Pathway Component Details
| Name: | tumor necrosis factor receptor associated factor 6 (TRAF6) |
| Definition: | This tumor necrosis factor (TNF) receptor-associated factor (TRAF) interacts with the Ser-Thr kinase IRAK1, transforming growth factor-b-activated kinase (TAK)-binding protein 1 (TAB1), and TAB2 in response to interleukin-1 (IL-1) stimulation; it contains a TRAF domain and a RING finger motif. The novel zinc finger protein TIZ may play a role during osteoclast differentiation by modulating TRAF6 signaling activity. |
| Category ID: | P06038 |
| Synonyms: | |
| Upstream: | |
| Downstream: | |
| Number Families/Subfamilies: | 2 |
| Number of Associated Sequences: | 5 |
| GO Molecular Function: |
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| GO Biological Process: |
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| GO Cellular Component: |
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| PANTHER protein class: |
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| References: | OMIM:602355 |
Sequence Association
| Panther Subfamily | Associated Sequence | Definition | Confidence Code | Evidence |
| PTHR10131:SF131 | H2Q3F3 | TNF receptor-associated factor | ISS | |
| Q9Y4K3 | TNF receptor-associated factor 6 | RCA | ||
| PTHR10131:SF152 | B5DF45 | TNF receptor-associated factor 6 | ISS | |
| B6CJY5 | TNF receptor-associated factor 6 | ISS | ||
| P70196 | TNF receptor-associated factor 6 | RCA |
