Pathway Component Details
| Name: | Extracellular Signal-Regulated Kinase (Erk) |
| Definition: | Growth factor regulated intracellular kinase. |
| Category ID: | P01407 |
| Synonyms: | |
| Upstream: |
Mitogen-activated protein kinase kinase
(MEK)
|
| Downstream: |
v-Ets Avian Erythroblastosis Virus E26 Oncogene Homolog 1
(Ets)
Cytoplasmic Phospholipase A2 (cPLA2) Hypoxia-Inducible Factor 1 (HIF-1) |
| Number Families/Subfamilies: | 2 |
| Number of Associated Sequences: | 18 |
| GO Molecular Function: |
-
|
| GO Biological Process: |
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| GO Cellular Component: |
-
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| PANTHER protein class: |
-
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| References: |
Sequence Association
| Panther Subfamily | Associated Sequence | Definition | Confidence Code | Evidence |
| PTHR24055:SF393 | A0A1D5QZ91 | Mitogen-activated protein kinase | ISS | PubMed:10514528 |
| A0A1D5QZ91 | Mitogen-activated protein kinase | ISS | PubMed:10851062 | |
| A0A1D5QZ91 | Mitogen-activated protein kinase | ISS | PubMed:11707292 | |
| A0A1D5QZ91 | Mitogen-activated protein kinase | ISS | PubMed:12787066 | |
| A0A1D5QZ91 | Mitogen-activated protein kinase | ISS | PubMed:1533654 | |
| A0A1D5QZ91 | Mitogen-activated protein kinase | ISS | PubMed:92020947 | |
| A0A1D5QZ91 | Mitogen-activated protein kinase | ISS | 9836510 | |
| A0A8I3NHW4 | Protein kinase domain-containing protein | ISS | PubMed:10514528 | |
| A0A8I3NHW4 | Protein kinase domain-containing protein | ISS | PubMed:10851062 | |
| A0A8I3NHW4 | Protein kinase domain-containing protein | ISS | PubMed:11707292 | |
| A0A8I3NHW4 | Protein kinase domain-containing protein | ISS | PubMed:11790551 | |
| A0A8I3NHW4 | Protein kinase domain-containing protein | ISS | PubMed:12787066 | |
| A0A8I3NHW4 | Protein kinase domain-containing protein | ISS | PubMed:1533654 | |
| A0A8I3NHW4 | Protein kinase domain-containing protein | ISS | 20384797 | |
| A0A8I3NHW4 | Protein kinase domain-containing protein | ISS | PubMed:8759724 | |
| A0A8I3NHW4 | Protein kinase domain-containing protein | ISS | 9836510 | |
| E1B8P9 | Mitogen-activated protein kinase | ISS | PubMed:10514528 | |
| E1B8P9 | Mitogen-activated protein kinase | ISS | PubMed:10748187 | |
| E1B8P9 | Mitogen-activated protein kinase | ISS | PubMed:10851062 | |
| E1B8P9 | Mitogen-activated protein kinase | ISS | PubMed:11707292 | |
| E1B8P9 | Mitogen-activated protein kinase | ISS | PubMed:11790551 | |
| E1B8P9 | Mitogen-activated protein kinase | ISS | PubMed:12787066 | |
| E1B8P9 | Mitogen-activated protein kinase | ISS | PubMed:1372523 | |
| E1B8P9 | Mitogen-activated protein kinase | ISS | PubMed:1533654 | |
| E1B8P9 | Mitogen-activated protein kinase | ISS | 20562757 | |
| E1B8P9 | Mitogen-activated protein kinase | ISS | 20843630 | |
| E1B8P9 | Mitogen-activated protein kinase | ISS | OMIM:601795 | |
| E1B8P9 | Mitogen-activated protein kinase | ISS | PubMed:8759724 | |
