Pathway Component Details
| Name: | Son of sevenless (SOS) |
| Definition: | Son of Sevenless (SOS) is a guanine nucleotide exchange factor for the small GTPase, Ras, which it activates by promoting the exchange of GDP for GTP in its nucleotide binding site. This allows Ras to interact with its effector proteins, propagating signals to the nucleus. |
| Category ID: | P01307 |
| Synonyms: | |
| Upstream: | |
| Downstream: | |
| Number Families/Subfamilies: | 2 |
| Number of Associated Sequences: | 16 |
| GO Molecular Function: |
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| GO Biological Process: |
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| GO Cellular Component: |
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| PANTHER protein class: |
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| References: |
Sequence Association
| Panther Subfamily | Associated Sequence | Definition | Confidence Code | Evidence |
| PTHR23113:SF150 | A0A1D5QE14 | SOS Ras_Rho guanine nucleotide exchange factor 2 | ISS | PubMed:1631150 |
| A0A1D5QE14 | SOS Ras_Rho guanine nucleotide exchange factor 2 | ISS | 476780 | |
| A0A1D5QE14 | SOS Ras_Rho guanine nucleotide exchange factor 2 | ISS | PubMed:8188688 | |
| A0A1D5QE14 | SOS Ras_Rho guanine nucleotide exchange factor 2 | ISS | PubMed:8479536 | |
| A0A1D5QE14 | SOS Ras_Rho guanine nucleotide exchange factor 2 | ISS | PubMed:8493579 | |
| A0A1D5QE14 | SOS Ras_Rho guanine nucleotide exchange factor 2 | ISS | PubMed:8621483 | |
| A0A1D5QE14 | SOS Ras_Rho guanine nucleotide exchange factor 2 | ISS | PubMed:92335328 | |
| A0A1D5QE14 | SOS Ras_Rho guanine nucleotide exchange factor 2 | ISS | PubMed:93262494 | |
| A0A1D5QE14 | SOS Ras_Rho guanine nucleotide exchange factor 2 | ISS | PubMed:9744561 | |
| A0A8I3MQH2 | SOS Ras_Rho guanine nucleotide exchange factor 2 | ISS | PubMed:1631150 | |
| A0A8I3MQH2 | SOS Ras_Rho guanine nucleotide exchange factor 2 | ISS | 476780 | |
| A0A8I3MQH2 | SOS Ras_Rho guanine nucleotide exchange factor 2 | ISS | PubMed:8188688 | |
| A0A8I3MQH2 | SOS Ras_Rho guanine nucleotide exchange factor 2 | ISS | PubMed:8479536 | |
| A0A8I3MQH2 | SOS Ras_Rho guanine nucleotide exchange factor 2 | ISS | PubMed:8493579 | |
| A0A8I3MQH2 | SOS Ras_Rho guanine nucleotide exchange factor 2 | ISS | PubMed:8621483 | |
| A0A8I3MQH2 | SOS Ras_Rho guanine nucleotide exchange factor 2 | ISS | PubMed:92335328 | |
| A0A8I3MQH2 | SOS Ras_Rho guanine nucleotide exchange factor 2 | ISS | PubMed:93262494 | |
| A0A8I3MQH2 | SOS Ras_Rho guanine nucleotide exchange factor 2 | ISS | PubMed:9744561 | |
| F1MAI3 | SOS Ras_Rho guanine nucleotide exchange factor 2 | ISS | PubMed:1631150 | |
