PANTHER Gene Information

Gene Symbol(s):

aph-1

Organism:

Caenorhabditis elegans

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Gene Name:

Gamma-secretase subunit aph-1

Gene ID:

WBGene00000147

Protein ID:

O45876

Persistent Id:

PTN000306793

Alternate Ids:

172747(GeneID)	VF36H2L.1(Ensembl_TRS)
NP_492469(refSeq)	37076812(GI)
APH1_CAEEL(UniProtKB-ID)	VF36H2L(WormBase_TRS)
Presenilin enhancer protein 1(Synonym)	VF36H2L.1(Ensembl_PRO)
AL021466(EMBL)	aph-1(Symbol)
WBGene00000147(Ensembl)	CAA16282(EMBL-CDS)
WBGene00000147(WormBase)	CE16526(WormBase_PRO)
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PANTHER Classification

PANTHER Family:	GAMMA-SECRETASE SUBUNIT APH-1 (PTHR12889)
PANTHER Subfamily:	GAMMA-SECRETASE SUBUNIT APH-1 (PTHR12889:SF0)
PANTHER GO-slim Molecular Function:	protein-macromolecule adaptor activity
PANTHER GO-slim Biological Process:	protein processing
PANTHER GO-slim Cellular Component:	endoplasmic reticulum catalytic complex plasma membrane protein complex
PANTHER protein class:	protease

Pathway Categories:

Alzheimer disease-amyloid secretase pathway

Anterior pharynx defective-1

Notch signaling pathway

Anterior pharynx defective-1

Alzheimer disease-presenilin pathway

Anterior pharynx defective-1

GENE ONTOLOGY DATABASE ANNOTATIONS

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GO MF Complete:	protein-macromolecule adaptor activity, molecular_function
GO BP Complete:	protein localization to cell surface, Notch signaling pathway, pharynx development, oocyte development, Notch receptor processing, positive regulation of catalytic activity, embryonic morphogenesis, embryo development ending in birth or egg hatching, cell fate commitment involved in pattern specification, cell fate commitment, protein processing
GO CC Complete:	membrane, gamma-secretase complex, endoplasmic reticulum

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

EPH-ephrin mediated repulsion of cells, EPH-Ephrin signaling, Signal Transduction, Signaling by ERBB4, Axon guidance, Nervous system development, Nuclear signaling by ERBB4, Signaling by Receptor Tyrosine Kinases, Developmental Biology

