Pathway Component Details
| Name: | p21-activated kinase (PAK) |
| Definition: | Pak is an effector protein for the GTPase Rac. Upon binding to membrane-associated, GTP-bound Rac, Pak phosphorylates a number of downstream proteins that regulate cytoskeletal structure and polarization. |
| Category ID: | P01319 |
| Synonyms: | |
| Upstream: | |
| Downstream: | |
| Number Families/Subfamilies: | 3 |
| Number of Associated Sequences: | 25 |
| GO Molecular Function: |
-
|
| GO Biological Process: |
-
|
| GO Cellular Component: |
-
|
| PANTHER protein class: |
-
|
| References: |
Sequence Association
| Panther Subfamily | Associated Sequence | Definition | Confidence Code | Evidence |
| PTHR48015:SF20 | A0A8I3NMF7 | P21 (RAC1) activated kinase 1 | ISS | PubMed:10508610 |
| A0A8I3NMF7 | P21 (RAC1) activated kinase 1 | ISS | PubMed:11689432 | |
| A0A8I3NMF7 | P21 (RAC1) activated kinase 1 | ISS | PubMed:12912914 | |
| A0A8I3NMF7 | P21 (RAC1) activated kinase 1 | ISS | PubMed:14580336 | |
| A0A8I3NMF7 | P21 (RAC1) activated kinase 1 | ISS | PubMed:15187108 | |
| E1C3P6 | non-specific serine_threonine protein kinase | ISS | PubMed:10508610 | |
| E1C3P6 | non-specific serine_threonine protein kinase | ISS | PubMed:11689432 | |
| E1C3P6 | non-specific serine_threonine protein kinase | ISS | PubMed:12912914 | |
| E1C3P6 | non-specific serine_threonine protein kinase | ISS | PubMed:14580336 | |
| E1C3P6 | non-specific serine_threonine protein kinase | ISS | PubMed:15187108 | |
| H9EM79 | non-specific serine_threonine protein kinase | ISS | PubMed:10508610 | |
| H9EM79 | non-specific serine_threonine protein kinase | ISS | PubMed:11689432 | |
| H9EM79 | non-specific serine_threonine protein kinase | ISS | PubMed:12912914 | |
| H9EM79 | non-specific serine_threonine protein kinase | ISS | PubMed:14580336 | |
| H9EM79 | non-specific serine_threonine protein kinase | ISS | PubMed:15187108 | |
| O88643 | Serine_threonine-protein kinase PAK 1 | IDA | PubMed:10508610 | |
| O88643 | Serine_threonine-protein kinase PAK 1 | IDA | PubMed:11689432 | |
| O88643 | Serine_threonine-protein kinase PAK 1 | IDA | PubMed:12912914 | |
| O88643 | Serine_threonine-protein kinase PAK 1 | IDA | PubMed:14580336 | |
| O88643 | Serine_threonine-protein kinase PAK 1 | IDA | PubMed:15187108 | |
| P35465 | Serine_threonine-protein kinase PAK 1 | ISS | PubMed:10508610 | |
| P35465 | Serine_threonine-protein kinase PAK 1 | ISS | PubMed:11689432 | |
| P35465 | Serine_threonine-protein kinase PAK 1 | ISS | PubMed:12912914 | |
| P35465 | Serine_threonine-protein kinase PAK 1 | ISS | PubMed:15187108 | |
| Q08E52 | Serine_threonine-protein kinase PAK 1 | ISS | PubMed:10508610 | |
| Q08E52 | Serine_threonine-protein kinase PAK 1 | ISS | PubMed:11689432 | |
| Q08E52 | Serine_threonine-protein kinase PAK 1 | ISS | PubMed:12912914 | |
| Q08E52 | Serine_threonine-protein kinase PAK 1 | ISS | PubMed:14580336 | |
| Q08E52 | Serine_threonine-protein kinase PAK 1 | ISS | PubMed:15187108 | |
| Q13153 | Serine_threonine-protein kinase PAK 1 | IDA | PubMed:10508610 | |
| Q13153 | Serine_threonine-protein kinase PAK 1 | IDA | PubMed:11689432 | |
| Q13153 | Serine_threonine-protein kinase PAK 1 | IDA | PubMed:12912914 | |
| Q13153 | Serine_threonine-protein kinase PAK 1 | IDA | PubMed:15187108 | |
| PTHR48015:SF22 | A0A3Q1M0G8 | non-specific serine_threonine protein kinase | ISS | PubMed:15187108 |
| A0A3Q1M0G8 | non-specific serine_threonine protein kinase | ISS | PubMed:8626411 | |
| A0A8I3QD39 | non-specific serine_threonine protein kinase | ISS | PubMed:15187108 | |
| A0A8I3QD39 | non-specific serine_threonine protein kinase | ISS | PubMed:8626411 | |
