PANTHER Gene Information

Gene Symbol(s):

APH1A

Organism:

Bos taurus

View Gene in Tree

Tree

Gene Name:

Gamma-secretase subunit APH-1

Gene ID:

ENSBTAG00000021482.6

Protein ID:

A0A3Q1MBH7

Persistent Id:

PTN000306778

Alternate Ids:

539247(GeneID)	A0A3Q1MBH7_BOVIN(UniProtKB-ID)
ENSBTAT00000086383(Ensembl_TRS)	ENSBTAP00000071445(Ensembl_PRO)
ENSBTAG00000021482(Ensembl)	A0A3Q1MBH7(Synonym)
741920007(GI)	XP_010801342(refSeq)
Show All

PANTHER Classification

PANTHER Family:	GAMMA-SECRETASE SUBUNIT APH-1 (PTHR12889)
PANTHER Subfamily:	GAMMA-SECRETASE SUBUNIT APH-1A (PTHR12889:SF3)
PANTHER GO-slim Molecular Function:	protein-macromolecule adaptor activity
PANTHER GO-slim Biological Process:	protein processing Notch signaling pathway
PANTHER GO-slim Cellular Component:	endoplasmic reticulum catalytic complex plasma membrane protein complex
PANTHER protein class:	protease

Pathway Categories:

Alzheimer disease-amyloid secretase pathway

Anterior pharynx defective-1

Notch signaling pathway

Anterior pharynx defective-1

Alzheimer disease-presenilin pathway

Anterior pharynx defective-1

GENE ONTOLOGY DATABASE ANNOTATIONS

Click to Expand...

GO MF Complete:	endopeptidase activator activity, protein-macromolecule adaptor activity, enzyme binding
GO BP Complete:	Notch signaling pathway, metanephros development, membrane protein ectodomain proteolysis, Notch receptor processing, membrane protein intracellular domain proteolysis, protein processing, amyloid-beta formation
GO CC Complete:	gamma-secretase complex, endoplasmic reticulum, Golgi apparatus

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Axon guidance, EPH-ephrin mediated repulsion of cells, NRIF signals cell death from the nucleus, Signaling by Receptor Tyrosine Kinases, Regulated proteolysis of p75NTR, Cell death signalling via NRAGE, NRIF and NADE, Signal Transduction, Death Receptor Signaling, Developmental Biology, p75 NTR receptor-mediated signalling, Signaling by ERBB4, Nervous system development, Nuclear signaling by ERBB4, EPH-Ephrin signaling

