PANTHER Pathway  >   Ras Pathway >   Mitogen activated protein kinase kinase 4/7

Pathway Component Details   
Name: Mitogen activated protein kinase kinase 4/7 (MKK4/7)
Definition: The Mitogen-Activated Protein Kinase Kinases 4 and 7(MKK4, MKK7), members of the MAP kinase kinase family, directly phosphorylate and activate the c-Jun NH2-terminal kinases (JNK), in response to cellular stresses and proinflammatory cytokines.
Category ID: P04565
Synonyms:
Upstream: Mitogen activated protein kinase kinase kinase  (MEKK1/4)
Downstream: Jun kinase n-terminal kinase  (JNK)
Number Families/Subfamilies: 3
Number of Associated Sequences: 11
GO Molecular Function: -
GO Biological Process: -
GO Cellular Component: -
PANTHER protein class: -
References: Medline:10785355  Medline:15065757 

Sequence Association
Panther Subfamily Associated Sequence Definition Confidence Code Evidence
PTHR48013:SF15 A0A1D5QAU9 Mitogen-activated protein kinase kinase 4 ISS PubMed:10207617  
  A0A1D5QAU9 Mitogen-activated protein kinase kinase 4 ISS PubMed:11730323  
  A0A1D5QAU9 Mitogen-activated protein kinase kinase 4 ISS PubMed:12040174  
  A0A1D5QAU9 Mitogen-activated protein kinase kinase 4 ISS PubMed:7716521  
  A0A3Q1N7I1 Mitogen-activated protein kinase kinase 4 ISS PubMed:10207617  
  A0A3Q1N7I1 Mitogen-activated protein kinase kinase 4 ISS PubMed:11730323  
  A0A3Q1N7I1 Mitogen-activated protein kinase kinase 4 ISS PubMed:12040174  
  A0A3Q1N7I1 Mitogen-activated protein kinase kinase 4 ISS PubMed:7716521  
  B1NA68 Dual specificity mitogen-activated protein kinase kinase 4 ISS PubMed:10207617  
  B1NA68 Dual specificity mitogen-activated protein kinase kinase 4 ISS PubMed:11730323  
  B1NA68 Dual specificity mitogen-activated protein kinase kinase 4 ISS PubMed:12040174  
  B1NA68 Dual specificity mitogen-activated protein kinase kinase 4 ISS PubMed:7716521  
  P47809 Dual specificity mitogen-activated protein kinase kinase 4 ISS PubMed:10207617  
  P47809 Dual specificity mitogen-activated protein kinase kinase 4 ISS PubMed:11730323  
  P47809 Dual specificity mitogen-activated protein kinase kinase 4 ISS PubMed:12040174  
PTHR48013:SF17 A0A2I3SB47 Mitogen-activated protein kinase kinase 7 ISS PubMed:15039780  
  F7D0A6 Mitogen-activated protein kinase kinase 7 ISS PubMed:15039780  
  O14733 Dual specificity mitogen-activated protein kinase kinase 7 ISS PubMed:15039780  
  Q4KSH7 Dual specificity mitogen-activated protein kinase kinase 7 ISS PubMed:15039780  
  Q8CE90 Dual specificity mitogen-activated protein kinase kinase 7 IDA PubMed:15039780  
PTHR48013:SF29 H2QCA7 Mitogen-activated protein kinase kinase 4 ISS PubMed:10207617  
  H2QCA7 Mitogen-activated protein kinase kinase 4 ISS PubMed:11730323  
  H2QCA7 Mitogen-activated protein kinase kinase 4 ISS PubMed:12040174  
  H2QCA7 Mitogen-activated protein kinase kinase 4 ISS PubMed:7716521  
  P45985 Dual specificity mitogen-activated protein kinase kinase 4 ISS PubMed:10207617  
  P45985 Dual specificity mitogen-activated protein kinase kinase 4 ISS PubMed:11730323  
  P45985 Dual specificity mitogen-activated protein kinase kinase 4 ISS PubMed:12040174  
  P45985 Dual specificity mitogen-activated protein kinase kinase 4 ISS PubMed:7716521