| F1MAI3 | SOS Ras_Rho guanine nucleotide exchange factor 2 | ISS | 476780 | |
| F1MAI3 | SOS Ras_Rho guanine nucleotide exchange factor 2 | ISS | PubMed:8188688 | |
| F1MAI3 | SOS Ras_Rho guanine nucleotide exchange factor 2 | ISS | PubMed:8479536 | |
| F1MAI3 | SOS Ras_Rho guanine nucleotide exchange factor 2 | ISS | PubMed:8493579 | |
| F1MAI3 | SOS Ras_Rho guanine nucleotide exchange factor 2 | ISS | PubMed:8621483 | |
| F1MAI3 | SOS Ras_Rho guanine nucleotide exchange factor 2 | ISS | PubMed:92335328 | |
| F1MAI3 | SOS Ras_Rho guanine nucleotide exchange factor 2 | ISS | PubMed:93262494 | |
| F1MAI3 | SOS Ras_Rho guanine nucleotide exchange factor 2 | ISS | PubMed:9744561 | |
| F6URW3 | SOS Ras_Rho guanine nucleotide exchange factor 2 | ISS | 476780 | |
| F6URW3 | SOS Ras_Rho guanine nucleotide exchange factor 2 | ISS | PubMed:8188688 | |
| F6URW3 | SOS Ras_Rho guanine nucleotide exchange factor 2 | ISS | PubMed:8479536 | |
| F6URW3 | SOS Ras_Rho guanine nucleotide exchange factor 2 | ISS | PubMed:8493579 | |
| F6URW3 | SOS Ras_Rho guanine nucleotide exchange factor 2 | ISS | PubMed:8621483 | |
| F6URW3 | SOS Ras_Rho guanine nucleotide exchange factor 2 | ISS | PubMed:93262494 | |
| F6URW3 | SOS Ras_Rho guanine nucleotide exchange factor 2 | ISS | PubMed:9744561 | |
| F6YCI3 | SOS Ras_Rho guanine nucleotide exchange factor 2 | ISS | 476780 | |
| F6YCI3 | SOS Ras_Rho guanine nucleotide exchange factor 2 | ISS | PubMed:8188688 | |
| F6YCI3 | SOS Ras_Rho guanine nucleotide exchange factor 2 | ISS | PubMed:8479536 | |
| F6YCI3 | SOS Ras_Rho guanine nucleotide exchange factor 2 | ISS | PubMed:8493579 | |
| F6YCI3 | SOS Ras_Rho guanine nucleotide exchange factor 2 | ISS | PubMed:8621483 | |
| F6YCI3 | SOS Ras_Rho guanine nucleotide exchange factor 2 | ISS | PubMed:93262494 | |
| F6YCI3 | SOS Ras_Rho guanine nucleotide exchange factor 2 | ISS | PubMed:9744561 | |
| K7CZM1 | SOS Ras_Rho guanine nucleotide exchange factor 2 | ISS | PubMed:1631150 | |
| K7CZM1 | SOS Ras_Rho guanine nucleotide exchange factor 2 | ISS | 476780 | |
| K7CZM1 | SOS Ras_Rho guanine nucleotide exchange factor 2 | ISS | PubMed:8188688 | |
| K7CZM1 | SOS Ras_Rho guanine nucleotide exchange factor 2 | ISS | PubMed:8479536 | |
| K7CZM1 | SOS Ras_Rho guanine nucleotide exchange factor 2 | ISS | PubMed:8493579 | |
| K7CZM1 | SOS Ras_Rho guanine nucleotide exchange factor 2 | ISS | PubMed:8621483 | |
| K7CZM1 | SOS Ras_Rho guanine nucleotide exchange factor 2 | ISS | PubMed:92335328 | |
| K7CZM1 | SOS Ras_Rho guanine nucleotide exchange factor 2 | ISS | PubMed:93262494 | |
| K7CZM1 | SOS Ras_Rho guanine nucleotide exchange factor 2 | ISS | PubMed:9744561 | |
