Pathway Component Details
| Name: | phospholipase C (PLC) |
| Definition: | Phospholipase C cleaves phosphatidylinositol bisphosphate (PIP2) to generate inositol trisphosphate (IP3) and diacylglycerol (DAG). |
| Category ID: | P05933 |
| Synonyms: | |
| Upstream: |
G-protein, alpha q subunit
(Gqalpha)
|
| Downstream: | |
| Number Families/Subfamilies: | 3 |
| Number of Associated Sequences: | 20 |
| GO Molecular Function: |
-
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| GO Biological Process: |
-
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| GO Cellular Component: |
-
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| PANTHER protein class: |
-
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| References: | OMIM:604114 OMIM:600230 OMIM:607120 |
Sequence Association
| Panther Subfamily | Associated Sequence | Definition | Confidence Code | Evidence |
| PTHR10336:SF10 | A0A2J8QDF6 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase | ISS | PubMed:10934033 |
| A0A2J8QDF6 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase | ISS | PubMed:12176394 | |
| A0A2J8QDF6 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase | ISS | PubMed:12657629 | |
| A0A2J8QDF6 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase | ISS | PubMed:12860966 | |
| A0A2J8QDF6 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase | ISS | PubMed:15611108 | |
| A0A2J8QDF6 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase | ISS | PubMed:1707501 | |
| A0A2J8QDF6 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase | ISS | PubMed:1846707 | |
| A0A2J8QDF6 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase | ISS | PubMed:7822322 | |
| A0A5F7ZVG2 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase | ISS | PubMed:10934033 | |
| A0A5F7ZVG2 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase | ISS | PubMed:12176394 | |
| A0A5F7ZVG2 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase | ISS | PubMed:12657629 | |
| A0A5F7ZVG2 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase | ISS | PubMed:12860966 | |
| A0A5F7ZVG2 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase | ISS | PubMed:15611108 | |
| A0A5F7ZVG2 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase | ISS | PubMed:1707501 | |
| A0A5F7ZVG2 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase | ISS | PubMed:1846707 | |
| A0A5F7ZVG2 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase | ISS | PubMed:7822322 | |
| A0A8I3S6D4 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase | ISS | PubMed:10934033 | |
| A0A8I3S6D4 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase | ISS | PubMed:12176394 | |
| A0A8I3S6D4 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase | ISS | PubMed:12657629 | |
| A0A8I3S6D4 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase | ISS | PubMed:12860966 | |
| A0A8I3S6D4 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase | ISS | PubMed:15611108 | |
| A0A8I3S6D4 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase | ISS | PubMed:1707501 | |
| A0A8I3S6D4 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase | ISS | PubMed:1846707 | |
| A0A8I3S6D4 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase | ISS | PubMed:7822322 | |
| A3KGF7 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 | ISS | PubMed:10934033 | |
| A3KGF7 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 | ISS | PubMed:12176394 | |
| A3KGF7 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 | ISS | PubMed:12860966 | |
| A3KGF7 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 | ISS | PubMed:1707501 | |
| A3KGF7 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 | ISS | PubMed:1846707 | |
| A3KGF7 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 | ISS | PubMed:7822322 | |
| A3KGF7 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 | ISS | PubMed:9860142 | |
| O89040 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 | RCA | PubMed:10934033 | |
| O89040 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 | RCA | PubMed:12176394 | |
| O89040 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 | RCA | PubMed:12860966 | |
| O89040 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 | RCA | PubMed:1707501 | |
| O89040 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 | RCA | PubMed:1846707 | |
| O89040 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 | RCA | PubMed:7822322 | |
| O89040 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 | RCA | PubMed:9860142 | |
| Q00722 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 | RCA | PubMed:10934033 | |
| Q00722 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 | RCA | PubMed:12176394 | |
| Q00722 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 | RCA | PubMed:12657629 | |
| Q00722 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 | RCA | PubMed:12860966 | |
| Q00722 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 | RCA | PubMed:15611108 | |
| Q00722 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 | RCA | PubMed:1707501 | |
| Q00722 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 | RCA | PubMed:1846707 | |
