PANTHER Pathway  >   Opioid proopiomelanocortin pathway >   adenylate cyclase

Pathway Component Details   
Name: adenylate cyclase (AC)
Definition: Signal transduction through the cell membrane requires the participation of one or more plasma membrane proteins. For many transmembrane signaling events adenylyl cyclases (ACs) are the final effector enzymes which integrate and interpret divergent signals from different pathways. The enzymatic activity of adenylyl cyclases is stimulated or inhibited in response to the activation of a large number of receptors in virtually all cells of the human body. To date, ten different mammalian isoforms of adenylyl cyclase (AC) have been cloned and characterized. Each isoform has its own distinct tissue distribution and regulatory properties, providing possibilities for different cells to respond diversely to similar stimuli. The product of the enzymatic reaction catalyzed by ACs, cyclic AMP (cAMP) has been shown to play a crucial role for a variety of fundamental physiological cell functions ranging from cell growth and differentiation, to transcriptional regulation and apoptosis.
Category ID: P06011
Synonyms:
Upstream:
Downstream:
Number Families/Subfamilies: 2
Number of Associated Sequences: 13
GO Molecular Function: -
GO Biological Process: -
GO Cellular Component: -
PANTHER protein class: -
References: Medline:11376933 

Sequence Association
Panther Subfamily Associated Sequence Definition Confidence Code Evidence
PTHR45627:SF6 A0A1D5RHE7 Adenylate cyclase type 2 ISS PubMed:12472880  
  A0A1D5RHE7 Adenylate cyclase type 2 ISS PubMed:15189569  
  A0A1D5RHE7 Adenylate cyclase type 2 ISS PubMed:1719547  
  A0A1D5RHE7 Adenylate cyclase type 2 ISS PubMed:2491850  
  F1MJV4 Adenylate cyclase type 2 ISS PubMed:12472880  
  F1MJV4 Adenylate cyclase type 2 ISS PubMed:2491850  
  F6V001 Adenylate cyclase type 2 ISS PubMed:12472880  
  F6V001 Adenylate cyclase type 2 ISS PubMed:15189569  
  F6V001 Adenylate cyclase type 2 ISS PubMed:1719547  
  F6V001 Adenylate cyclase type 2 ISS PubMed:2491850  
  F6ZAV4 Adenylate cyclase type 2 ISS PubMed:12472880  
  F6ZAV4 Adenylate cyclase type 2 ISS PubMed:15189569  
  F6ZAV4 Adenylate cyclase type 2 ISS PubMed:1719547  
  F6ZAV4 Adenylate cyclase type 2 ISS PubMed:2491850  
  P26769 Adenylate cyclase type 2 ISS PubMed:12472880  
  P26769 Adenylate cyclase type 2 ISS PubMed:2491850  
  Q08462 Adenylate cyclase type 2 ISS PubMed:12472880  
  Q08462 Adenylate cyclase type 2 ISS PubMed:15189569  
  Q08462 Adenylate cyclase type 2 ISS PubMed:1719547  
  Q08462 Adenylate cyclase type 2 ISS PubMed:2491850  
  Q80TL1 Adenylate cyclase type 2 ISS PubMed:12472880  
  Q80TL1 Adenylate cyclase type 2 ISS PubMed:15189569  
  Q80TL1 Adenylate cyclase type 2 ISS PubMed:1719547  
  Q80TL1 Adenylate cyclase type 2 ISS PubMed:2491850  
PTHR45627:SF9 A0A5F8ADK4 Adenylate cyclase type 7 ISS PubMed:11665607  
  A0A5F8ADK4 Adenylate cyclase type 7 ISS PubMed:15581358  
  A0A5F8ADK4 Adenylate cyclase type 7 ISS PubMed:2491850  
  F1LQT1 Adenylate cyclase type 7 ISS PubMed:15581358  
  F1LQT1 Adenylate cyclase type 7 ISS PubMed:2491850  
  K7ADQ0 Adenylate cyclase type 7 ISS PubMed:11665607  
  K7ADQ0 Adenylate cyclase type 7 ISS PubMed:15581358  
  K7ADQ0 Adenylate cyclase type 7 ISS PubMed:2491850  
  P51828 Adenylate cyclase type 7 ISS PubMed:11665607  
  P51828 Adenylate cyclase type 7 ISS PubMed:15581358  
  P51828 Adenylate cyclase type 7 ISS PubMed:2491850  
  P51829 Adenylate cyclase type 7 ISS PubMed:15581358  
  P51829 Adenylate cyclase type 7 ISS PubMed:2491850  
  Q29450 Adenylate cyclase type 7 ISS PubMed:15581358  
  Q29450 Adenylate cyclase type 7 ISS PubMed:2491850  
  Q29450 Adenylate cyclase type 7 ISS PubMed:8557110  
  Q29450 Adenylate cyclase type 7 ISS PubMed:96149441