| Q02384 | Son of sevenless homolog 2 | IPI | PubMed:1631150 | |
| Q02384 | Son of sevenless homolog 2 | IPI | 476780 | |
| Q02384 | Son of sevenless homolog 2 | IPI | PubMed:8188688 | |
| Q02384 | Son of sevenless homolog 2 | IPI | PubMed:8479536 | |
| Q02384 | Son of sevenless homolog 2 | IPI | PubMed:8493579 | |
| Q02384 | Son of sevenless homolog 2 | IPI | PubMed:8621483 | |
| Q02384 | Son of sevenless homolog 2 | IPI | PubMed:92335328 | |
| Q02384 | Son of sevenless homolog 2 | IPI | PubMed:9744561 | |
| Q07890 | Son of sevenless homolog 2 | IPI | 476780 | |
| Q07890 | Son of sevenless homolog 2 | IPI | PubMed:8188688 | |
| Q07890 | Son of sevenless homolog 2 | IPI | PubMed:8479536 | |
| Q07890 | Son of sevenless homolog 2 | IPI | PubMed:8493579 | |
| Q07890 | Son of sevenless homolog 2 | IPI | PubMed:8621483 | |
| Q07890 | Son of sevenless homolog 2 | IPI | PubMed:93262494 | |
| Q07890 | Son of sevenless homolog 2 | IPI | PubMed:9744561 | |
| PTHR23113:SF168 | A0A8I3S3D9 | SOS Ras_Rac guanine nucleotide exchange factor 1 | ISS | 476780 |
| A0A8I3S3D9 | SOS Ras_Rac guanine nucleotide exchange factor 1 | ISS | PubMed:7478553 | |
| A0A8I3S3D9 | SOS Ras_Rac guanine nucleotide exchange factor 1 | ISS | PubMed:8041791 | |
| A0A8I3S3D9 | SOS Ras_Rac guanine nucleotide exchange factor 1 | ISS | PubMed:8188688 | |
| A0A8I3S3D9 | SOS Ras_Rac guanine nucleotide exchange factor 1 | ISS | PubMed:8479536 | |
| A0A8I3S3D9 | SOS Ras_Rac guanine nucleotide exchange factor 1 | ISS | PubMed:8621483 | |
| A0A8I3S3D9 | SOS Ras_Rac guanine nucleotide exchange factor 1 | ISS | PubMed:9217262 | |
| A0A8I3S3D9 | SOS Ras_Rac guanine nucleotide exchange factor 1 | ISS | PubMed:92335328 | |
| A0A8I3S3D9 | SOS Ras_Rac guanine nucleotide exchange factor 1 | ISS | PubMed:93262494 | |
| A0A8I3S3D9 | SOS Ras_Rac guanine nucleotide exchange factor 1 | ISS | PubMed:9744561 | |
| A0A8I3S3D9 | SOS Ras_Rac guanine nucleotide exchange factor 1 | ISS | PubMed:98043737 | |
| D4A3T0 | SOS Ras_Rac guanine nucleotide exchange factor 1 | ISS | 476780 | |
| D4A3T0 | SOS Ras_Rac guanine nucleotide exchange factor 1 | ISS | PubMed:7478553 | |
| D4A3T0 | SOS Ras_Rac guanine nucleotide exchange factor 1 | ISS | PubMed:8041791 | |
| D4A3T0 | SOS Ras_Rac guanine nucleotide exchange factor 1 | ISS | PubMed:8188688 | |
| D4A3T0 | SOS Ras_Rac guanine nucleotide exchange factor 1 | ISS | PubMed:8479536 | |
| D4A3T0 | SOS Ras_Rac guanine nucleotide exchange factor 1 | ISS | PubMed:8621483 | |
| D4A3T0 | SOS Ras_Rac guanine nucleotide exchange factor 1 | ISS | PubMed:9217262 | |
| D4A3T0 | SOS Ras_Rac guanine nucleotide exchange factor 1 | ISS | PubMed:92335328 | |
| D4A3T0 | SOS Ras_Rac guanine nucleotide exchange factor 1 | ISS | PubMed:93262494 | |
