Pathway Component Details
| Name: | Mitogen-activated protein kinase kinase 3 and 6 (MKK3/6) |
| Definition: | MKK3 and MKK6 are mitogen activated protein kinase kinases that specifically control the activation of the stress-induced kinase, p38MAPK. |
| Category ID: | P04568 |
| Synonyms: | |
| Upstream: |
Mixed lineage kinase
(MLK3)
TGFbeta-activated kinase-1 (TAK) Mitogen activated protein kinase kinase kinase (MEKK1/4) |
| Downstream: |
p38 mitogen activated protein kinase
(p38)
|
| Number Families/Subfamilies: | 2 |
| Number of Associated Sequences: | 14 |
| GO Molecular Function: |
-
|
| GO Biological Process: |
-
|
| GO Cellular Component: |
-
|
| PANTHER protein class: |
-
|
| References: | Medline:9768359 |
Sequence Association
| Panther Subfamily | Associated Sequence | Definition | Confidence Code | Evidence |
| PTHR48013:SF12 | A0A1D5RHD1 | Mitogen-activated protein kinase kinase 6 | RCA | |
| A0A8I3NBF5 | Mitogen-activated protein kinase kinase 6 | RCA | ||
| F7AGV5 | Mitogen-activated protein kinase kinase 6 | RCA | ||
| P52564 | Dual specificity mitogen-activated protein kinase kinase 6 | RCA | ||
| P70236 | Dual specificity mitogen-activated protein kinase kinase 6 | RCA | ||
| Q5E9X2 | Dual specificity mitogen-activated protein kinase kinase 6 | RCA | ||
| Q925D6 | Mitogen-activated protein kinase kinase 6 | RCA | ||
| Q9DGE0 | Dual specificity mitogen-activated protein kinase kinase 6 | ISS | ||
| PTHR48013:SF21 | A0A3Q1MNG1 | Mitogen-activated protein kinase kinase 3 | ISS | PubMed:10207617 |
| A0A3Q1MNG1 | Mitogen-activated protein kinase kinase 3 | ISS | PubMed:11730323 | |
| A0A3Q1MNG1 | Mitogen-activated protein kinase kinase 3 | ISS | PubMed:8900184 | |
| A0A6I8PHX7 | Mitogen-activated protein kinase kinase 3 | ISS | PubMed:11730323 | |
| A0A6I8PHX7 | Mitogen-activated protein kinase kinase 3 | ISS | PubMed:11971971 | |
| A0A6I8PHX7 | Mitogen-activated protein kinase kinase 3 | ISS | PubMed:8900184 | |
| A0A6I8PHX7 | Mitogen-activated protein kinase kinase 3 | ISS | PubMed:97059154 | |
| M0R7E7 | Mitogen activated protein kinase kinase 3 | ISS | PubMed:10207617 | |
| M0R7E7 | Mitogen activated protein kinase kinase 3 | ISS | PubMed:11730323 | |
| M0R7E7 | Mitogen activated protein kinase kinase 3 | ISS | PubMed:8900184 | |
| O09110 | Dual specificity mitogen-activated protein kinase kinase 3 | ISS | PubMed:10207617 | |
| O09110 | Dual specificity mitogen-activated protein kinase kinase 3 | ISS | PubMed:11730323 | |
| O09110 | Dual specificity mitogen-activated protein kinase kinase 3 | ISS | PubMed:8900184 | |
| P46734 | Dual specificity mitogen-activated protein kinase kinase 3 | ISS | PubMed:10207617 | |
| P46734 | Dual specificity mitogen-activated protein kinase kinase 3 | ISS | PubMed:11730323 | |
| P46734 | Dual specificity mitogen-activated protein kinase kinase 3 | ISS | PubMed:8900184 |
