PANTHER Gene Information

Gene Symbol(s):

ECE1

Organism:

Bos taurus

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Gene Name:

Endothelin-converting enzyme 1

Gene ID:

ENSBTAG00000002977

Protein ID:

P42891

Persistent Id:

PTN007532364

Alternate Ids:

3.4.24.71(EC)	XP_005203129(refSeq)
ENSBTAG00000002977(Ensembl)	1169464(GI)
ECE1(Symbol)	ENSBTAT00000037770(Ensembl_TRS)
ECE-1(Synonym)	CAA84547(EMBL-CDS)
281133(GeneID)	Z35306(EMBL)
ENSBTAP00000037593(Ensembl_PRO)	CHEMBL2340(ChEMBL)
A2VDM9(AltAccession)	ECE1_BOVIN(UniProtKB-ID)
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PANTHER Classification

PANTHER Family:	ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED (PTHR11733)
PANTHER Subfamily:	ENDOTHELIN-CONVERTING ENZYME 1 (PTHR11733:SF130)
PANTHER GO-slim Molecular Function:	metalloendopeptidase activity
PANTHER GO-slim Biological Process:	hormone metabolic process peptide metabolic process protein processing
PANTHER GO-slim Cellular Component:	plasma membrane
PANTHER protein class:	metalloprotease

Pathway Categories:

Endothelin signaling pathway

Endothelin-coverting enzyme 1, 2, and 3

GENE ONTOLOGY DATABASE ANNOTATIONS

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GO MF Complete:	protein binding, protein homodimerization activity, metal ion binding, endopeptidase activity, metalloendopeptidase activity
GO BP Complete:	proteolysis, protein processing, peptide hormone processing
GO CC Complete:	membrane, plasma membrane

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Peptide ligand-binding receptors, Class A/1 (Rhodopsin-like receptors), Signaling by GPCR, GPCR ligand binding, Signal Transduction

