Pathway Component Details
| Name: | G protein-coupled receptor kinase 5 (GRK5) |
| Definition: | G protein-coupled receptor kinase 5 (GRK5) is a serine-threonine kinase that is constitutively associated with membranes and functions to phosphorylate agonist-activated receptors. GRK5 is widely expressed in mammalian tissues. GRK5-catalyzed receptor phosphorylation is a prerequisite for desensitization of second messenger signaling mediated by several seven transmembrane receptors. On the other hand, GRK5-mediated receptor phosphorylation is required for the b-arrestin-dependent extracellular signal-regulated kinase (ERK) activation elicited by the angiotensin II type 1a receptor (AT1aR) and the vasopressin 2 receptor (V2R). |
| Category ID: | P05940 |
| Synonyms: | |
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| Downstream: | |
| Number Families/Subfamilies: | 1 |
| Number of Associated Sequences: | 9 |
| GO Molecular Function: |
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| GO Biological Process: |
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| GO Cellular Component: |
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| PANTHER protein class: |
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| References: | OMIM:600870 |
Sequence Association
| Panther Subfamily | Associated Sequence | Definition | Confidence Code | Evidence |
| PTHR24355:SF27 | A0A5K1VNZ0 | G protein-coupled receptor kinase | ISS | PubMed:8288567 |
| A0A8I3RZ62 | G protein-coupled receptor kinase | ISS | PubMed:8288567 | |
| E1BQG4 | G protein-coupled receptor kinase | ISS | PubMed:8288567 | |
| F7DA21 | G protein-coupled receptor kinase | ISS | PubMed:8288567 | |
| K7BG59 | G protein-coupled receptor kinase | ISS | PubMed:8288567 | |
| P34947 | G protein-coupled receptor kinase 5 | RCA | PubMed:8288567 | |
| P43249 | G protein-coupled receptor kinase 5 | RCA | PubMed:8288567 | |
| Q62833 | G protein-coupled receptor kinase 5 | RCA | PubMed:8288567 | |
| Q8VEB1 | G protein-coupled receptor kinase 5 | RCA | PubMed:8288567 |
