 | Probable proteasome subunit alpha type-2 | TAS | PubMed:12859888 | |
| PTHR11599:SF162 | P34066 | Proteasome subunit alpha type-1-A | TAS | PubMed:12859888 |
| PTHR11599:SF174 | Q801W1 | Proteasome subunit beta | TAS | PubMed:12859888 |
| PTHR11599:SF185 | P49720 | Proteasome subunit beta type-3 | ISS | PubMed:12859888 |
| PTHR11599:SF216 | O81153 | Proteasome subunit beta type-3-B | TAS | PubMed:12859888 |
| PTHR11599:SF219 | O23710 | Proteasome subunit beta type-7-A | TAS | PubMed:12859888 |
| Q7DLS1 | Proteasome subunit beta type-7-B | TAS | PubMed:12859888 | |
| PTHR11599:SF221 | Q10KF0 | Proteasome subunit alpha type-2 | ISS | PubMed:12859888 |
| PTHR11599:SF40 | F6WS89 | Proteasome subunit alpha type | ISS | PubMed:12859888 |
| H2QKQ2 | Proteasome subunit alpha type | ISS | PubMed:12859888 | |
| O14818 | Proteasome subunit alpha type-7 | ISS | PubMed:12859888 | |
| P48004 | Proteasome subunit alpha type-7 | TAS | PubMed:12859888 | |
| Q3ZBG0 | Proteasome subunit alpha type-7 | ISS | PubMed:12859888 | |
| Q9Z2U0 | Proteasome subunit alpha type-7 | ISS | PubMed:12859888 | |
| PTHR11599:SF41 | H2R3I7 | Proteasome subunit beta | ISS | PubMed:12859888 |
| O35955 | Proteasome subunit beta type-10 | TAS | PubMed:12859888 | |
| P40306 | Proteasome subunit beta type-10 | TAS | PubMed:12859888 | |
| Q4KM35 | Proteasome subunit beta type-10 | ISS | PubMed:12859888 | |
| PTHR11599:SF42 | A0A8I3N5F1 | Proteasome subunit beta | ISS | PubMed:12859888 |
| A0A8M9PQK9 | Proteasome subunit beta | TAS | PubMed:12859888 | |
| F1MBI1 | Proteasome subunit beta | ISS | PubMed:12859888 | |
| F6WNU0 | Proteasome subunit beta | ISS | PubMed:12859888 | |
| H2QXV4 | Proteasome subunit beta | ISS | PubMed:12859888 | |
| P70195 | Proteasome subunit beta type-7 | ISS | PubMed:12859888 | |
| Q99436 | Proteasome subunit beta type-7 | ISS | PubMed:12859888 | |
| Q9JHW0 | Proteasome subunit beta type-7 | ISS | PubMed:12859888 | |
| PTHR11599:SF44 | H2XVD5 | Proteasome subunit beta | TAS | PubMed:12859888 |
| O62102 | Proteasome subunit beta | TAS | PubMed:12859888 | |
| P25043 | Proteasome subunit beta type-2 | TAS | PubMed:12859888 | |
| Q09841 | Probable proteasome subunit beta type-2 | TAS | PubMed:12859888 | |
| Q38DP7 | Proteasome subunit beta | ISS | PubMed:12859888 | |
| Q7Q306 | Proteasome subunit beta | TAS | PubMed:12859888 | |
| Q9LST8 | Proteasome subunit beta | TAS | PubMed:12859888 | |
| Q9VUJ1 | Proteasome subunit beta | TAS | PubMed:12859888 | |
| Q9W470 | Proteasome subunit beta | TAS | PubMed:12859888 | |
| PTHR11599:SF5 | D6XEX9 | Proteasome subunit beta | ISS | PubMed:12859888 |
| Q7DLR9 | Proteasome subunit beta type-4 | TAS | PubMed:12859888 | |
| Q7K6A9 | Proteasome subunit beta | ISS | PubMed:12859888 | |
| Q7Q320 | Proteasome subunit beta | TAS | PubMed:12859888 | |
| Q9USQ9 | Probable proteasome subunit beta type-7 | TAS | PubMed:12859888 | |
| Q9VNA5 | Proteasome subunit beta type-4 | TAS | PubMed:12859888 | |
| PTHR11599:SF62 | A0A8I3RXV3 | Proteasome subunit beta | ISS | PubMed:12859888 |
| A8WUP0 | Proteasome subunit beta | ISS | PubMed:12859888 | |
| D3Z8J0 | Proteasome subunit beta type-3 | TAS | PubMed:12859888 | |
| F6S2Q4 | Proteasome subunit beta | ISS | PubMed:12859888 | |
| P25451 | Proteasome subunit beta type-3 | TAS | PubMed:12859888 | |
| P33672 | Proteasome subunit beta type-3 | ISS | PubMed:12859888 | |
| P40112 | Proteasome subunit beta type-3 | ISS | PubMed:12859888 | |
| Q23237 | Proteasome subunit beta type-3 | TAS | PubMed:12859888 | |
| Q384T8 | Proteasome subunit beta | TAS | PubMed:12859888 | |
| Q6H800 | Proteasome subunit beta | TAS | PubMed:12859888 | |
| Q7PY13 | Proteasome subunit beta | TAS | PubMed:12859888 | |
| Q7ZUJ8 | Proteasome subunit beta | ISS | PubMed:12859888 | |
| Q9R1P1 | Proteasome subunit beta type-3 | ISS | PubMed:12859888 | |
| Q9R1P1 | Proteasome subunit beta type-3 | TAS | PubMed:12859888 | |
| Q9XYN7 | Proteasome subunit beta type-3 | TAS | PubMed:12859888 | |
| Q9Y7T8 | Probable proteasome subunit beta type-3 | TAS | PubMed:12859888 | |
| PTHR32194:SF2 | F7F3A6 | Proteasome subunit beta | ISS | PubMed:12859888 |
| G5E589 | Proteasome subunit beta | ISS | PubMed:12859888 | |
| G7MR84 | Proteasome subunit beta | ISS | PubMed:12859888 | |
| H2QU28 | Proteasome subunit beta | ISS | PubMed:12859888 | |
| O09061 | Proteasome subunit beta type-1 | TAS | PubMed:12859888 | |
| P18421 | Proteasome subunit beta type-1 | ISS | PubMed:12859888 | |
| P20618 | Proteasome subunit beta type-1 | ISS | PubMed:12859888 | |
| Q6DRF3 | Proteasome subunit beta type-1 | ISS | PubMed:12859888 |
