Pathway Component Details
| Name: | TPL2 |
| Definition: | Tpl2 gene encodes a serine/threonine protein kinase that can act as a novel mitogen-activated protein (MAP) kinase kinase kinase. Toll-like receptors (TLRs) signaling activate ERK1 and ERK2 MAPKs via the kinase Tpl2. |
| Category ID: | P01364 |
| Synonyms: | |
| Upstream: |
?
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| Downstream: |
mitogen-activated protein kinase kinase 2
(MKK2)
mitogen-activated protein kinase kinase 1 (MKK1) |
| Number Families/Subfamilies: | 1 |
| Number of Associated Sequences: | 7 |
| GO Molecular Function: |
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| GO Biological Process: |
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| GO Cellular Component: |
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| PANTHER protein class: |
-
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| References: |
Sequence Association
| Panther Subfamily | Associated Sequence | Definition | Confidence Code | Evidence |
| PTHR48016:SF31 | A0A8I3N8I4 | Mitogen-activated protein kinase kinase kinase 8 | ISS | PubMed:92019818 |
| A0A8I3N8I4 | Mitogen-activated protein kinase kinase kinase 8 | ISS | PubMed:99133929 | |
| A5PK86 | Mitogen-activated protein kinase kinase kinase 8 | ISS | PubMed:92019818 | |
| A5PK86 | Mitogen-activated protein kinase kinase kinase 8 | ISS | PubMed:99133929 | |
| F6QKJ0 | Mitogen-activated protein kinase kinase kinase 8 | ISS | PubMed:92019818 | |
| H2Q1S6 | Mitogen-activated protein kinase kinase kinase 8 | ISS | PubMed:92019818 | |
| H2Q1S6 | Mitogen-activated protein kinase kinase kinase 8 | ISS | PubMed:99133929 | |
| P41279 | Mitogen-activated protein kinase kinase kinase 8 | IDA | PubMed:92019818 | |
| Q07174 | Mitogen-activated protein kinase kinase kinase 8 | ISS | PubMed:92019818 | |
| Q07174 | Mitogen-activated protein kinase kinase kinase 8 | ISS | PubMed:99133929 | |
| Q63562 | Mitogen-activated protein kinase kinase kinase 8 | IDA | PubMed:99133929 |
