Pathway Component Details
| Name: | myeloid differentiation factor 88 (MyD88) |
| Definition: | Toll-like receptors (TLRs) play a role in innate immunity to pathogens by sensing microorganisms through structural motifs called pathogen-associated microbial patterns (PAMPs). Stimulation of TLRs by PAMPs initiates a signaling cascade that involves adaptor proteins such as MyD88 ultimately leading to the activation of the transcription factor NF-kB. MyD88 protein possesses a TIR domain similar to that of TLRs in the C-terminal domain. Upon ligand stimulation, TLRs bind to MyD88 and recruit IRAK then TRAF6. MyD88 is required for TLR signaling since MyD88 -/- mice fail to induce cytokines in response to LPS and CpG DNA. |
| Category ID: | P01377 |
| Synonyms: | |
| Upstream: | |
| Downstream: |
IRAK4
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| Number Families/Subfamilies: | 3 |
| Number of Associated Sequences: | 5 |
| GO Molecular Function: |
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| GO Biological Process: |
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| GO Cellular Component: |
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| PANTHER protein class: |
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| References: |
Sequence Association
| Panther Subfamily | Associated Sequence | Definition | Confidence Code | Evidence |
| PTHR15079:SF11 | H9Z267 | Myeloid differentiation primary response protein MyD88 | ISS | |
| PTHR15079:SF12 | Q99836 | Myeloid differentiation primary response protein MyD88 | ISS | |
| PTHR15079:SF3 | P22366 | Myeloid differentiation primary response protein MyD88 | ISS | |
| Q28DJ2 | Myeloid differentiation primary response protein MyD88 | ISS | ||
| Q6Y1S1 | Myeloid differentiation primary response protein MyD88 | ISS |
