Pathway Component Details
| Name: | Ras |
| Definition: | The Ras GTPase proteins comprise a family of self-terminating molecular switches that couple the activation of receptor and non-receptor tyrosine kinases (RTKs and NRTKs) to an elaborate array of effector pathways regulating cell proliferation, survival and differentiation. The three cellular ras genes encode four highly homologous 21 kD proteins: N-, H-, and K-ras4A and 4B. The three human ras genes represent the most frequently mutated oncogenes in human cancers. |
| Category ID: | P04547 |
| Synonyms: | |
| Upstream: | |
| Downstream: |
Raf Oncogene
(Raf)
TGFbeta-activated kinase-1 (TAK) Ral guanine nucleotide dissociation stimulator (RalGDS) Mixed lineage kinase (MLK3) p14/19 ARF T-cell lymphoma invasion and metastasis (Tiam1) Phosphatidylinositol 3-kinase (PI3K) Mitogen activated protein kinase kinase kinase (MEKK1/4) |
| Number Families/Subfamilies: | 8 |
| Number of Associated Sequences: | 28 |
| GO Molecular Function: |
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| GO Biological Process: |
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| GO Cellular Component: |
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| PANTHER protein class: |
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| References: | Medline:12573429 Medline:12642680 |
Sequence Association