Orthologs

ID	Organism	Type
HUMAN\|HGNC=29509\|UniProtKB=Q96BI3	Homo sapiens	LDO
PANTR\|Ensembl=ENSPTRG00000001250.7\|UniProtKB=H2R2D2	Pan troglodytes	LDO
GORGO\|Ensembl=ENSGGOG00000017118.3\|UniProtKB=G3RLP7	Gorilla gorilla gorilla	LDO
MACMU\|Ensembl=ENSMMUG00000021386.4\|UniProtKB=A0A5F8A987	Macaca mulatta	LDO
MOUSE\|MGI=MGI=2385110\|UniProtKB=Q8BVF7	Mus musculus	LDO
RAT\|RGD=1311546\|UniProtKB=F7EYZ3	Rattus norvegicus	LDO
PIG\|Ensembl=ENSSSCG00000028297.4\|UniProtKB=I3L8R2	Sus scrofa	LDO
PIG\|Ensembl=ENSSSCG00000028297.4\|UniProtKB=I3L8R2	Sus scrofa	LDO
HORSE\|Ensembl=ENSECAG00000012998.4\|UniProtKB=A0A9L0TG35	Equus caballus	LDO
FELCA\|Ensembl=ENSFCAG00000030589.4\|UniProtKB=M3XG97	Felis catus	LDO
CANLF\|Ensembl=ENSCAFG00845016683.1\|UniProtKB=A0A5F4DBV7	Canis lupus familiaris	LDO
MONDO\|Ensembl=ENSMODG00000018778.4\|UniProtKB=A0A5F8G294	Monodelphis domestica	LDO
ORNAN\|Ensembl=ENSOANG00000043325.1\|UniProtKB=A0A6I8P5C2	Ornithorhynchus anatinus	LDO
CHICK\|Ensembl=ENSGALG00010028642.1\|UniProtKB=A0A8V1ALF0	Gallus gallus	LDO
ANOCA\|Ensembl=ENSACAG00000008083.4\|UniProtKB=H9GDF2	Anolis carolinensis	LDO
XENLA\|Gene=aph1a.S\|UniProtKB=Q5HZF9	Xenopus laevis	O
XENLA\|Gene=aph1a.L\|UniProtKB=A0A8J0TDU1	Xenopus laevis	LDO
XENTR\|Xenbase=XB-GENE-921428\|UniProtKB=A0A803KJM5	Xenopus tropicalis	LDO
DANRE\|ZFIN=ZDB-GENE-050913-96\|UniProtKB=Q4V8Q7	Danio rerio	O
LEPOC\|Ensembl=ENSLOCG00000007436.1\|UniProtKB=W5MKW2	lepisosteus oculatus	O
CIOIN\|Ensembl=ENSCING00000002845.3\|UniProtKB=F6TN99	Ciona intestinalis	O
BRAFL\|Gene=LOC118410841\|UniProtKB=A0A9J7KQW8	Branchiostoma floridae	O
STRPU\|EnsemblGenome=LOC100893859\|UniProtKB=A0A7M7HKA1	Strongylocentrotus purpuratus	O
CAEEL\|WormBase=WBGene00000147\|UniProtKB=O45876	Caenorhabditis elegans	O
CAEBR\|Gene_ORFName=CBG25153\|UniProtKB=B0K098	Caenorhabditis briggsae	O
PRIPA\|EnsemblGenome=WBGene00304457\|UniProtKB=A0A8R1Z666	Pristionchus pacificus	O
DROME\|FlyBase=FBgn0031458\|UniProtKB=Q9VQG2	Drosophila melanogaster	O
ANOGA\|EnsemblGenome=AGAP009816\|UniProtKB=Q7PM79	Anopheles gambiae	O
TRICA\|EnsemblGenome=TC014338\|UniProtKB=D6WLF1	Tribolium castaneum	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_308872\|UniProtKB=E9HA24	Daphnia pulex	O
IXOSC\|EnsemblGenome=ISCW000544\|UniProtKB=B7P3R1	Ixodes scapularis	O
HELRO\|EnsemblGenome=HelroG98923\|UniProtKB=T1G9Q4	helobdella robusta	O
NEMVE\|Gene_ORFName=NEMVEDRAFT_v1g208914\|UniProtKB=A7S9N6	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g187301\|UniProtKB=A7S9N7	Nematostella vectensis	O
TRIAD\|EnsemblGenome=TriadG19466\|UniProtKB=B3RLD0	Trichoplax adhaerens	O
MONBE\|EnsemblGenome=MONBRDRAFT_32302\|UniProtKB=A9UYN8	Monosiga brevicollis	O
BATDJ\|Gene_ORFName=BATDEDRAFT_26332\|UniProtKB=F4P6W8	Batrachochytrium dendrobatidis	O
DICDI\|dictyBase=DDB_G0267976\|UniProtKB=Q55FS3	Dictyostelium discoideum	O
DICPU\|EnsemblGenome=DICPUDRAFT_39331\|UniProtKB=F0ZW59	Dictyostelium purpureum	O
LEIMA\|EnsemblGenome=LMJF_12_0140\|UniProtKB=Q4QGS9	Leishmania major	O
TRYB2\|Gene_ORFName=Tb927.6.1170\|UniProtKB=Q585D0	Trypanosoma brucei	O
PHYRM\|Gene=H3GHV0_PHYRM\|UniProtKB=H3GHV0	Phytophthora ramorum	O
CHLRE\|EnsemblGenome=CHLRE_13g576300v5\|UniProtKB=A8HT86	Chlamydomonas reinhardtii	O
AMBTC\|EnsemblGenome=AMTR_s00005p00230780\|UniProtKB=W1PGR6	Amborella trichopoda	O
ZOSMR\|Gene_ORFName=ZOSMA_72G00170\|UniProtKB=A0A0K9NS81	Zostera marina	O
MUSAM\|EnsemblGenome=Ma09_g02270\|UniProtKB=A0A804KF22	Musa acuminata subsp. malaccensis	O