| D4A3T0 | SOS Ras_Rac guanine nucleotide exchange factor 1 | ISS | PubMed:9744561 | |
| D4A3T0 | SOS Ras_Rac guanine nucleotide exchange factor 1 | ISS | PubMed:98043737 | |
| F1N7C3 | SOS Ras_Rac guanine nucleotide exchange factor 1 | ISS | 476780 | |
| F1N7C3 | SOS Ras_Rac guanine nucleotide exchange factor 1 | ISS | PubMed:7478553 | |
| F1N7C3 | SOS Ras_Rac guanine nucleotide exchange factor 1 | ISS | PubMed:8041791 | |
| F1N7C3 | SOS Ras_Rac guanine nucleotide exchange factor 1 | ISS | PubMed:8188688 | |
| F1N7C3 | SOS Ras_Rac guanine nucleotide exchange factor 1 | ISS | PubMed:8479536 | |
| F1N7C3 | SOS Ras_Rac guanine nucleotide exchange factor 1 | ISS | PubMed:8621483 | |
| F1N7C3 | SOS Ras_Rac guanine nucleotide exchange factor 1 | ISS | PubMed:9217262 | |
| F1N7C3 | SOS Ras_Rac guanine nucleotide exchange factor 1 | ISS | PubMed:92335328 | |
| F1N7C3 | SOS Ras_Rac guanine nucleotide exchange factor 1 | ISS | PubMed:93262494 | |
| F1N7C3 | SOS Ras_Rac guanine nucleotide exchange factor 1 | ISS | PubMed:9744561 | |
| F1N7C3 | SOS Ras_Rac guanine nucleotide exchange factor 1 | ISS | PubMed:98043737 | |
| F6QUW1 | SOS Ras_Rac guanine nucleotide exchange factor 1 | ISS | 476780 | |
| F6QUW1 | SOS Ras_Rac guanine nucleotide exchange factor 1 | ISS | PubMed:7478553 | |
| F6QUW1 | SOS Ras_Rac guanine nucleotide exchange factor 1 | ISS | PubMed:8041791 | |
| F6QUW1 | SOS Ras_Rac guanine nucleotide exchange factor 1 | ISS | PubMed:8188688 | |
| F6QUW1 | SOS Ras_Rac guanine nucleotide exchange factor 1 | ISS | PubMed:8479536 | |
| F6QUW1 | SOS Ras_Rac guanine nucleotide exchange factor 1 | ISS | PubMed:8621483 | |
| F6QUW1 | SOS Ras_Rac guanine nucleotide exchange factor 1 | ISS | PubMed:9217262 | |
| F6QUW1 | SOS Ras_Rac guanine nucleotide exchange factor 1 | ISS | PubMed:92335328 | |
| F6QUW1 | SOS Ras_Rac guanine nucleotide exchange factor 1 | ISS | PubMed:93262494 | |
| F6QUW1 | SOS Ras_Rac guanine nucleotide exchange factor 1 | ISS | PubMed:9744561 | |
| F6QUW1 | SOS Ras_Rac guanine nucleotide exchange factor 1 | ISS | PubMed:98043737 | |
| F7BWW9 | SOS Ras_Rac guanine nucleotide exchange factor 1 | ISS | 476780 | |
| F7BWW9 | SOS Ras_Rac guanine nucleotide exchange factor 1 | ISS | PubMed:7478553 | |
| F7BWW9 | SOS Ras_Rac guanine nucleotide exchange factor 1 | ISS | PubMed:8041791 | |
| F7BWW9 | SOS Ras_Rac guanine nucleotide exchange factor 1 | ISS | PubMed:8188688 | |
| F7BWW9 | SOS Ras_Rac guanine nucleotide exchange factor 1 | ISS | PubMed:8479536 | |
| F7BWW9 | SOS Ras_Rac guanine nucleotide exchange factor 1 | ISS | PubMed:8621483 | |
| F7BWW9 | SOS Ras_Rac guanine nucleotide exchange factor 1 | ISS | PubMed:9217262 | |