| E1B8P9 | Mitogen-activated protein kinase | ISS | 9836510 | |
| F7EI48 | Mitogen-activated protein kinase | ISS | PubMed:10514528 | |
| F7EI48 | Mitogen-activated protein kinase | ISS | PubMed:10748187 | |
| F7EI48 | Mitogen-activated protein kinase | ISS | PubMed:10851062 | |
| F7EI48 | Mitogen-activated protein kinase | ISS | PubMed:11707292 | |
| F7EI48 | Mitogen-activated protein kinase | ISS | PubMed:11790551 | |
| F7EI48 | Mitogen-activated protein kinase | ISS | PubMed:12787066 | |
| F7EI48 | Mitogen-activated protein kinase | ISS | PubMed:1372523 | |
| F7EI48 | Mitogen-activated protein kinase | ISS | PubMed:1533654 | |
| F7EI48 | Mitogen-activated protein kinase | ISS | 20562757 | |
| F7EI48 | Mitogen-activated protein kinase | ISS | 20843630 | |
| F7EI48 | Mitogen-activated protein kinase | ISS | OMIM:601795 | |
| F7EI48 | Mitogen-activated protein kinase | ISS | PubMed:8759724 | |
| F7EI48 | Mitogen-activated protein kinase | ISS | 9836510 | |
| H2RA86 | Mitogen-activated protein kinase | ISS | PubMed:10514528 | |
| H2RA86 | Mitogen-activated protein kinase | ISS | PubMed:10748187 | |
| H2RA86 | Mitogen-activated protein kinase | ISS | PubMed:10851062 | |
| H2RA86 | Mitogen-activated protein kinase | ISS | PubMed:11707292 | |
| H2RA86 | Mitogen-activated protein kinase | ISS | PubMed:11790551 | |
| H2RA86 | Mitogen-activated protein kinase | ISS | PubMed:12787066 | |
| H2RA86 | Mitogen-activated protein kinase | ISS | PubMed:1372523 | |
| H2RA86 | Mitogen-activated protein kinase | ISS | PubMed:1533654 | |
| H2RA86 | Mitogen-activated protein kinase | ISS | 20384795 | |
| H2RA86 | Mitogen-activated protein kinase | ISS | 20562757 | |
| H2RA86 | Mitogen-activated protein kinase | ISS | 20843630 | |
| H2RA86 | Mitogen-activated protein kinase | ISS | OMIM:601795 | |
| H2RA86 | Mitogen-activated protein kinase | ISS | PubMed:8759724 | |
| H2RA86 | Mitogen-activated protein kinase | ISS | 9836510 | |
| P21708 | Mitogen-activated protein kinase 3 | ISS | PubMed:10514528 | |
| P21708 | Mitogen-activated protein kinase 3 | ISS | PubMed:10748187 | |
| P21708 | Mitogen-activated protein kinase 3 | ISS | PubMed:10851062 | |
| P21708 | Mitogen-activated protein kinase 3 | ISS | PubMed:11707292 | |
| P21708 | Mitogen-activated protein kinase 3 | ISS | PubMed:11790551 | |
| P21708 | Mitogen-activated protein kinase 3 | ISS | PubMed:12787066 | |
| P21708 | Mitogen-activated protein kinase 3 | ISS | PubMed:1533654 | |
| P21708 | Mitogen-activated protein kinase 3 | ISS | PubMed:20283605 | |
| P21708 | Mitogen-activated protein kinase 3 | ISS | OMIM:601795 | |
| P21708 | Mitogen-activated protein kinase 3 | ISS | PubMed:8759724 | |
| P21708 | Mitogen-activated protein kinase 3 | ISS | 9836510 | |
| P27361 | Mitogen-activated protein kinase 3 | ISS | PubMed:10514528 | |
| P27361 | Mitogen-activated protein kinase 3 | ISS | PubMed:10748187 | |
| P27361 | Mitogen-activated protein kinase 3 | ISS | PubMed:10851062 | |
| P27361 | Mitogen-activated protein kinase 3 | ISS | PubMed:11707292 | |
