PANTHER Gene Information   
Gene Symbol(s): Ece1
Organism: Rattus norvegicus
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Gene Name: Endothelin-converting enzyme 1
Gene ID: 620293
Protein ID: P42893
Persistent Id: PTN000199836
Alternate Ids:
CHEMBL2676(ChEMBL) 529085(GI)
ECE1_RAT(UniProtKB-ID) 620293(RGD)
CAB46528(EMBL-CDS) AJ130826(EMBL)
Ece1(Symbol) ECE-1(Synonym)
3.4.24.71(EC) Q9WUY8(AltAccession)
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PANTHER Classification
PANTHER Family: ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED (PTHR11733)
PANTHER Subfamily: ENDOTHELIN-CONVERTING ENZYME 1 (PTHR11733:SF130)  
PANTHER GO-slim Molecular Function: metalloendopeptidase activity
PANTHER GO-slim Biological Process: hormone metabolic process
peptide metabolic process
protein processing
PANTHER GO-slim Cellular Component: plasma membrane
PANTHER protein class: metalloprotease
Pathway Categories: Endothelin signaling pathway
   Endothelin-coverting enzyme 1, 2, and 3
GENE ONTOLOGY DATABASE ANNOTATIONS      Click to Expand...
GO MF Complete: zinc ion binding, identical protein binding, protein homodimerization activity, metal ion binding, endopeptidase activity, metalloendopeptidase activity
GO BP Complete: axonogenesis involved in innervation, axon guidance, response to xenobiotic stimulus, sympathetic neuron axon guidance, embryonic digit morphogenesis, positive regulation of G protein-coupled receptor signaling pathway, heart development, calcitonin catabolic process, response to hypoxia, positive regulation of receptor recycling, bradykinin catabolic process, substance P catabolic process, blood vessel diameter maintenance, positive regulation of cardiac muscle hypertrophy, response to muscle stretch, positive regulation of cAMP/PKA signal transduction, neuron projection development, semaphorin-plexin signaling pathway involved in axon guidance, response to cadmium ion, embryonic heart tube development, pharyngeal system development, regulation of blood pressure, hormone catabolic process, endothelin maturation, regulation of ERK1 and ERK2 cascade, ear development, proteolysis, gene expression, protein processing, peptide hormone processing
GO CC Complete: early endosome, endosome, Weibel-Palade body, perinuclear region of cytoplasm, secretory granule, membrane, external side of plasma membrane, vesicle, plasma membrane
REACTOME DATABASE ANNOTATIONS   Click to Expand...
Reactome Pathways: Class A/1 (Rhodopsin-like receptors), Signaling by GPCR, Peptide ligand-binding receptors, Signal Transduction, GPCR ligand binding

Orthologs