PANTHER Gene Information

Gene Symbol(s):

PRL

Organism:

Bos taurus

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Gene Name:

Prolactin

Gene ID:

ENSBTAG00000015274

Protein ID:

P01239

Persistent Id:

PTN000151940

Alternate Ids:

Q29417(AltAccession)	PRL_BOVIN(UniProtKB-ID)
130925(GI)	NP_776378(refSeq)
AAL28075(EMBL-CDS)	ENSBTAG00000015274(Ensembl)
ENSBTAP00000020313(Ensembl_PRO)	280901(GeneID)
PRL(Symbol)	PRL(Synonym)
X01452(EMBL)	ENSBTAT00000020313(Ensembl_TRS)
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PANTHER Classification

PANTHER Family:	SOMATOTROPIN,PROLACTIN (PTHR11417)
PANTHER Subfamily:	PROLACTIN (PTHR11417:SF5)
PANTHER GO-slim Molecular Function:	hormone activity
PANTHER GO-slim Biological Process:	positive regulation of cell population proliferation positive regulation of receptor signaling pathway via JAK-STAT response to nutrient levels
PANTHER GO-slim Cellular Component:	extracellular space
PANTHER protein class:	peptide hormone

Pathway Categories:

Gonadotropin-releasing hormone receptor pathway

Prolactin

GENE ONTOLOGY DATABASE ANNOTATIONS

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GO MF Complete:	hormone activity, prolactin receptor binding
GO BP Complete:	response to food, response to external biotic stimulus, positive regulation of nitric oxide biosynthetic process, peptide hormone secretion, positive regulation of endocytosis, positive regulation of canonical NF-kappaB signal transduction, positive regulation of non-canonical NF-kappaB signal transduction, lactation, positive regulation of lactation, biosynthetic process, response to mechanical stimulus, positive regulation of fatty acid biosynthetic process, inflammatory response, blastocyst formation, response to L-arginine, female pregnancy, cell surface receptor signaling pathway, positive regulation of receptor signaling pathway via JAK-STAT, regulation of meiotic cell cycle process involved in oocyte maturation, negative regulation of gene expression, mammary gland development, long-day photoperiodism, positive regulation of gene expression, negative regulation of apoptotic process, positive regulation of phagocytosis, response to nutrient levels
GO CC Complete:	endoplasmic reticulum membrane, endoplasmic reticulum lumen, extracellular space, cytosol