| A0A8J0QMG0 | non-specific serine_threonine protein kinase | ISS | PubMed:10644687 | |
| A0A8J0QMG0 | non-specific serine_threonine protein kinase | ISS | PubMed:15187108 | |
| E1BS97 | non-specific serine_threonine protein kinase | ISS | PubMed:10644687 | |
| E1BS97 | non-specific serine_threonine protein kinase | ISS | PubMed:15187108 | |
| E1BS97 | non-specific serine_threonine protein kinase | ISS | PubMed:8626411 | |
| F7CU42 | Protein kinase domain-containing protein | ISS | PubMed:15187108 | |
| F7CU42 | Protein kinase domain-containing protein | ISS | PubMed:8626411 | |
| F7GWI2 | non-specific serine_threonine protein kinase | ISS | PubMed:15187108 | |
| F7GWI2 | non-specific serine_threonine protein kinase | ISS | PubMed:8626411 | |
| H2QP14 | non-specific serine_threonine protein kinase | ISS | PubMed:15187108 | |
| H2QP14 | non-specific serine_threonine protein kinase | ISS | PubMed:8626411 | |
| Q13177 | Serine_threonine-protein kinase PAK 2 | IDA | PubMed:15187108 | |
| Q13177 | Serine_threonine-protein kinase PAK 2 | IDA | PubMed:8626411 | |
| Q64303 | Serine_threonine-protein kinase PAK 2 | IDA | PubMed:15187108 | |
| Q64303 | Serine_threonine-protein kinase PAK 2 | IDA | PubMed:8626411 | |
| Q8CIN4 | Serine_threonine-protein kinase PAK 2 | ISS | PubMed:15187108 | |
| Q8CIN4 | Serine_threonine-protein kinase PAK 2 | ISS | PubMed:8626411 | |
| PTHR48015:SF30 | A0A3Q1LNA9 | Serine_threonine-protein kinase PAK 3 | ISS | PubMed:11259591 |
| A0A3Q1LNA9 | Serine_threonine-protein kinase PAK 3 | ISS | PubMed:15187108 | |
| A0A3Q1LNA9 | Serine_threonine-protein kinase PAK 3 | ISS | PubMed:7559398 | |
| A0A3Q1LNA9 | Serine_threonine-protein kinase PAK 3 | ISS | PubMed:7559638 | |
| A0A5F8G6K2 | non-specific serine_threonine protein kinase | ISS | PubMed:11259591 | |
| A0A5F8G6K2 | non-specific serine_threonine protein kinase | ISS | PubMed:15187108 | |
| A0A5F8G6K2 | non-specific serine_threonine protein kinase | ISS | PubMed:7559398 | |
| A0A5F8G6K2 | non-specific serine_threonine protein kinase | ISS | PubMed:7559638 | |
| A0A6I8P0H1 | non-specific serine_threonine protein kinase | ISS | PubMed:11259591 | |
| A0A6I8P0H1 | non-specific serine_threonine protein kinase | ISS | PubMed:15187108 | |
| A0A6I8P0H1 | non-specific serine_threonine protein kinase | ISS | PubMed:7559398 | |
| A0A6I8P0H1 | non-specific serine_threonine protein kinase | ISS | PubMed:7559638 | |
| A0A8V0YYX2 | Serine_threonine-protein kinase PAK 3 | ISS | PubMed:11259591 | |
| A0A8V0YYX2 | Serine_threonine-protein kinase PAK 3 | ISS | PubMed:15187108 | |
| A0A8V0YYX2 | Serine_threonine-protein kinase PAK 3 | ISS | PubMed:7559398 | |
| A0A8V0YYX2 | Serine_threonine-protein kinase PAK 3 | ISS | PubMed:7559638 | |
| O75914 | Serine_threonine-protein kinase PAK 3 | IDA | PubMed:11259591 | |
| O75914 | Serine_threonine-protein kinase PAK 3 | IDA | PubMed:15187108 | |
| O75914 | Serine_threonine-protein kinase PAK 3 | IDA | PubMed:7559638 | |
| Q61036 | Serine_threonine-protein kinase PAK 3 | ISS | PubMed:15187108 | |
| Q61036 | Serine_threonine-protein kinase PAK 3 | ISS | PubMed:7559638 | |
| Q62829 | Serine_threonine-protein kinase PAK 3 | IDA | PubMed:15187108 | |
| Q62829 | Serine_threonine-protein kinase PAK 3 | IDA | PubMed:7559638 | |
| Q7YQL4 | Serine_threonine-protein kinase PAK 3 | ISS | PubMed:11259591 | |
| Q7YQL4 | Serine_threonine-protein kinase PAK 3 | ISS | PubMed:15187108 | |
| Q7YQL4 | Serine_threonine-protein kinase PAK 3 | ISS | PubMed:7559398 | |
| Q7YQL4 | Serine_threonine-protein kinase PAK 3 | ISS | PubMed:7559638 |