Orthologs

ID	Organism	Type
HUMAN\|HGNC=29509\|UniProtKB=Q96BI3	Homo sapiens	O
PANTR\|Ensembl=ENSPTRG00000001250.7\|UniProtKB=H2R2D2	Pan troglodytes	O
GORGO\|Ensembl=ENSGGOG00000017118.3\|UniProtKB=G3RLP7	Gorilla gorilla gorilla	O
MACMU\|Ensembl=ENSMMUG00000021386.4\|UniProtKB=A0A5F8A987	Macaca mulatta	O
MOUSE\|MGI=MGI=2385110\|UniProtKB=Q8BVF7	Mus musculus	O
RAT\|RGD=1311546\|UniProtKB=F7EYZ3	Rattus norvegicus	O
BOVIN\|Ensembl=ENSBTAG00000021482.6\|UniProtKB=A0A3Q1MBH7	Bos taurus	O
PIG\|Ensembl=ENSSSCG00000028297.4\|UniProtKB=I3L8R2	Sus scrofa	O
PIG\|Ensembl=ENSSSCG00000028297.4\|UniProtKB=I3L8R2	Sus scrofa	O
HORSE\|Ensembl=ENSECAG00000012998.4\|UniProtKB=A0A9L0TG35	Equus caballus	O
FELCA\|Ensembl=ENSFCAG00000030589.4\|UniProtKB=M3XG97	Felis catus	O
CANLF\|Ensembl=ENSCAFG00845016683.1\|UniProtKB=A0A5F4DBV7	Canis lupus familiaris	O
MONDO\|Ensembl=ENSMODG00000018778.4\|UniProtKB=A0A5F8G294	Monodelphis domestica	O
ORNAN\|Ensembl=ENSOANG00000043325.1\|UniProtKB=A0A6I8P5C2	Ornithorhynchus anatinus	O
CHICK\|Ensembl=ENSGALG00010028642.1\|UniProtKB=A0A8V1ALF0	Gallus gallus	O
ANOCA\|Ensembl=ENSACAG00000008083.4\|UniProtKB=H9GDF2	Anolis carolinensis	O
XENLA\|Gene=aph1a.S\|UniProtKB=Q5HZF9	Xenopus laevis	O
XENLA\|Gene=aph1a.L\|UniProtKB=A0A8J0TDU1	Xenopus laevis	O
XENTR\|Xenbase=XB-GENE-921428\|UniProtKB=A0A803KJM5	Xenopus tropicalis	O
CHICK\|Ensembl=ENSGALG00010012290.1\|UniProtKB=A0A8V0YLV8	Gallus gallus	O
DANRE\|ZFIN=ZDB-GENE-050913-96\|UniProtKB=Q4V8Q7	Danio rerio	O
LEPOC\|Ensembl=ENSLOCG00000007436.1\|UniProtKB=W5MKW2	lepisosteus oculatus	O
HUMAN\|HGNC=24080\|UniProtKB=Q8WW43	Homo sapiens	LDO
PANTR\|Ensembl=ENSPTRG00000007146.6\|UniProtKB=H2Q9J9	Pan troglodytes	LDO
GORGO\|Ensembl=ENSGGOG00000043020.1\|UniProtKB=A0A2I2ZC70	Gorilla gorilla gorilla	LDO
MACMU\|Ensembl=ENSMMUG00000059755.1\|UniProtKB=H9G0E6	Macaca mulatta	LDO
MOUSE\|MGI=MGI=1915568\|UniProtKB=Q9DCZ9	Mus musculus	O
MOUSE\|MGI=MGI=3522097\|UniProtKB=Q8C7N7	Mus musculus	LDO
RAT\|RGD=1597236\|UniProtKB=A0A8J8XJD4	Rattus norvegicus	O
RAT\|RGD=1562468\|UniProtKB=Q0PY50	Rattus norvegicus	LDO
BOVIN\|Ensembl=ENSBTAG00000010641.5\|UniProtKB=A0A3Q1LNM1	Bos taurus	LDO
PIG\|Ensembl=ENSSSCG00000032949.3\|UniProtKB=A0A287ALG6	Sus scrofa	LDO
HORSE\|Ensembl=ENSECAG00000001985.4\|UniProtKB=A0A5F5PUH7	Equus caballus	LDO
FELCA\|Ensembl=ENSFCAG00000040244.2\|UniProtKB=A0A5F5XBL8	Felis catus	LDO
CANLF\|Ensembl=ENSCAFG00845020653.1\|UniProtKB=A0A8I3P5D1	Canis lupus familiaris	LDO
MONDO\|Ensembl=ENSMODG00000038735.1\|UniProtKB=A0A5F8GSU1	Monodelphis domestica	LDO
ORNAN\|Ensembl=ENSOANG00000011151.4\|UniProtKB=F7D644	Ornithorhynchus anatinus	LDO
ORYLA\|Ensembl=ENSORLG00000018404.2\|UniProtKB=H2MW25	Oryzias latipes	LDO
DANRE\|ZFIN=ZDB-GENE-031118-31\|UniProtKB=Q8JHE9	Danio rerio	LDO