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Orthologs

ID	Organism	Type
HUMAN\|HGNC=9445\|UniProtKB=P01236	Homo sapiens	LDO
PANTR\|Ensembl=ENSPTRG00000017768.4\|UniProtKB=H2QSD1	Pan troglodytes	LDO
GORGO\|Ensembl=ENSGGOG00000001363.3\|UniProtKB=G3QG92	Gorilla gorilla gorilla	LDO
MACMU\|Ensembl=ENSMMUG00000020646.4\|UniProtKB=G7MQU0	Macaca mulatta	LDO
MACMU\|Gene=PRL\|UniProtKB=P55151	Macaca mulatta	LDO
MOUSE\|MGI=MGI=1206571\|UniProtKB=O54831	Mus musculus	O
RAT\|RGD=1359651\|UniProtKB=A0A8I6AU34	Rattus norvegicus	O
RAT\|RGD=620035\|UniProtKB=Q9R006	Rattus norvegicus	O
MOUSE\|MGI=MGI=1861444\|UniProtKB=Q9DAZ2	Mus musculus	O
RAT\|RGD=620118\|UniProtKB=Q9JKL9	Rattus norvegicus	O
MOUSE\|MGI=MGI=2660935\|UniProtKB=F6R3P9	Mus musculus	O
MOUSE\|MGI=MGI=97606\|UniProtKB=P18121	Mus musculus	O
MOUSE\|MGI=MGI=2660938\|UniProtKB=A0A0M6L0J6	Mus musculus	O
RAT\|RGD=2427\|UniProtKB=P21702	Rattus norvegicus	O
RAT\|RGD=2428\|UniProtKB=P34207	Rattus norvegicus	O
MOUSE\|MGI=MGI=1914560\|UniProtKB=Q9CQ58	Mus musculus	O
RAT\|RGD=619862\|UniProtKB=Q920I0	Rattus norvegicus	O
MOUSE\|MGI=MGI=1914755\|UniProtKB=Q9CRB5	Mus musculus	O
RAT\|RGD=1593943\|UniProtKB=M0R967	Rattus norvegicus	O
MOUSE\|MGI=MGI=1206579\|UniProtKB=O35257	Mus musculus	O
RAT\|RGD=3405\|UniProtKB=P24800	Rattus norvegicus	O
MOUSE\|MGI=MGI=1921438\|UniProtKB=Q9DAS4	Mus musculus	O
MOUSE\|MGI=MGI=1332225\|UniProtKB=Q9DAY2	Mus musculus	O
RAT\|RGD=620116\|UniProtKB=P33580	Rattus norvegicus	O
RAT\|RGD=708348\|UniProtKB=P33579	Rattus norvegicus	O
RAT\|RGD=620115\|UniProtKB=P33578	Rattus norvegicus	O
MOUSE\|MGI=MGI=1206587\|UniProtKB=O35256	Mus musculus	O
RAT\|RGD=3404\|UniProtKB=P09320	Rattus norvegicus	O
MOUSE\|MGI=MGI=97607\|UniProtKB=P09586	Mus musculus	O
RAT\|RGD=2429\|UniProtKB=P09321	Rattus norvegicus	O
MOUSE\|MGI=MGI=1206572\|UniProtKB=O54830	Mus musculus	O
RAT\|RGD=7695636\|UniProtKB=A0A8I6AW68	Rattus norvegicus	O
MOUSE\|MGI=MGI=894281\|UniProtKB=O54832	Mus musculus	O
MOUSE\|MGI=MGI=1920494\|UniProtKB=Q9DAV8	Mus musculus	O
RAT\|RGD=2516\|UniProtKB=Q4QRA1	Rattus norvegicus	O
MOUSE\|MGI=MGI=1341833\|UniProtKB=P04768	Mus musculus	O
MOUSE\|MGI=MGI=1858413\|UniProtKB=Q9JLV9	Mus musculus	O
MOUSE\|MGI=MGI=97618\|UniProtKB=P04095	Mus musculus	O
MOUSE\|MGI=MGI=3649927\|UniProtKB=Q5SVL9	Mus musculus	O
RAT\|RGD=1562878\|UniProtKB=Q1KZI0	Rattus norvegicus	O
MOUSE\|MGI=MGI=97619\|UniProtKB=P04769	Mus musculus	O
RAT\|RGD=621307\|UniProtKB=Q9R005	Rattus norvegicus	O
MOUSE\|MGI=MGI=106332\|UniProtKB=Q9JII2	Mus musculus	O
RAT\|RGD=1583904\|UniProtKB=Q1KZI1	Rattus norvegicus	O
RAT\|RGD=620120\|UniProtKB=Q9JII4	Rattus norvegicus	O
MOUSE\|MGI=MGI=1922846\|UniProtKB=Q8CGZ9	Mus musculus	O
RAT\|RGD=708582\|UniProtKB=Q8CJ42	Rattus norvegicus	O
MOUSE\|MGI=MGI=1351649\|UniProtKB=Q9QUN5	Mus musculus	O
RAT\|RGD=69341\|UniProtKB=Q9QUL0	Rattus norvegicus	O
MOUSE\|MGI=MGI=1914250\|UniProtKB=Q78Y73	Mus musculus	O
RAT\|RGD=731250\|UniProtKB=A0A0G2JYV6	Rattus norvegicus	O
MOUSE\|MGI=MGI=1861446\|UniProtKB=Q9JHK0	Mus musculus	O
RAT\|RGD=620121\|UniProtKB=Q9JII3	Rattus norvegicus	O
MOUSE\|MGI=MGI=97762\|UniProtKB=P06879	Mus musculus	LDO
RAT\|RGD=3403\|UniProtKB=P01237	Rattus norvegicus	LDO
PIG\|Ensembl=ENSSSCG00000039721.3\|UniProtKB=A0A286ZMS9	Sus scrofa	O
PIG\|Ensembl=ENSSSCG00005013825\|UniProtKB=P01238	Sus scrofa	LDO
HORSE\|Ensembl=ENSECAG00000000114.4\|UniProtKB=A0A9L0SHR2	Equus caballus	LDO
HORSE\|Gene=PRL\|UniProtKB=P12420	Equus caballus	LDO
FELCA\|Ensembl=ENSFCAG00000015035\|UniProtKB=P46403	Felis catus	LDO
CANLF\|Ensembl=ENSCAFG00845017595.1\|UniProtKB=E2RAF4	Canis lupus familiaris	LDO
MONDO\|Gene=PRL\|UniProtKB=O62819	Monodelphis domestica	O
MONDO\|Ensembl=ENSMODG00000011350.1\|UniProtKB=F6W2N8	Monodelphis domestica	LDO
ORNAN\|Ensembl=ENSOANG00000011127.4\|UniProtKB=F7DGX1	Ornithorhynchus anatinus	LDO
CHICK\|Ensembl=ENSGALG00010008082\|UniProtKB=P14676	Gallus gallus	LDO
ANOCA\|Ensembl=ENSACAG00000002939.3\|UniProtKB=G1KBD7	Anolis carolinensis	LDO
XENLA\|Gene=prl.2.S\|UniProtKB=A0A8J0TBC1	Xenopus laevis	O
XENLA\|Gene=LOC108695906\|UniProtKB=A0A8J0T9Y6	Xenopus laevis	O
XENTR\|Gene=LOC100498019\|UniProtKB=A0A8J1JWY0	Xenopus tropicalis	O
XENTR\|Gene=LOC100497196\|UniProtKB=A0A8J1K137	Xenopus tropicalis	O
XENTR\|Ensembl=ENSXETG00000035107\|UniProtKB=A0A6I8RB89	Xenopus tropicalis	O
XENLA\|Gene=prl.1.S\|UniProtKB=Q56A64	Xenopus laevis	O
XENLA\|Gene=prl.1.L\|UniProtKB=Q6DJG3	Xenopus laevis	LDO
XENTR\|Xenbase=XB-GENE-482866\|UniProtKB=A4QNQ2	Xenopus tropicalis	LDO
ORYLA\|Ensembl=ENSORLG00000016928.2\|UniProtKB=H2MR01	Oryzias latipes	LDO
DANRE\|ZFIN=ZDB-GENE-030513-1\|UniProtKB=Q569P7	Danio rerio	LDO