SETIT\|EnsemblGenome=SETIT_017906mg\|UniProtKB=K3YUG0	Setaria italica	O
SORBI\|EnsemblGenome=SORBI_3004G122900\|UniProtKB=C5XZZ6	Sorghum bicolor	O
MAIZE\|EnsemblGenome=Zm00001eb237480\|UniProtKB=B4FUF4	Zea mays	O
ORYSJ\|EnsemblGenome=Os02g0272600\|UniProtKB=Q6EST3	Oryza sativa	O
BRADI\|EnsemblGenome=BRADI_3g10110v3\|UniProtKB=I1HZG3	Brachypodium distachyon	O
HORVV\|EnsemblGenome=HORVU.MOREX.r3.3HG0324130\|UniProtKB=A0A8I6Y2U6	Hordeum vulgare subsp. vulgare	O
HORVV\|EnsemblGenome=HORVU.MOREX.r3.3HG0317820\|UniProtKB=A0A8I6Y6R3	Hordeum vulgare subsp. vulgare	O
WHEAT\|EnsemblGenome=TraesCS3A02G505100\|UniProtKB=A0A3B6EQJ8	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS3B02G571000\|UniProtKB=A0A080YTY3	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS3D02G512400\|UniProtKB=A0A3B6H414	Triticum aestivum	O
NELNU\|Gene=LOC104587021\|UniProtKB=A0A1U7Z5L8	Nelumbo nucifera	O
SPIOL\|Gene=LOC110789099\|UniProtKB=A0A9R0JWB4	Spinacia oleracea	O
HELAN\|EnsemblGenome=HanXRQr2_Chr14g0630091\|UniProtKB=A0A251SFH6	Helianthus annuus	O
LACSA\|Gene_ORFName=LSAT_V11C200063240\|UniProtKB=A0A9R1XRM8	Lactuca sativa	O
ERYGU\|Gene_ORFName=MIMGU_mgv1a012457mg\|UniProtKB=A0A022Q1N3	Erythranthe guttata	O
CAPAN\|EnsemblGenome=T459_17987\|UniProtKB=A0A2G2ZDI0	Capsicum annuum	O
SOLTU\|EnsemblGenome=PGSC0003DMG400027008\|UniProtKB=M1CKH9	Solanum tuberosum	O
SOLLC\|EnsemblGenome=Solyc06g073410.3\|UniProtKB=A0A3Q7H272	Solanum lycopersicum	O
TOBAC\|Gene=LOC107832141\|UniProtKB=A0A1S4DPS8	Nicotiana tabacum	O
TOBAC\|Gene=LOC107792930\|UniProtKB=A0A1S4A252	Nicotiana tabacum	O
VITVI\|EnsemblGenome=Vitvi05g01481\|UniProtKB=D7U1N4	Vitis vinifera	O
EUCGR\|EnsemblGenome=EUGRSUZ_A00271\|UniProtKB=A0A059DBB9	Eucalyptus grandis	O
EUCGR\|EnsemblGenome=EUGRSUZ_A000742\|UniProtKB=A0A059DAR8	Eucalyptus grandis	O
BRANA\|Gene_ORFName=DARMORV10_C03P20710.1\|UniProtKB=A0A078GFP2	Brassica napus	O
BRACM\|EnsemblGenome=Bra015439\|UniProtKB=M4DG16	Brassica campestris	O
BRACM\|EnsemblGenome=Bra022841\|UniProtKB=M4E241	Brassica campestris	O
ARATH\|TAIR=locus=2061265\|UniProtKB=Q8L9G7	Arabidopsis thaliana	O
GOSHI\|Gene=LOC107927326\|UniProtKB=A0A1U8LL28	Gossypium hirsutum	O
GOSHI\|Gene=LOC107934811\|UniProtKB=A0A1U8MB47	Gossypium hirsutum	O
THECC\|EnsemblGenome=TCM_020119\|UniProtKB=A0A061ERN6	Theobroma cacao	O
CITSI\|Gene_ORFName=CISIN_1g025213mg\|UniProtKB=A0A067DXY5	Citrus sinensis	O
POPTR\|EnsemblGenome=POPTR_007G127400v3\|UniProtKB=B9HH67	Populus trichocarpa	O
MANES\|EnsemblGenome=MANES_04G042300\|UniProtKB=A0A2C9W1X7	Manihot esculenta	O
RICCO\|Gene_ORFName=RCOM_0143510\|UniProtKB=B9T796	Ricinus communis	O
SOYBN\|EnsemblGenome=GLYMA_11G128700\|UniProtKB=I1LJR0	Glycine max	O
SOYBN\|EnsemblGenome=GLYMA_12G053200\|UniProtKB=I1LQF1	Glycine max	O
MEDTR\|EnsemblGenome=MTR_4g067050\|UniProtKB=I3S3J8	Medicago truncatula	O
JUGRE\|EnsemblGenome=Jr07_17160\|UniProtKB=A0A2I4DH01	Juglans regia	O
CUCSA\|EnsemblGenome=Csa_6G041790\|UniProtKB=A0A0A0KB01	Cucumis sativus	O
PRUPE\|EnsemblGenome=PRUPE_1G190300\|UniProtKB=M5XTL9	Prunus persica	O
SELML\|EnsemblGenome=SELMODRAFT_235206\|UniProtKB=D8SV27	Selaginella moellendorffii	O
SELML\|EnsemblGenome=SELMODRAFT_104937\|UniProtKB=D8RYX4	Selaginella moellendorffii	O
PHYPA\|EnsemblGenome=Pp3c10_5780\|UniProtKB=A0A2K1JXW1	Physcomitrella patens	O
PHYPA\|EnsemblGenome=Pp3c14_4280\|UniProtKB=A9SVZ2	Physcomitrella patens	O
MARPO\|EnsemblGenome=MARPO_0042s0024\|UniProtKB=A0A2R6X1J2	Marchantia polymorpha	O
KLENI\|Gene_ORFName=KFL_007010010\|UniProtKB=A0A1Y1IQ67	Klebsormidium nitens	O