PANTHER Gene Information

Gene Symbol(s):

aph-1

Organism:

Drosophila melanogaster

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Gene Name:

Gamma-secretase subunit Aph-1

Gene ID:

FBgn0031458

Protein ID:

Q9VQG2

Persistent Id:

PTN000306795

Alternate Ids:

AE014134(EMBL)	FBtr0335127(Ensembl_TRS)
FBgn0031458(Ensembl)	AAK93082(EMBL-CDS)
NP_608710(refSeq)	37077998(GI)
33467(GeneID)	APH1_DROME(UniProtKB-ID)
FBpp0307126(Ensembl_PRO)	FBgn0031458(FlyBase)
aph-1(Symbol)	PSF(Synonym)
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PANTHER Classification

PANTHER Family:	GAMMA-SECRETASE SUBUNIT APH-1 (PTHR12889)
PANTHER Subfamily:	GAMMA-SECRETASE SUBUNIT APH-1 (PTHR12889:SF0)
PANTHER GO-slim Molecular Function:	protein-macromolecule adaptor activity
PANTHER GO-slim Biological Process:	protein processing
PANTHER GO-slim Cellular Component:	endoplasmic reticulum catalytic complex plasma membrane protein complex
PANTHER protein class:	protease

Pathway Categories:

Alzheimer disease-amyloid secretase pathway

Anterior pharynx defective-1

Notch signaling pathway

Anterior pharynx defective-1

Alzheimer disease-presenilin pathway

Anterior pharynx defective-1

GENE ONTOLOGY DATABASE ANNOTATIONS

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GO MF Complete:	protein-macromolecule adaptor activity
GO BP Complete:	Notch signaling pathway, Notch receptor processing, ligand-dependent, membrane protein ectodomain proteolysis, Notch receptor processing, protein processing, protein stabilization, amyloid-beta formation
GO CC Complete:	membrane, late endosome, gamma-secretase complex, endoplasmic reticulum, recycling endosome, plasma membrane

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

EPH-ephrin mediated repulsion of cells, EPH-Ephrin signaling, Axon guidance, Signaling by ERBB4, Signal Transduction, Nuclear signaling by ERBB4, Signaling by Receptor Tyrosine Kinases, Developmental Biology, Nervous system development