LEPOC\|Ensembl=ENSLOCG00000006674.1\|UniProtKB=W5MI49	lepisosteus oculatus	LDO
CIOIN\|Ensembl=ENSCING00000002845.3\|UniProtKB=F6TN99	Ciona intestinalis	LDO
BRAFL\|Gene=LOC118410841\|UniProtKB=A0A9J7KQW8	Branchiostoma floridae	LDO
STRPU\|EnsemblGenome=LOC100893859\|UniProtKB=A0A7M7HKA1	Strongylocentrotus purpuratus	LDO
CAEBR\|Gene_ORFName=CBG25153\|UniProtKB=B0K098	Caenorhabditis briggsae	LDO
PRIPA\|EnsemblGenome=WBGene00304457\|UniProtKB=A0A8R1Z666	Pristionchus pacificus	LDO
DROME\|FlyBase=FBgn0031458\|UniProtKB=Q9VQG2	Drosophila melanogaster	LDO
ANOGA\|EnsemblGenome=AGAP009816\|UniProtKB=Q7PM79	Anopheles gambiae	LDO
TRICA\|EnsemblGenome=TC014338\|UniProtKB=D6WLF1	Tribolium castaneum	LDO
DAPPU\|EnsemblGenome=DAPPUDRAFT_308872\|UniProtKB=E9HA24	Daphnia pulex	LDO
IXOSC\|EnsemblGenome=ISCW000544\|UniProtKB=B7P3R1	Ixodes scapularis	LDO
HELRO\|EnsemblGenome=HelroG98923\|UniProtKB=T1G9Q4	helobdella robusta	LDO
NEMVE\|Gene_ORFName=NEMVEDRAFT_v1g208914\|UniProtKB=A7S9N6	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g187301\|UniProtKB=A7S9N7	Nematostella vectensis	LDO
TRIAD\|EnsemblGenome=TriadG19466\|UniProtKB=B3RLD0	Trichoplax adhaerens	LDO
MONBE\|EnsemblGenome=MONBRDRAFT_32302\|UniProtKB=A9UYN8	Monosiga brevicollis	LDO
BATDJ\|Gene_ORFName=BATDEDRAFT_26332\|UniProtKB=F4P6W8	Batrachochytrium dendrobatidis	LDO
DICDI\|dictyBase=DDB_G0267976\|UniProtKB=Q55FS3	Dictyostelium discoideum	LDO
DICPU\|EnsemblGenome=DICPUDRAFT_39331\|UniProtKB=F0ZW59	Dictyostelium purpureum	LDO
LEIMA\|EnsemblGenome=LMJF_12_0140\|UniProtKB=Q4QGS9	Leishmania major	LDO
TRYB2\|Gene_ORFName=Tb927.6.1170\|UniProtKB=Q585D0	Trypanosoma brucei	LDO
PHYRM\|Gene=H3GHV0_PHYRM\|UniProtKB=H3GHV0	Phytophthora ramorum	LDO
CHLRE\|EnsemblGenome=CHLRE_13g576300v5\|UniProtKB=A8HT86	Chlamydomonas reinhardtii	LDO
AMBTC\|EnsemblGenome=AMTR_s00005p00230780\|UniProtKB=W1PGR6	Amborella trichopoda	LDO
ZOSMR\|Gene_ORFName=ZOSMA_72G00170\|UniProtKB=A0A0K9NS81	Zostera marina	LDO
MUSAM\|EnsemblGenome=Ma09_g02270\|UniProtKB=A0A804KF22	Musa acuminata subsp. malaccensis	LDO
SETIT\|EnsemblGenome=SETIT_017906mg\|UniProtKB=K3YUG0	Setaria italica	LDO
SORBI\|EnsemblGenome=SORBI_3004G122900\|UniProtKB=C5XZZ6	Sorghum bicolor	LDO
MAIZE\|EnsemblGenome=Zm00001eb237480\|UniProtKB=B4FUF4	Zea mays	LDO
ORYSJ\|EnsemblGenome=Os02g0272600\|UniProtKB=Q6EST3	Oryza sativa	LDO
BRADI\|EnsemblGenome=BRADI_3g10110v3\|UniProtKB=I1HZG3	Brachypodium distachyon	LDO
HORVV\|EnsemblGenome=HORVU.MOREX.r3.3HG0324130\|UniProtKB=A0A8I6Y2U6	Hordeum vulgare subsp. vulgare	O
HORVV\|EnsemblGenome=HORVU.MOREX.r3.3HG0317820\|UniProtKB=A0A8I6Y6R3	Hordeum vulgare subsp. vulgare	LDO
WHEAT\|EnsemblGenome=TraesCS3A02G505100\|UniProtKB=A0A3B6EQJ8	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS3B02G571000\|UniProtKB=A0A080YTY3	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS3D02G512400\|UniProtKB=A0A3B6H414	Triticum aestivum	LDO