| P27361 | Mitogen-activated protein kinase 3 | ISS | PubMed:11790551 | |
| P27361 | Mitogen-activated protein kinase 3 | ISS | PubMed:12787066 | |
| P27361 | Mitogen-activated protein kinase 3 | ISS | PubMed:1372523 | |
| P27361 | Mitogen-activated protein kinase 3 | ISS | PubMed:1533654 | |
| P27361 | Mitogen-activated protein kinase 3 | ISS | PubMed:20283605 | |
| P27361 | Mitogen-activated protein kinase 3 | ISS | 20384795 | |
| P27361 | Mitogen-activated protein kinase 3 | ISS | 20562757 | |
| P27361 | Mitogen-activated protein kinase 3 | ISS | 20843630 | |
| P27361 | Mitogen-activated protein kinase 3 | ISS | OMIM:601795 | |
| P27361 | Mitogen-activated protein kinase 3 | ISS | PubMed:8759724 | |
| P27361 | Mitogen-activated protein kinase 3 | ISS | 9836510 | |
| Q63844 | Mitogen-activated protein kinase 3 | ISS | PubMed:10514528 | |
| Q63844 | Mitogen-activated protein kinase 3 | ISS | PubMed:10748187 | |
| Q63844 | Mitogen-activated protein kinase 3 | ISS | PubMed:10851062 | |
| Q63844 | Mitogen-activated protein kinase 3 | ISS | PubMed:11707292 | |
| Q63844 | Mitogen-activated protein kinase 3 | ISS | PubMed:11790551 | |
| Q63844 | Mitogen-activated protein kinase 3 | ISS | PubMed:12787066 | |
| Q63844 | Mitogen-activated protein kinase 3 | ISS | PubMed:1372523 | |
| Q63844 | Mitogen-activated protein kinase 3 | ISS | PubMed:1533654 | |
| Q63844 | Mitogen-activated protein kinase 3 | ISS | PubMed:20283605 | |
| Q63844 | Mitogen-activated protein kinase 3 | ISS | 20384795 | |
| Q63844 | Mitogen-activated protein kinase 3 | ISS | 20562757 | |
| Q63844 | Mitogen-activated protein kinase 3 | ISS | 20843630 | |
| Q63844 | Mitogen-activated protein kinase 3 | ISS | OMIM:601795 | |
| Q63844 | Mitogen-activated protein kinase 3 | ISS | PubMed:8759724 | |
| Q63844 | Mitogen-activated protein kinase 3 | ISS | 9836510 | |
| Q7ZVK8 | Mitogen-activated protein kinase | ISS | PubMed:10514528 | |
| Q7ZVK8 | Mitogen-activated protein kinase | ISS | PubMed:10851062 | |
| Q7ZVK8 | Mitogen-activated protein kinase | ISS | 1169551 | |
| Q7ZVK8 | Mitogen-activated protein kinase | ISS | PubMed:11707292 | |
| Q7ZVK8 | Mitogen-activated protein kinase | ISS | PubMed:11790551 | |
| Q7ZVK8 | Mitogen-activated protein kinase | ISS | PubMed:12471242 | |
| Q7ZVK8 | Mitogen-activated protein kinase | ISS | PubMed:12787066 | |
| Q7ZVK8 | Mitogen-activated protein kinase | ISS | PubMed:9603989 | |
| Q7ZVK8 | Mitogen-activated protein kinase | ISS | PubMed:98269030 | |
| Q7ZVK8 | Mitogen-activated protein kinase | ISS | 9836510 | |
| PTHR24055:SF584 | A0A8I3PZP0 | Mitogen-activated protein kinase | ISS | PubMed:10514528 |
| A0A8I3PZP0 | Mitogen-activated protein kinase | ISS | PubMed:10851062 | |
| A0A8I3PZP0 | Mitogen-activated protein kinase | ISS | PubMed:11504705 | |
| A0A8I3PZP0 | Mitogen-activated protein kinase | ISS | 1169551 | |
| A0A8I3PZP0 | Mitogen-activated protein kinase | ISS | PubMed:11707292 | |
| A0A8I3PZP0 | Mitogen-activated protein kinase | ISS | PubMed:12787066 | |
