Pathway Component Details
| Name: | tumor necrosis factor (TNF) receptor-associated factor 6 (TRAF6) |
| Definition: | Toll-like receptors (TLRs) sense invading pathogens by recognizing specific microbial patterns (PAMPs) and induce the activation of innate immunity. Upon PAMP recognition, TLRs recruit IL-1R-associated kinase (IRAK) through the adapter MyD88 resulting actiavtion of TRAF6 leading to the translocation of the NF-kB transcription factor and subsequently the production of pro-inflammatory cytokines. |
| Category ID: | P01371 |
| Synonyms: | |
| Upstream: |
A20
IRAK1 |
| Downstream: | |
| Number Families/Subfamilies: | 2 |
| Number of Associated Sequences: | 3 |
| GO Molecular Function: |
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| GO Biological Process: |
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| GO Cellular Component: |
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| PANTHER protein class: |
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| References: |
Sequence Association
| Panther Subfamily | Associated Sequence | Definition | Confidence Code | Evidence |
| PTHR10131:SF131 | H2Q3F3 | TNF receptor-associated factor | ISS | |
| Q9Y4K3 | TNF receptor-associated factor 6 | ISS | ||
| PTHR10131:SF152 | B6CJY5 | TNF receptor-associated factor 6 | ISS |