| Q00722 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 | RCA | PubMed:7822322 | |
| PTHR10336:SF11 | A0A2I3T8F7 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase | ISS | PubMed:10934033 |
| A0A2I3T8F7 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase | ISS | PubMed:12176394 | |
| A0A2I3T8F7 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase | ISS | PubMed:12860966 | |
| A0A2I3T8F7 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase | ISS | PubMed:1333955 | |
| A0A2I3T8F7 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase | ISS | PubMed:15611108 | |
| A0A2I3T8F7 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase | ISS | PubMed:1707501 | |
| A0A2I3T8F7 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase | ISS | PubMed:1846707 | |
| A0A2I3T8F7 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase | ISS | PubMed:7822322 | |
| A0A2I3T8F7 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase | ISS | PubMed:93203266 | |
| A0A8I3Q4W3 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase | ISS | PubMed:10934033 | |
| A0A8I3Q4W3 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase | ISS | PubMed:12176394 | |
| A0A8I3Q4W3 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase | ISS | PubMed:12860966 | |
| A0A8I3Q4W3 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase | ISS | PubMed:1333955 | |
| A0A8I3Q4W3 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase | ISS | PubMed:15611108 | |
| A0A8I3Q4W3 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase | ISS | PubMed:1707501 | |
| A0A8I3Q4W3 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase | ISS | PubMed:1846707 | |
| A0A8I3Q4W3 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase | ISS | PubMed:7822322 | |
| A0A8I3Q4W3 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase | ISS | PubMed:93203266 | |
| F6RJC0 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase | ISS | PubMed:10934033 | |
| F6RJC0 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase | ISS | PubMed:12176394 | |
| F6RJC0 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase | ISS | PubMed:12860966 | |
| F6RJC0 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase | ISS | PubMed:1333955 | |
| F6RJC0 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase | ISS | PubMed:15611108 | |
| F6RJC0 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase | ISS | PubMed:1707501 | |
| F6RJC0 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase | ISS | PubMed:1846707 | |
| F6RJC0 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase | ISS | PubMed:7822322 | |
| F6RJC0 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase | ISS | PubMed:93203266 | |
| P51432 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 | RCA | PubMed:10934033 | |
| P51432 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 | RCA | PubMed:12176394 | |
| P51432 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 | RCA | PubMed:12860966 | |
| P51432 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 | RCA | PubMed:1333955 | |
| P51432 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 | RCA | PubMed:15611108 | |
| P51432 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 | RCA | PubMed:1707501 | |
| P51432 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 | RCA | PubMed:1846707 | |
| P51432 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 | RCA | PubMed:7822322 | |
| P51432 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 | RCA | PubMed:93203266 | |
| Q01970 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 | RCA | PubMed:10934033 | |
| Q01970 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 | RCA | PubMed:12176394 | |
| Q01970 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 | RCA | PubMed:12860966 | |
| Q01970 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 | RCA | PubMed:1333955 | |
| Q01970 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 | RCA | PubMed:15611108 | |
| Q01970 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 | RCA | PubMed:1707501 | |
| Q01970 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 | RCA | PubMed:1846707 | |
| Q01970 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 | RCA | PubMed:7822322 | |
| Q99JE6 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 | RCA | PubMed:10934033 | |
| Q99JE6 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 | RCA | PubMed:12176394 | |
| Q99JE6 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 | RCA | PubMed:12860966 | |
| Q99JE6 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 | RCA | PubMed:15611108 | |
| Q99JE6 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 | RCA | PubMed:1707501 | |
| Q99JE6 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 | RCA | PubMed:1846707 | |
| Q99JE6 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 | RCA | PubMed:7822322 | |
| Q99JE6 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 | RCA | PubMed:93203266 | |
| PTHR10336:SF12 | A0A8I3PN52 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase | ISS | PubMed:10934033 |