| A0A8I3PZP0 | Mitogen-activated protein kinase | ISS | PubMed:12925581 | |
| A0A8I3PZP0 | Mitogen-activated protein kinase | ISS | 14777622 | |
| A0A8I3PZP0 | Mitogen-activated protein kinase | ISS | PubMed:1533654 | |
| A0A8I3PZP0 | Mitogen-activated protein kinase | ISS | 17127730 | |
| A0A8I3PZP0 | Mitogen-activated protein kinase | ISS | 6754632 | |
| A0A8I3PZP0 | Mitogen-activated protein kinase | ISS | PubMed:8759724 | |
| A0A8I3PZP0 | Mitogen-activated protein kinase | ISS | PubMed:9261178 | |
| A0A8I3PZP0 | Mitogen-activated protein kinase | ISS | PubMed:9393975 | |
| A0A8I3PZP0 | Mitogen-activated protein kinase | ISS | 9836510 | |
| F7E823 | Protein kinase domain-containing protein | ISS | PubMed:10514528 | |
| F7E823 | Protein kinase domain-containing protein | ISS | PubMed:10851062 | |
| F7E823 | Protein kinase domain-containing protein | ISS | PubMed:11504705 | |
| F7E823 | Protein kinase domain-containing protein | ISS | 1169551 | |
| F7E823 | Protein kinase domain-containing protein | ISS | PubMed:11707292 | |
| F7E823 | Protein kinase domain-containing protein | ISS | PubMed:12787066 | |
| F7E823 | Protein kinase domain-containing protein | ISS | 14777622 | |
| F7E823 | Protein kinase domain-containing protein | ISS | PubMed:1533654 | |
| F7E823 | Protein kinase domain-containing protein | ISS | 17127730 | |
| F7E823 | Protein kinase domain-containing protein | ISS | PubMed:8759724 | |
| F7E823 | Protein kinase domain-containing protein | ISS | PubMed:9261178 | |
| F7E823 | Protein kinase domain-containing protein | ISS | PubMed:9393975 | |
| F7E823 | Protein kinase domain-containing protein | ISS | 9836510 | |
| F7ECR3 | Mitogen-activated protein kinase | ISS | PubMed:10514528 | |
| F7ECR3 | Mitogen-activated protein kinase | ISS | PubMed:10851062 | |
| F7ECR3 | Mitogen-activated protein kinase | ISS | PubMed:11504705 | |
| F7ECR3 | Mitogen-activated protein kinase | ISS | 1169551 | |
| F7ECR3 | Mitogen-activated protein kinase | ISS | PubMed:11707292 | |
| F7ECR3 | Mitogen-activated protein kinase | ISS | PubMed:12787066 | |
| F7ECR3 | Mitogen-activated protein kinase | ISS | PubMed:12925581 | |
| F7ECR3 | Mitogen-activated protein kinase | ISS | 14777622 | |
| F7ECR3 | Mitogen-activated protein kinase | ISS | PubMed:1533654 | |
| F7ECR3 | Mitogen-activated protein kinase | ISS | 17127730 | |
| F7ECR3 | Mitogen-activated protein kinase | ISS | 6754632 | |
| F7ECR3 | Mitogen-activated protein kinase | ISS | PubMed:8759724 | |
| F7ECR3 | Mitogen-activated protein kinase | ISS | PubMed:9261178 | |
| F7ECR3 | Mitogen-activated protein kinase | ISS | PubMed:9393975 | |
| F7ECR3 | Mitogen-activated protein kinase | ISS | 9836510 | |
| F7FHD1 | Mitogen-activated protein kinase | ISS | PubMed:10514528 | |
| F7FHD1 | Mitogen-activated protein kinase | ISS | PubMed:10851062 | |
| F7FHD1 | Mitogen-activated protein kinase | ISS | PubMed:11504705 | |
| F7FHD1 | Mitogen-activated protein kinase | ISS | 1169551 | |
| F7FHD1 | Mitogen-activated protein kinase | ISS | PubMed:11707292 | |
