Pathway Component Details
| Name: | Histon deacetylase 1 (HDAC1) |
| Definition: | Histones are nuclear proteins that bind DNA and form nucleosomes. They are directly involved with both the packaging of DNA into chromosomes and the regulation of transcription. Histone acetylation/deacetylation is a major factor in regulating chromatin structural dynamics during transcription. HDAC1 containing complex mediates deacetylation of p53, thus inhibits its transcription. |
| Category ID: | P04612 |
| Synonyms: | |
| Upstream: | |
| Downstream: | |
| Number Families/Subfamilies: | 4 |
| Number of Associated Sequences: | 10 |
| GO Molecular Function: |
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| GO Biological Process: |
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| GO Cellular Component: |
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| PANTHER protein class: |
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| References: | Medline:11099047 OMIM:601241 |
Sequence Association
| Panther Subfamily | Associated Sequence | Definition | Confidence Code | Evidence |
| PTHR10625:SF10 | A0A0D1E0Y7 | histone deacetylase | ISS | PubMed:10485845 |
| PTHR10625:SF3 | F7FJQ1 | Histone deacetylase 2 | ISS | PubMed:10485845 |
| F7FJQ1 | Histone deacetylase 2 | ISS | PubMed:12665570 | |
| PTHR10625:SF37 | A0A2R8QIW0 | Histone deacetylase | ISS | PubMed:10485845 |
| A0A2R8QIW0 | Histone deacetylase | ISS | PubMed:12665570 | |
| PTHR10625:SF49 | D3ZVU7 | Histone deacetylase 1 | ISS | PubMed:10485845 |
| D3ZVU7 | Histone deacetylase 1 | ISS | PubMed:12665570 | |
| F6Z5R3 | Histone deacetylase 1 | ISS | PubMed:10485845 | |
| F6Z5R3 | Histone deacetylase 1 | ISS | PubMed:12665570 | |
| O09106 | Histone deacetylase 1 | IDA | PubMed:10485845 | |
| O09106 | Histone deacetylase 1 | IDA | PubMed:12665570 | |
| P56517 | Histone deacetylase 1 | IDA | PubMed:10485845 | |
| P56517 | Histone deacetylase 1 | IDA | PubMed:12665570 | |
| Q13547 | Histone deacetylase 1 | IDA | PubMed:10485845 | |
| Q13547 | Histone deacetylase 1 | IDA | PubMed:12665570 | |
| Q32PJ8 | Histone deacetylase 1 | ISS | PubMed:10485845 | |
| Q32PJ8 | Histone deacetylase 1 | ISS | PubMed:12665570 | |
| Q5BL48 | Histone deacetylase | ISS | PubMed:10485845 | |
| Q5BL48 | Histone deacetylase | ISS | PubMed:12665570 |