Orthologs

ID	Organism	Type
HUMAN\|HGNC=3146\|UniProtKB=P42892	Homo sapiens	LDO
PANTR\|Ensembl=ENSPTRG00000000298.7\|UniProtKB=K7BJM3	Pan troglodytes	LDO
GORGO\|Ensembl=ENSGGOG00000012085.3\|UniProtKB=G3R8T0	Gorilla gorilla gorilla	LDO
MACMU\|Ensembl=ENSMMUG00000010942.4\|UniProtKB=H9FQW5	Macaca mulatta	LDO
MOUSE\|MGI=MGI=1101357\|UniProtKB=Q4PZA2	Mus musculus	LDO
RAT\|RGD=620293\|UniProtKB=P42893	Rattus norvegicus	LDO
PIG\|Ensembl=ENSSSCG00000003513.5\|UniProtKB=A0A5G2RMY7	Sus scrofa	LDO
HORSE\|Ensembl=ENSECAG00000015812.4\|UniProtKB=A0A9L0TPB8	Equus caballus	LDO
FELCA\|Ensembl=ENSFCAG00000014530.6\|UniProtKB=M3WKV5	Felis catus	LDO
CANLF\|Ensembl=ENSCAFG00845001686.1\|UniProtKB=A0A8I3MHF9	Canis lupus familiaris	LDO
MONDO\|Ensembl=ENSMODG00000016000.4\|UniProtKB=F7EYY6	Monodelphis domestica	LDO
ORNAN\|Ensembl=ENSOANG00000014757.3\|UniProtKB=F7EHA3	Ornithorhynchus anatinus	LDO
CHICK\|Ensembl=ENSGALG00010021126.1\|UniProtKB=A0A8V0ZHS1	Gallus gallus	LDO
ANOCA\|Ensembl=ENSACAG00000005393.4\|UniProtKB=H9GA87	Anolis carolinensis	LDO
XENLA\|Gene=ece1.S\|UniProtKB=A0A8J1LAP2	Xenopus laevis	LDO
XENLA\|Gene=ece1.L\|UniProtKB=A0A8J1L456	Xenopus laevis	LDO
XENTR\|Ensembl=ENSXETG00000044790\|UniProtKB=A0A803JU36	Xenopus tropicalis	LDO
ORYLA\|Ensembl=ENSORLG00000017044.2\|UniProtKB=H2MRF3	Oryzias latipes	LDO
DANRE\|ZFIN=ZDB-GENE-061110-100\|UniProtKB=A0JMP1	Danio rerio	LDO
LEPOC\|Ensembl=ENSLOCG00000003479.1\|UniProtKB=W5M719	lepisosteus oculatus	LDO
CIOIN\|Ensembl=ENSCING00000007886.3\|UniProtKB=F6TGF6	Ciona intestinalis	O
CIOIN\|Ensembl=ENSCING00000005710.3\|UniProtKB=F6U2S1	Ciona intestinalis	LDO
BRAFL\|Gene=LOC118405049\|UniProtKB=A0A9J7HLG4	Branchiostoma floridae	O
BRAFL\|Gene=LOC118405047\|UniProtKB=A0A9J7HIW7	Branchiostoma floridae	O
BRAFL\|Gene=LOC118430801\|UniProtKB=A0A9J7MAC0	Branchiostoma floridae	LDO
STRPU\|EnsemblGenome=LOC580325\|UniProtKB=A0A7M7NXK5	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC755783\|UniProtKB=A0A7M7NY20	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC578052\|UniProtKB=A0A7M7MXI0	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC580975\|UniProtKB=A0A7M7SZB7	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC583486\|UniProtKB=A0A7M7N0E0	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC594281\|UniProtKB=A0A7M7HMZ7	Strongylocentrotus purpuratus	LDO
CAEEL\|WormBase=WBGene00018278\|UniProtKB=H2KZE5	Caenorhabditis elegans	O
DROME\|FlyBase=FBgn0032613\|UniProtKB=Q9VJH0	Drosophila melanogaster	O
CAEEL\|WormBase=WBGene00017393\|UniProtKB=Q09946	Caenorhabditis elegans	O
CAEBR\|Gene_ORFName=CBG02411\|UniProtKB=A8WUD7	Caenorhabditis briggsae	O
CAEEL\|WormBase=WBGene00017842\|UniProtKB=A0A5S9MNU9	Caenorhabditis elegans	LDO
CAEBR\|WormBase=WBGene00039561\|UniProtKB=A8XY73	Caenorhabditis briggsae	LDO
PRIPA\|EnsemblGenome=WBGene00279259\|UniProtKB=A0A2A6CM30	Pristionchus pacificus	O
PRIPA\|EnsemblGenome=WBGene00104229\|UniProtKB=A0A2A6CVL4	Pristionchus pacificus	LDO
DROME\|FlyBase=FBgn0039277\|UniProtKB=Q9VBX6	Drosophila melanogaster	O
ANOGA\|EnsemblGenome=AGAP029586\|UniProtKB=A0A453Z012	Anopheles gambiae	O
IXOSC\|EnsemblGenome=ISCW006299\|UniProtKB=B7PM32	Ixodes scapularis	O