Orthologs

ID	Organism	Type
HUMAN\|HGNC=29509\|UniProtKB=Q96BI3	Homo sapiens	O
PANTR\|Ensembl=ENSPTRG00000001250.7\|UniProtKB=H2R2D2	Pan troglodytes	O
GORGO\|Ensembl=ENSGGOG00000017118.3\|UniProtKB=G3RLP7	Gorilla gorilla gorilla	O
MACMU\|Ensembl=ENSMMUG00000021386.4\|UniProtKB=A0A5F8A987	Macaca mulatta	O
MOUSE\|MGI=MGI=2385110\|UniProtKB=Q8BVF7	Mus musculus	O
RAT\|RGD=1311546\|UniProtKB=F7EYZ3	Rattus norvegicus	O
BOVIN\|Ensembl=ENSBTAG00000021482.6\|UniProtKB=A0A3Q1MBH7	Bos taurus	O
PIG\|Ensembl=ENSSSCG00000028297.4\|UniProtKB=I3L8R2	Sus scrofa	O
PIG\|Ensembl=ENSSSCG00000028297.4\|UniProtKB=I3L8R2	Sus scrofa	O
HORSE\|Ensembl=ENSECAG00000012998.4\|UniProtKB=A0A9L0TG35	Equus caballus	O
FELCA\|Ensembl=ENSFCAG00000030589.4\|UniProtKB=M3XG97	Felis catus	O
CANLF\|Ensembl=ENSCAFG00845016683.1\|UniProtKB=A0A5F4DBV7	Canis lupus familiaris	O
MONDO\|Ensembl=ENSMODG00000018778.4\|UniProtKB=A0A5F8G294	Monodelphis domestica	O
ORNAN\|Ensembl=ENSOANG00000043325.1\|UniProtKB=A0A6I8P5C2	Ornithorhynchus anatinus	O
CHICK\|Ensembl=ENSGALG00010028642.1\|UniProtKB=A0A8V1ALF0	Gallus gallus	O
ANOCA\|Ensembl=ENSACAG00000008083.4\|UniProtKB=H9GDF2	Anolis carolinensis	O
XENLA\|Gene=aph1a.S\|UniProtKB=Q5HZF9	Xenopus laevis	O
XENLA\|Gene=aph1a.L\|UniProtKB=A0A8J0TDU1	Xenopus laevis	O
XENTR\|Xenbase=XB-GENE-921428\|UniProtKB=A0A803KJM5	Xenopus tropicalis	O
CHICK\|Ensembl=ENSGALG00010012290.1\|UniProtKB=A0A8V0YLV8	Gallus gallus	O
DANRE\|ZFIN=ZDB-GENE-050913-96\|UniProtKB=Q4V8Q7	Danio rerio	O
LEPOC\|Ensembl=ENSLOCG00000007436.1\|UniProtKB=W5MKW2	lepisosteus oculatus	O
HUMAN\|HGNC=24080\|UniProtKB=Q8WW43	Homo sapiens	LDO
PANTR\|Ensembl=ENSPTRG00000007146.6\|UniProtKB=H2Q9J9	Pan troglodytes	LDO
GORGO\|Ensembl=ENSGGOG00000043020.1\|UniProtKB=A0A2I2ZC70	Gorilla gorilla gorilla	LDO
MACMU\|Ensembl=ENSMMUG00000059755.1\|UniProtKB=H9G0E6	Macaca mulatta	LDO
MOUSE\|MGI=MGI=1915568\|UniProtKB=Q9DCZ9	Mus musculus	O
MOUSE\|MGI=MGI=3522097\|UniProtKB=Q8C7N7	Mus musculus	LDO
RAT\|RGD=1597236\|UniProtKB=A0A8J8XJD4	Rattus norvegicus	O
RAT\|RGD=1562468\|UniProtKB=Q0PY50	Rattus norvegicus	LDO
BOVIN\|Ensembl=ENSBTAG00000010641.5\|UniProtKB=A0A3Q1LNM1	Bos taurus	LDO
PIG\|Ensembl=ENSSSCG00000032949.3\|UniProtKB=A0A287ALG6	Sus scrofa	LDO
HORSE\|Ensembl=ENSECAG00000001985.4\|UniProtKB=A0A5F5PUH7	Equus caballus	LDO
FELCA\|Ensembl=ENSFCAG00000040244.2\|UniProtKB=A0A5F5XBL8	Felis catus	LDO
CANLF\|Ensembl=ENSCAFG00845020653.1\|UniProtKB=A0A8I3P5D1	Canis lupus familiaris	LDO
MONDO\|Ensembl=ENSMODG00000038735.1\|UniProtKB=A0A5F8GSU1	Monodelphis domestica	LDO
ORNAN\|Ensembl=ENSOANG00000011151.4\|UniProtKB=F7D644	Ornithorhynchus anatinus	LDO
ORYLA\|Ensembl=ENSORLG00000018404.2\|UniProtKB=H2MW25	Oryzias latipes	LDO
DANRE\|ZFIN=ZDB-GENE-031118-31\|UniProtKB=Q8JHE9	Danio rerio	LDO
LEPOC\|Ensembl=ENSLOCG00000006674.1\|UniProtKB=W5MI49	lepisosteus oculatus	LDO