| F7BWW9 | SOS Ras_Rac guanine nucleotide exchange factor 1 | ISS | PubMed:92335328 | |
| F7BWW9 | SOS Ras_Rac guanine nucleotide exchange factor 1 | ISS | PubMed:93262494 | |
| F7BWW9 | SOS Ras_Rac guanine nucleotide exchange factor 1 | ISS | PubMed:9744561 | |
| F7BWW9 | SOS Ras_Rac guanine nucleotide exchange factor 1 | ISS | PubMed:98043737 | |
| H2R8U9 | SOS Ras_Rac guanine nucleotide exchange factor 1 | ISS | 476780 | |
| H2R8U9 | SOS Ras_Rac guanine nucleotide exchange factor 1 | ISS | PubMed:7478553 | |
| H2R8U9 | SOS Ras_Rac guanine nucleotide exchange factor 1 | ISS | PubMed:8041791 | |
| H2R8U9 | SOS Ras_Rac guanine nucleotide exchange factor 1 | ISS | PubMed:8188688 | |
| H2R8U9 | SOS Ras_Rac guanine nucleotide exchange factor 1 | ISS | PubMed:8479536 | |
| H2R8U9 | SOS Ras_Rac guanine nucleotide exchange factor 1 | ISS | PubMed:8621483 | |
| H2R8U9 | SOS Ras_Rac guanine nucleotide exchange factor 1 | ISS | PubMed:9217262 | |
| H2R8U9 | SOS Ras_Rac guanine nucleotide exchange factor 1 | ISS | PubMed:92335328 | |
| H2R8U9 | SOS Ras_Rac guanine nucleotide exchange factor 1 | ISS | PubMed:93262494 | |
| H2R8U9 | SOS Ras_Rac guanine nucleotide exchange factor 1 | ISS | PubMed:9744561 | |
| H2R8U9 | SOS Ras_Rac guanine nucleotide exchange factor 1 | ISS | PubMed:98043737 | |
| Q07889 | Son of sevenless homolog 1 | IPI | 476780 | |
| Q07889 | Son of sevenless homolog 1 | IPI | PubMed:7478553 | |
| Q07889 | Son of sevenless homolog 1 | IPI | PubMed:8041791 | |
| Q07889 | Son of sevenless homolog 1 | IPI | PubMed:8188688 | |
| Q07889 | Son of sevenless homolog 1 | IPI | PubMed:8479536 | |
| Q07889 | Son of sevenless homolog 1 | IPI | PubMed:8621483 | |
| Q07889 | Son of sevenless homolog 1 | IPI | PubMed:9217262 | |
| Q07889 | Son of sevenless homolog 1 | IPI | PubMed:93262494 | |
| Q07889 | Son of sevenless homolog 1 | IPI | PubMed:9744561 | |
| Q07889 | Son of sevenless homolog 1 | IPI | PubMed:98043737 | |
| Q62245 | Son of sevenless homolog 1 | IPI | 476780 | |
| Q62245 | Son of sevenless homolog 1 | IPI | PubMed:7478553 | |
| Q62245 | Son of sevenless homolog 1 | IPI | PubMed:8041791 | |
| Q62245 | Son of sevenless homolog 1 | IPI | PubMed:8188688 | |
| Q62245 | Son of sevenless homolog 1 | IPI | PubMed:8479536 | |
| Q62245 | Son of sevenless homolog 1 | IPI | PubMed:8621483 | |
| Q62245 | Son of sevenless homolog 1 | IPI | PubMed:9217262 | |
| Q62245 | Son of sevenless homolog 1 | IPI | PubMed:92335328 | |
| Q62245 | Son of sevenless homolog 1 | IPI | PubMed:93262494 | |
| Q62245 | Son of sevenless homolog 1 | IPI | PubMed:9744561 | |
| Q62245 | Son of sevenless homolog 1 | IPI | PubMed:98043737 |