| F7FHD1 | Mitogen-activated protein kinase | ISS | PubMed:12787066 | |
| F7FHD1 | Mitogen-activated protein kinase | ISS | PubMed:12925581 | |
| F7FHD1 | Mitogen-activated protein kinase | ISS | 14777622 | |
| F7FHD1 | Mitogen-activated protein kinase | ISS | PubMed:1533654 | |
| F7FHD1 | Mitogen-activated protein kinase | ISS | 17127730 | |
| F7FHD1 | Mitogen-activated protein kinase | ISS | 6754632 | |
| F7FHD1 | Mitogen-activated protein kinase | ISS | PubMed:8759724 | |
| F7FHD1 | Mitogen-activated protein kinase | ISS | PubMed:9261178 | |
| F7FHD1 | Mitogen-activated protein kinase | ISS | PubMed:9393975 | |
| F7FHD1 | Mitogen-activated protein kinase | ISS | 9836510 | |
| H2QLB4 | Mitogen-activated protein kinase | ISS | PubMed:10514528 | |
| H2QLB4 | Mitogen-activated protein kinase | ISS | PubMed:10851062 | |
| H2QLB4 | Mitogen-activated protein kinase | ISS | PubMed:11504705 | |
| H2QLB4 | Mitogen-activated protein kinase | ISS | 1169551 | |
| H2QLB4 | Mitogen-activated protein kinase | ISS | PubMed:11707292 | |
| H2QLB4 | Mitogen-activated protein kinase | ISS | PubMed:12787066 | |
| H2QLB4 | Mitogen-activated protein kinase | ISS | PubMed:12925581 | |
| H2QLB4 | Mitogen-activated protein kinase | ISS | 14777622 | |
| H2QLB4 | Mitogen-activated protein kinase | ISS | PubMed:1533654 | |
| H2QLB4 | Mitogen-activated protein kinase | ISS | 17127730 | |
| H2QLB4 | Mitogen-activated protein kinase | ISS | 6754632 | |
| H2QLB4 | Mitogen-activated protein kinase | ISS | PubMed:8759724 | |
| H2QLB4 | Mitogen-activated protein kinase | ISS | PubMed:9261178 | |
| H2QLB4 | Mitogen-activated protein kinase | ISS | PubMed:9393975 | |
| H2QLB4 | Mitogen-activated protein kinase | ISS | 9836510 | |
| P28482 | Mitogen-activated protein kinase 1 | IDA | PubMed:10514528 | |
| P28482 | Mitogen-activated protein kinase 1 | IDA | PubMed:10851062 | |
| P28482 | Mitogen-activated protein kinase 1 | IDA | PubMed:11504705 | |
| P28482 | Mitogen-activated protein kinase 1 | IDA | 1169551 | |
| P28482 | Mitogen-activated protein kinase 1 | IDA | PubMed:11707292 | |
| P28482 | Mitogen-activated protein kinase 1 | IDA | PubMed:12787066 | |
| P28482 | Mitogen-activated protein kinase 1 | IDA | PubMed:12925581 | |
| P28482 | Mitogen-activated protein kinase 1 | IDA | 14777622 | |
| P28482 | Mitogen-activated protein kinase 1 | IDA | PubMed:1533654 | |
| P28482 | Mitogen-activated protein kinase 1 | IDA | PubMed:8759724 | |
| P28482 | Mitogen-activated protein kinase 1 | IDA | PubMed:9261178 | |
| P28482 | Mitogen-activated protein kinase 1 | IDA | PubMed:9393975 | |
| P28482 | Mitogen-activated protein kinase 1 | IDA | 9836510 | |
| P63085 | Mitogen-activated protein kinase 1 | ISS | PubMed:10514528 | |
| P63085 | Mitogen-activated protein kinase 1 | ISS | PubMed:10851062 | |
| P63085 | Mitogen-activated protein kinase 1 | ISS | PubMed:11504705 | |
| P63085 | Mitogen-activated protein kinase 1 | ISS | 1169551 | |