DROME\|FlyBase=FBgn0031678\|UniProtKB=Q9VMU6	Drosophila melanogaster	O
IXOSC\|EnsemblGenome=ISCW001618\|UniProtKB=B7P6U3	Ixodes scapularis	O
DROME\|FlyBase=FBgn0032442\|UniProtKB=Q9VK72	Drosophila melanogaster	O
DROME\|FlyBase=FBgn0032585\|UniProtKB=Q9VJK5	Drosophila melanogaster	O
DROME\|FlyBase=FBgn0259716\|UniProtKB=Q9VME2	Drosophila melanogaster	O
DROME\|FlyBase=FBgn0029769\|UniProtKB=Q9W4B8	Drosophila melanogaster	O
DROME\|FlyBase=FBgn0031808\|UniProtKB=Q9VME3	Drosophila melanogaster	O
DROME\|FlyBase=FBgn0031081\|UniProtKB=Q9W5Y0	Drosophila melanogaster	LDO
ANOGA\|EnsemblGenome=AGAP007796\|UniProtKB=A0A1S4GX10	Anopheles gambiae	LDO
TRICA\|EnsemblGenome=TC015284\|UniProtKB=D2A4X8	Tribolium castaneum	O
TRICA\|EnsemblGenome=TC015285\|UniProtKB=D2A4X7	Tribolium castaneum	O
TRICA\|EnsemblGenome=TC015207\|UniProtKB=D2A597	Tribolium castaneum	LDO
DAPPU\|EnsemblGenome=DAPPUDRAFT_300917\|UniProtKB=E9HFF5	Daphnia pulex	LDO
IXOSC\|EnsemblGenome=ISCW014756\|UniProtKB=B7QM96	Ixodes scapularis	LDO
HELRO\|EnsemblGenome=HelroG110566\|UniProtKB=T1EF32	helobdella robusta	LDO
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g229362\|UniProtKB=A7S4D9	Nematostella vectensis	LDO
TRIAD\|EnsemblGenome=TriadG37639\|UniProtKB=B3RTH7	Trichoplax adhaerens	O
TRIAD\|EnsemblGenome=TriadG63323\|UniProtKB=B3RZU7	Trichoplax adhaerens	LDO
EMENI\|EnsemblGenome=ANIA_03091\|UniProtKB=C8VIN1	Emericella nidulans	LDO
ASPFU\|EnsemblGenome=AFUA_3G12420\|UniProtKB=Q4WYB2	Neosartorya fumigata	LDO
SCLS1\|EnsemblGenome=SS1G_05697\|UniProtKB=A7EK51	Sclerotinia sclerotiorum	LDO
PHANO\|EnsemblGenome=SNOG_15353\|UniProtKB=Q0TYS9	Phaeosphaeria nodorum	LDO
CRYNJ\|EnsemblGenome=CNB04230\|UniProtKB=Q5KLS5	Cryptococcus neoformans	LDO
USTMA\|EnsemblGenome=UMAG_02693\|UniProtKB=A0A0D1C704	Ustilago maydis	LDO
THAPS\|EnsemblGenome=THAPSDRAFT_269863\|UniProtKB=B8LCF9	Thalassiosira pseudonana	LDO
PHYRM\|Gene=H3GEF2_PHYRM\|UniProtKB=H3GEF2	Phytophthora ramorum	O
PHYRM\|Gene=H3HBZ9_PHYRM\|UniProtKB=H3HBZ9	Phytophthora ramorum	O
PHYRM\|Gene=H3H7F1_PHYRM\|UniProtKB=H3H7F1	Phytophthora ramorum	LDO
KLENI\|Gene_ORFName=KFL_000670270\|UniProtKB=A0A1Y1HUV6	Klebsormidium nitens	LDO
METAC\|EnsemblGenome=MA_2001\|UniProtKB=Q8TPB2	Methanosarcina acetivorans	LDO
MYCTU\|Gene_OrderedLocusName=Rv0198c\|UniProtKB=I6X8R2	Mycobacterium tuberculosis	LDO
STRR6\|EnsemblGenome=spr1491\|UniProtKB=Q8DNW9	Streptococcus pneumoniae	LDO
BACTN\|EnsemblGenome=BT_3811\|UniProtKB=Q8A156	Bacteroides thetaiotaomicron	LDO
SHEON\|Gene_OrderedLocusName=SO_0429\|UniProtKB=Q8EJN4	Shewanella oneidensis	LDO
SHEON\|Gene_OrderedLocusName=SO_3844\|UniProtKB=Q8EAQ3	Shewanella oneidensis	LDO
RHOBA\|EnsemblGenome=RB9029\|UniProtKB=Q7UM68	Rhodopirellula baltica	LDO
SHEON\|Gene_OrderedLocusName=SO_0491\|UniProtKB=Q8EJH4	Shewanella oneidensis	O
XANCP\|EnsemblGenome=XCC3671\|UniProtKB=Q8P4N6	Xanthomonas campestris	O
XANCP\|EnsemblGenome=XCC2710\|UniProtKB=Q8P7A3	Xanthomonas campestris	LDO
XANCP\|EnsemblGenome=XCC2035\|UniProtKB=Q8P931	Xanthomonas campestris	O
XANCP\|EnsemblGenome=XCC2575\|UniProtKB=Q8P7N6	Xanthomonas campestris	O
XANCP\|EnsemblGenome=XCC2574\|UniProtKB=Q8P7N7	Xanthomonas campestris	O