Pathway Component Details
| Name: | Ribosomal protein S6 kinase, 90kD (p90RSK) |
| Definition: | The family of 90 kDa ribosomal S6 kinases (RSK; also known as p90rsk or MAPK-activated protein kinase-1, MAPKAP-K1), was among the first substrates of ERK to be discovered and has proven to be a ubiquitous and versatile mediator of ERK signal transduction. p90RSK is composed of two functional kinase domains that are activated in a sequential manner by a series of phosphorylations. |
| Category ID: | P04541 |
| Synonyms: | |
| Upstream: |
Extracellular signal-regulated kinase
(ERK)
|
| Downstream: |
activator protein-1
(AP1)
Serum response factor (SRF) |
| Number Families/Subfamilies: | 4 |
| Number of Associated Sequences: | 22 |
| GO Molecular Function: |
-
|
| GO Biological Process: |
-
|
| GO Cellular Component: |
-
|
| PANTHER protein class: |
-
|
| References: | Medline:10411321 |
Sequence Association
| Panther Subfamily | Associated Sequence | Definition | Confidence Code | Evidence |
| PTHR24351:SF213 | A0A5F8GFF9 | Ribosomal protein S6 kinase | ISS | PubMed:15526037 |
| A0A5F8GFF9 | Ribosomal protein S6 kinase | ISS | PubMed:1922062 | |
| A0A5F8GFF9 | Ribosomal protein S6 kinase | ISS | 6755374 | |
| A0A8V0XW11 | Ribosomal protein S6 kinase | ISS | PubMed:15526037 | |
| A0A8V0XW11 | Ribosomal protein S6 kinase | ISS | PubMed:1922062 | |
| A0A8V0XW11 | Ribosomal protein S6 kinase | ISS | 6755374 | |
| F1M7N7 | Ribosomal protein S6 kinase | ISS | PubMed:15526037 | |
| F1M7N7 | Ribosomal protein S6 kinase | ISS | PubMed:1922062 | |
| F1M7N7 | Ribosomal protein S6 kinase | ISS | 6755374 | |
| F1MNR5 | Ribosomal protein S6 kinase | ISS | PubMed:15526037 | |
| F1MNR5 | Ribosomal protein S6 kinase | ISS | PubMed:1922062 | |
| F1MNR5 | Ribosomal protein S6 kinase | ISS | 6755374 | |
| Q15349 | Ribosomal protein S6 kinase alpha-2 | IDA | PubMed:15526037 | |
| Q15349 | Ribosomal protein S6 kinase alpha-2 | IDA | PubMed:1922062 | |
| Q15349 | Ribosomal protein S6 kinase alpha-2 | IDA | 6755374 | |
| Q9WUT3 | Ribosomal protein S6 kinase alpha-2 | IDA | PubMed:15526037 | |
| Q9WUT3 | Ribosomal protein S6 kinase alpha-2 | IDA | PubMed:1922062 | |
| PTHR24351:SF43 | A0A1D5QHC8 | Ribosomal protein S6 kinase | ISS | PubMed:12213813 |
| A0A1D5QHC8 | Ribosomal protein S6 kinase | ISS | PubMed:12769834 | |
| A0A1D5QHC8 | Ribosomal protein S6 kinase | ISS | PubMed:15226426 | |
| A0A1D5QHC8 | Ribosomal protein S6 kinase | ISS | PubMed:2779569 | |
| A0A1D5QHC8 | Ribosomal protein S6 kinase | ISS | 6755374 | |
| A0A1D5QHC8 | Ribosomal protein S6 kinase | ISS | PubMed:7688567 | |
| A4IFF4 | Ribosomal protein S6 kinase | ISS | PubMed:12213813 | |
| A4IFF4 | Ribosomal protein S6 kinase | ISS | PubMed:12769834 | |
| A4IFF4 | Ribosomal protein S6 kinase | ISS | PubMed:15226426 | |
| A4IFF4 | Ribosomal protein S6 kinase | ISS | PubMed:2779569 | |
| A4IFF4 | Ribosomal protein S6 kinase | ISS | 6755374 | |