| A0A8I3PN52 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase | ISS | PubMed:12176394 | |
| A0A8I3PN52 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase | ISS | PubMed:12860966 | |
| A0A8I3PN52 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase | ISS | PubMed:15611108 | |
| A0A8I3PN52 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase | ISS | PubMed:1707501 | |
| A0A8I3PN52 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase | ISS | PubMed:1846707 | |
| A0A8I3PN52 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase | ISS | PubMed:7822322 | |
| F6SD46 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase | ISS | PubMed:10934033 | |
| F6SD46 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase | ISS | PubMed:12176394 | |
| F6SD46 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase | ISS | PubMed:12860966 | |
| F6SD46 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase | ISS | PubMed:15611108 | |
| F6SD46 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase | ISS | PubMed:1707501 | |
| F6SD46 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase | ISS | PubMed:1846707 | |
| F6SD46 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase | ISS | PubMed:7822322 | |
| F6ZKL2 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase | ISS | PubMed:10934033 | |
| F6ZKL2 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase | ISS | PubMed:12176394 | |
| F6ZKL2 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase | ISS | PubMed:12860966 | |
| F6ZKL2 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase | ISS | PubMed:15611108 | |
| F6ZKL2 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase | ISS | PubMed:1707501 | |
| F6ZKL2 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase | ISS | PubMed:1846707 | |
| F6ZKL2 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase | ISS | PubMed:7822322 | |
| K7BA21 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase | ISS | PubMed:10934033 | |
| K7BA21 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase | ISS | PubMed:12176394 | |
| K7BA21 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase | ISS | PubMed:12860966 | |
| K7BA21 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase | ISS | PubMed:15611108 | |
| K7BA21 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase | ISS | PubMed:1707501 | |
| K7BA21 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase | ISS | PubMed:1846707 | |
| K7BA21 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase | ISS | PubMed:7822322 | |
| P10687 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 | RCA | PubMed:10934033 | |
| P10687 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 | RCA | PubMed:12176394 | |
| P10687 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 | RCA | PubMed:12860966 | |
| P10687 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 | RCA | PubMed:15611108 | |
| P10687 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 | RCA | PubMed:1707501 | |
| P10687 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 | RCA | PubMed:1846707 | |
| P10687 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 | RCA | PubMed:7822322 | |
| P10894 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 | RCA | PubMed:10934033 | |
| P10894 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 | RCA | PubMed:12176394 | |
| P10894 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 | RCA | PubMed:12860966 | |
| P10894 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 | RCA | PubMed:15611108 | |
| P10894 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 | RCA | PubMed:1707501 | |
| P10894 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 | RCA | PubMed:1846707 | |
| P10894 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 | RCA | PubMed:7822322 | |
| Q9NQ66 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 | RCA | PubMed:10934033 | |
| Q9NQ66 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 | RCA | PubMed:12176394 | |
| Q9NQ66 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 | RCA | PubMed:12860966 | |
| Q9NQ66 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 | RCA | PubMed:15611108 | |
| Q9NQ66 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 | RCA | PubMed:1707501 | |
| Q9NQ66 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 | RCA | PubMed:1846707 | |
| Q9NQ66 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 | RCA | PubMed:7822322 | |
| Q9Z1B3 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 | RCA | PubMed:10934033 | |
| Q9Z1B3 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 | RCA | PubMed:12176394 | |
| Q9Z1B3 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 | RCA | PubMed:12860966 | |
| Q9Z1B3 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 | RCA | PubMed:15611108 | |
| Q9Z1B3 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 | RCA | PubMed:1707501 | |
| Q9Z1B3 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 | RCA | PubMed:1846707 | |
| Q9Z1B3 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 | RCA | PubMed:7822322 |