| P63085 | Mitogen-activated protein kinase 1 | ISS | PubMed:11707292 | |
| P63085 | Mitogen-activated protein kinase 1 | ISS | PubMed:11790551 | |
| P63085 | Mitogen-activated protein kinase 1 | ISS | PubMed:12787066 | |
| P63085 | Mitogen-activated protein kinase 1 | ISS | PubMed:12925581 | |
| P63085 | Mitogen-activated protein kinase 1 | ISS | PubMed:1533654 | |
| P63085 | Mitogen-activated protein kinase 1 | ISS | 6754632 | |
| P63085 | Mitogen-activated protein kinase 1 | ISS | PubMed:8759724 | |
| P63085 | Mitogen-activated protein kinase 1 | ISS | PubMed:9261178 | |
| P63085 | Mitogen-activated protein kinase 1 | ISS | PubMed:9298898 | |
| P63085 | Mitogen-activated protein kinase 1 | ISS | PubMed:9393975 | |
| P63085 | Mitogen-activated protein kinase 1 | ISS | 9836510 | |
| P63086 | Mitogen-activated protein kinase 1 | ISS | PubMed:10514528 | |
| P63086 | Mitogen-activated protein kinase 1 | ISS | PubMed:10851062 | |
| P63086 | Mitogen-activated protein kinase 1 | ISS | PubMed:11504705 | |
| P63086 | Mitogen-activated protein kinase 1 | ISS | 1169551 | |
| P63086 | Mitogen-activated protein kinase 1 | ISS | PubMed:11707292 | |
| P63086 | Mitogen-activated protein kinase 1 | ISS | PubMed:11790551 | |
| P63086 | Mitogen-activated protein kinase 1 | ISS | PubMed:12787066 | |
| P63086 | Mitogen-activated protein kinase 1 | ISS | PubMed:1533654 | |
| P63086 | Mitogen-activated protein kinase 1 | ISS | PubMed:8759724 | |
| P63086 | Mitogen-activated protein kinase 1 | ISS | PubMed:9261178 | |
| P63086 | Mitogen-activated protein kinase 1 | ISS | PubMed:9298898 | |
| P63086 | Mitogen-activated protein kinase 1 | ISS | PubMed:9393975 | |
| P63086 | Mitogen-activated protein kinase 1 | ISS | PubMed:97442349 | |
| P63086 | Mitogen-activated protein kinase 1 | ISS | 9836510 | |
| Q7ZW72 | Mitogen-activated protein kinase | ISS | PubMed:10514528 | |
| Q7ZW72 | Mitogen-activated protein kinase | ISS | PubMed:10851062 | |
| Q7ZW72 | Mitogen-activated protein kinase | ISS | PubMed:11504705 | |
| Q7ZW72 | Mitogen-activated protein kinase | ISS | PubMed:11707292 | |
| Q7ZW72 | Mitogen-activated protein kinase | ISS | PubMed:11790551 | |
| Q7ZW72 | Mitogen-activated protein kinase | ISS | PubMed:12787066 | |
| Q7ZW72 | Mitogen-activated protein kinase | ISS | 1352389 | |
| Q7ZW72 | Mitogen-activated protein kinase | ISS | PubMed:1533654 | |
| Q7ZW72 | Mitogen-activated protein kinase | ISS | 17127730 | |
| Q7ZW72 | Mitogen-activated protein kinase | ISS | OMIM:176948 | |
| Q7ZW72 | Mitogen-activated protein kinase | ISS | 64894 | |
| Q7ZW72 | Mitogen-activated protein kinase | ISS | PubMed:8759724 | |
| Q7ZW72 | Mitogen-activated protein kinase | ISS | PubMed:92205337 | |
| Q7ZW72 | Mitogen-activated protein kinase | ISS | PubMed:9261178 | |
| Q7ZW72 | Mitogen-activated protein kinase | ISS | PubMed:9603989 | |
| Q7ZW72 | Mitogen-activated protein kinase | ISS | PubMed:98269030 | |
| Q7ZW72 | Mitogen-activated protein kinase | ISS | 9836510 | |
| Q7ZW72 | Mitogen-activated protein kinase | ISS | 9836512 |