NELNU\|Gene=LOC104587021\|UniProtKB=A0A1U7Z5L8	Nelumbo nucifera	LDO
SPIOL\|Gene=LOC110789099\|UniProtKB=A0A9R0JWB4	Spinacia oleracea	LDO
HELAN\|EnsemblGenome=HanXRQr2_Chr14g0630091\|UniProtKB=A0A251SFH6	Helianthus annuus	LDO
LACSA\|Gene_ORFName=LSAT_V11C200063240\|UniProtKB=A0A9R1XRM8	Lactuca sativa	LDO
ERYGU\|Gene_ORFName=MIMGU_mgv1a012457mg\|UniProtKB=A0A022Q1N3	Erythranthe guttata	LDO
CAPAN\|EnsemblGenome=T459_17987\|UniProtKB=A0A2G2ZDI0	Capsicum annuum	LDO
SOLTU\|EnsemblGenome=PGSC0003DMG400027008\|UniProtKB=M1CKH9	Solanum tuberosum	LDO
SOLLC\|EnsemblGenome=Solyc06g073410.3\|UniProtKB=A0A3Q7H272	Solanum lycopersicum	LDO
TOBAC\|Gene=LOC107832141\|UniProtKB=A0A1S4DPS8	Nicotiana tabacum	O
TOBAC\|Gene=LOC107792930\|UniProtKB=A0A1S4A252	Nicotiana tabacum	LDO
VITVI\|EnsemblGenome=Vitvi05g01481\|UniProtKB=D7U1N4	Vitis vinifera	LDO
EUCGR\|EnsemblGenome=EUGRSUZ_A00271\|UniProtKB=A0A059DBB9	Eucalyptus grandis	LDO
EUCGR\|EnsemblGenome=EUGRSUZ_A000742\|UniProtKB=A0A059DAR8	Eucalyptus grandis	LDO
BRANA\|Gene_ORFName=DARMORV10_C03P20710.1\|UniProtKB=A0A078GFP2	Brassica napus	LDO
BRACM\|EnsemblGenome=Bra015439\|UniProtKB=M4DG16	Brassica campestris	O
BRACM\|EnsemblGenome=Bra022841\|UniProtKB=M4E241	Brassica campestris	LDO
ARATH\|TAIR=locus=2061265\|UniProtKB=Q8L9G7	Arabidopsis thaliana	LDO
GOSHI\|Gene=LOC107927326\|UniProtKB=A0A1U8LL28	Gossypium hirsutum	O
GOSHI\|Gene=LOC107934811\|UniProtKB=A0A1U8MB47	Gossypium hirsutum	LDO
THECC\|EnsemblGenome=TCM_020119\|UniProtKB=A0A061ERN6	Theobroma cacao	LDO
CITSI\|Gene_ORFName=CISIN_1g025213mg\|UniProtKB=A0A067DXY5	Citrus sinensis	LDO
POPTR\|EnsemblGenome=POPTR_007G127400v3\|UniProtKB=B9HH67	Populus trichocarpa	LDO
MANES\|EnsemblGenome=MANES_04G042300\|UniProtKB=A0A2C9W1X7	Manihot esculenta	LDO
RICCO\|Gene_ORFName=RCOM_0143510\|UniProtKB=B9T796	Ricinus communis	LDO
SOYBN\|EnsemblGenome=GLYMA_11G128700\|UniProtKB=I1LJR0	Glycine max	LDO
SOYBN\|EnsemblGenome=GLYMA_12G053200\|UniProtKB=I1LQF1	Glycine max	LDO
MEDTR\|EnsemblGenome=MTR_4g067050\|UniProtKB=I3S3J8	Medicago truncatula	LDO
JUGRE\|EnsemblGenome=Jr07_17160\|UniProtKB=A0A2I4DH01	Juglans regia	LDO
CUCSA\|EnsemblGenome=Csa_6G041790\|UniProtKB=A0A0A0KB01	Cucumis sativus	LDO
PRUPE\|EnsemblGenome=PRUPE_1G190300\|UniProtKB=M5XTL9	Prunus persica	LDO
SELML\|EnsemblGenome=SELMODRAFT_235206\|UniProtKB=D8SV27	Selaginella moellendorffii	LDO
SELML\|EnsemblGenome=SELMODRAFT_104937\|UniProtKB=D8RYX4	Selaginella moellendorffii	LDO
PHYPA\|EnsemblGenome=Pp3c10_5780\|UniProtKB=A0A2K1JXW1	Physcomitrella patens	O
PHYPA\|EnsemblGenome=Pp3c14_4280\|UniProtKB=A9SVZ2	Physcomitrella patens	LDO
MARPO\|EnsemblGenome=MARPO_0042s0024\|UniProtKB=A0A2R6X1J2	Marchantia polymorpha	LDO
KLENI\|Gene_ORFName=KFL_007010010\|UniProtKB=A0A1Y1IQ67	Klebsormidium nitens	LDO