| A4IFF4 | Ribosomal protein S6 kinase | ISS | PubMed:7688567 | |
| P18652 | Ribosomal protein S6 kinase 2 alpha | IDA | PubMed:2779569 | |
| P18652 | Ribosomal protein S6 kinase 2 alpha | IDA | 6755374 | |
| P18653 | Ribosomal protein S6 kinase alpha-1 | IDA | PubMed:12213813 | |
| P18653 | Ribosomal protein S6 kinase alpha-1 | IDA | PubMed:12769834 | |
| P18653 | Ribosomal protein S6 kinase alpha-1 | IDA | PubMed:15226426 | |
| P18653 | Ribosomal protein S6 kinase alpha-1 | IDA | 6755374 | |
| Q15418 | Ribosomal protein S6 kinase alpha-1 | ISS | PubMed:12213813 | |
| Q15418 | Ribosomal protein S6 kinase alpha-1 | ISS | PubMed:12769834 | |
| Q15418 | Ribosomal protein S6 kinase alpha-1 | ISS | PubMed:15226426 | |
| Q15418 | Ribosomal protein S6 kinase alpha-1 | ISS | PubMed:2779569 | |
| Q15418 | Ribosomal protein S6 kinase alpha-1 | ISS | 6755374 | |
| Q15418 | Ribosomal protein S6 kinase alpha-1 | ISS | PubMed:7688567 | |
| PTHR24351:SF58 | A0A1D5NWT4 | Ribosomal protein S6 kinase | ISS | PubMed:10480933 |
| A0A1D5NWT4 | Ribosomal protein S6 kinase | ISS | PubMed:10558991 | |
| A0A1D5NWT4 | Ribosomal protein S6 kinase | ISS | PubMed:2779569 | |
| A0A1D5NWT4 | Ribosomal protein S6 kinase | ISS | 6755374 | |
| A0A1D5QWW8 | Ribosomal protein S6 kinase | ISS | PubMed:10480933 | |
| A0A1D5QWW8 | Ribosomal protein S6 kinase | ISS | PubMed:10558991 | |
| A0A1D5QWW8 | Ribosomal protein S6 kinase | ISS | PubMed:2779569 | |
| A0A1D5QWW8 | Ribosomal protein S6 kinase | ISS | 6755374 | |
| A0A6I8NJ03 | Ribosomal protein S6 kinase | ISS | PubMed:10480933 | |
| A0A6I8NJ03 | Ribosomal protein S6 kinase | ISS | PubMed:10558991 | |
| A0A6I8NJ03 | Ribosomal protein S6 kinase | ISS | PubMed:2779569 | |
| A0A6I8NJ03 | Ribosomal protein S6 kinase | ISS | 6755374 | |
| D3Z8E0 | Ribosomal protein S6 kinase | ISS | PubMed:10480933 | |
| D3Z8E0 | Ribosomal protein S6 kinase | ISS | PubMed:10558991 | |
| D3Z8E0 | Ribosomal protein S6 kinase | ISS | PubMed:2779569 | |
| D3Z8E0 | Ribosomal protein S6 kinase | ISS | 6755374 | |
| F6YJ34 | Ribosomal protein S6 kinase | ISS | PubMed:10480933 | |
| F6YJ34 | Ribosomal protein S6 kinase | ISS | PubMed:10558991 | |
| F6YJ34 | Ribosomal protein S6 kinase | ISS | PubMed:2779569 | |
| F6YJ34 | Ribosomal protein S6 kinase | ISS | 6755374 | |
| P18654 | Ribosomal protein S6 kinase alpha-3 | IDA | PubMed:10480933 | |
| P18654 | Ribosomal protein S6 kinase alpha-3 | IDA | PubMed:2779569 | |
| P18654 | Ribosomal protein S6 kinase alpha-3 | IDA | 6755374 | |
| P51812 | Ribosomal protein S6 kinase alpha-3 | IDA | PubMed:10480933 | |
| P51812 | Ribosomal protein S6 kinase alpha-3 | IDA | PubMed:2779569 | |
| P51812 | Ribosomal protein S6 kinase alpha-3 | IDA | 6755374 | |
| PTHR24351:SF98 | Q9UK32 | Ribosomal protein S6 kinase alpha-6 | IDA | PubMed:15632195 |
| Q9UK32 | Ribosomal protein S6 kinase alpha-6 | IDA | 6755374 |
