Pathway Component Details
| Name: | Complex I |
| Definition: | Mitochondrial complex I is inhibited by MPP+, a metabolite of MPTP, a drug that has been shown to cause parkinson-like symptoms in humans and animal models. Inhibition of the mitochondrial complex leads to an increase in reactive oxygen species and H2O2 |
| Category ID: | P01237 |
| Synonyms: | |
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| Downstream: | |
| Number Families/Subfamilies: | 3 |
| Number of Associated Sequences: | 20 |
| GO Molecular Function: |
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| GO Biological Process: |
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| GO Cellular Component: |
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| PANTHER protein class: |
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| References: |
Sequence Association
| Panther Subfamily | Associated Sequence | Definition | Confidence Code | Evidence |
| PTHR10371:SF3 | A8XCT2 | Protein CBG11518 | ISS | PubMed:3100899 |
| F2Z6C0 | YALI0D00737p | TAS | PubMed:3100899 | |
| H2RBN7 | NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial | ISS | PubMed:3100899 | |
| P04394 | NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial | ISS | PubMed:3100899 | |
| P0AFD1 | NADH-quinone oxidoreductase subunit E | ISS | PubMed:3100899 | |
| P19234 | NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial | ISS | PubMed:3100899 | |
| P19404 | NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial | ISS | PubMed:3100899 | |
| P40915 | NADH-ubiquinone oxidoreductase 24 kDa subunit, mitochondrial | TAS | PubMed:3100899 | |
| P9WIV5 | NADH-quinone oxidoreductase subunit E | ISS | ||
| Q0MQI9 | NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial | ISS | PubMed:3100899 | |
| Q20719 | Probable NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial | TAS | PubMed:3100899 | |
| Q7QK64 | AGAP002170-PA | TAS | PubMed:3100899 | |
| Q9D6J6 | NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial | ISS | PubMed:3100899 | |
| Q9I0J8 | NADH-quinone oxidoreductase subunit E | TAS | PubMed:3100899 | |
| Q9RU91 | NADH dehydrogenase I, E subunit | TAS | PubMed:3100899 | |
| Q9VVF0 | AT21479p | TAS | PubMed:3100899 | |
| Q9VX36 | NADH dehydrogenase (Ubiquinone) 24 kDa subunit, isoform A | TAS | PubMed:3100899 | |
| Q9XAQ8 | NuoE, NADH dehydrogenase subunit | ISS | ||
| PTHR43342:SF1 | O52681 | Bifurcating [FeFe] hydrogenase gamma subunit | TAS | |
| PTHR43342:SF2 | Q9WXM7 | NADP-reducing hydrogenase, subunit A | TAS |
