Pathway Component Details
| Name: | nck |
| Definition: | Nck is an adapter protein that translocates from the cytoplasm to the plasma membrane by binding to phosphorylated SLP-76 via its SH2 domain. Membrane-localized Nck can then recruit WASP to the cell surface and thereby regulate actin dynamics and cell polarization toward the APC. |
| Category ID: | P01314 |
| Synonyms: | |
| Upstream: | |
| Downstream: | |
| Number Families/Subfamilies: | 2 |
| Number of Associated Sequences: | 13 |
| GO Molecular Function: |
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| GO Biological Process: |
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| GO Cellular Component: |
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| PANTHER protein class: |
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| References: |
Sequence Association
| Panther Subfamily | Associated Sequence | Definition | Confidence Code | Evidence |
| PTHR19969:SF12 | A0A5F8AJZ6 | Cytoplasmic protein | ISS | PubMed:12874226 |
| D4A3M8 | Cytoplasmic protein | ISS | PubMed:12874226 | |
| F1P4Q4 | Cytoplasmic protein | ISS | PubMed:12874226 | |
| F7ALW1 | Cytoplasmic protein | ISS | PubMed:12874226 | |
| H2QIH7 | Cytoplasmic protein | ISS | PubMed:12874226 | |
| O43639 | Cytoplasmic protein NCK2 | IPI | PubMed:12874226 | |
| O55033 | Cytoplasmic protein NCK2 | ISS | PubMed:12874226 | |
| PTHR19969:SF16 | A0A8I3S602 | Cytoplasmic protein | ISS | PubMed:11689432 |
| A0A8I3S602 | Cytoplasmic protein | ISS | PubMed:12874226 | |
| F7GD33 | Cytoplasmic protein | ISS | PubMed:11689432 | |
| F7GD33 | Cytoplasmic protein | ISS | PubMed:12874226 | |
| G2HHN0 | Cytoplasmic protein | ISS | PubMed:11689432 | |
| G2HHN0 | Cytoplasmic protein | ISS | PubMed:12874226 | |
| P16333 | Cytoplasmic protein NCK1 | IPI | PubMed:11689432 | |
| P16333 | Cytoplasmic protein NCK1 | IPI | PubMed:12874226 | |
| Q1LZB2 | Cytoplasmic protein | ISS | PubMed:11689432 | |
| Q1LZB2 | Cytoplasmic protein | ISS | PubMed:12874226 | |
| Q99M51 | Cytoplasmic protein NCK1 | ISS | PubMed:11689432 | |
| Q99M51 | Cytoplasmic protein NCK1 | ISS | PubMed:12874226 |