CIOIN\|Ensembl=ENSCING00000002845.3\|UniProtKB=F6TN99	Ciona intestinalis	LDO
BRAFL\|Gene=LOC118410841\|UniProtKB=A0A9J7KQW8	Branchiostoma floridae	LDO
STRPU\|EnsemblGenome=LOC100893859\|UniProtKB=A0A7M7HKA1	Strongylocentrotus purpuratus	LDO
CAEEL\|WormBase=WBGene00000147\|UniProtKB=O45876	Caenorhabditis elegans	LDO
CAEBR\|Gene_ORFName=CBG25153\|UniProtKB=B0K098	Caenorhabditis briggsae	LDO
PRIPA\|EnsemblGenome=WBGene00304457\|UniProtKB=A0A8R1Z666	Pristionchus pacificus	LDO
ANOGA\|EnsemblGenome=AGAP009816\|UniProtKB=Q7PM79	Anopheles gambiae	LDO
TRICA\|EnsemblGenome=TC014338\|UniProtKB=D6WLF1	Tribolium castaneum	LDO
DAPPU\|EnsemblGenome=DAPPUDRAFT_308872\|UniProtKB=E9HA24	Daphnia pulex	LDO
IXOSC\|EnsemblGenome=ISCW000544\|UniProtKB=B7P3R1	Ixodes scapularis	LDO
HELRO\|EnsemblGenome=HelroG98923\|UniProtKB=T1G9Q4	helobdella robusta	LDO
NEMVE\|Gene_ORFName=NEMVEDRAFT_v1g208914\|UniProtKB=A7S9N6	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g187301\|UniProtKB=A7S9N7	Nematostella vectensis	LDO
TRIAD\|EnsemblGenome=TriadG19466\|UniProtKB=B3RLD0	Trichoplax adhaerens	LDO
MONBE\|EnsemblGenome=MONBRDRAFT_32302\|UniProtKB=A9UYN8	Monosiga brevicollis	LDO
BATDJ\|Gene_ORFName=BATDEDRAFT_26332\|UniProtKB=F4P6W8	Batrachochytrium dendrobatidis	LDO
DICDI\|dictyBase=DDB_G0267976\|UniProtKB=Q55FS3	Dictyostelium discoideum	LDO
DICPU\|EnsemblGenome=DICPUDRAFT_39331\|UniProtKB=F0ZW59	Dictyostelium purpureum	LDO
LEIMA\|EnsemblGenome=LMJF_12_0140\|UniProtKB=Q4QGS9	Leishmania major	LDO
TRYB2\|Gene_ORFName=Tb927.6.1170\|UniProtKB=Q585D0	Trypanosoma brucei	LDO
PHYRM\|Gene=H3GHV0_PHYRM\|UniProtKB=H3GHV0	Phytophthora ramorum	LDO
CHLRE\|EnsemblGenome=CHLRE_13g576300v5\|UniProtKB=A8HT86	Chlamydomonas reinhardtii	LDO
AMBTC\|EnsemblGenome=AMTR_s00005p00230780\|UniProtKB=W1PGR6	Amborella trichopoda	LDO
ZOSMR\|Gene_ORFName=ZOSMA_72G00170\|UniProtKB=A0A0K9NS81	Zostera marina	LDO
MUSAM\|EnsemblGenome=Ma09_g02270\|UniProtKB=A0A804KF22	Musa acuminata subsp. malaccensis	LDO
SETIT\|EnsemblGenome=SETIT_017906mg\|UniProtKB=K3YUG0	Setaria italica	LDO
SORBI\|EnsemblGenome=SORBI_3004G122900\|UniProtKB=C5XZZ6	Sorghum bicolor	LDO
MAIZE\|EnsemblGenome=Zm00001eb237480\|UniProtKB=B4FUF4	Zea mays	LDO
ORYSJ\|EnsemblGenome=Os02g0272600\|UniProtKB=Q6EST3	Oryza sativa	LDO
BRADI\|EnsemblGenome=BRADI_3g10110v3\|UniProtKB=I1HZG3	Brachypodium distachyon	LDO
HORVV\|EnsemblGenome=HORVU.MOREX.r3.3HG0324130\|UniProtKB=A0A8I6Y2U6	Hordeum vulgare subsp. vulgare	O
HORVV\|EnsemblGenome=HORVU.MOREX.r3.3HG0317820\|UniProtKB=A0A8I6Y6R3	Hordeum vulgare subsp. vulgare	LDO
WHEAT\|EnsemblGenome=TraesCS3A02G505100\|UniProtKB=A0A3B6EQJ8	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS3B02G571000\|UniProtKB=A0A080YTY3	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS3D02G512400\|UniProtKB=A0A3B6H414	Triticum aestivum	LDO
NELNU\|Gene=LOC104587021\|UniProtKB=A0A1U7Z5L8	Nelumbo nucifera	LDO
SPIOL\|Gene=LOC110789099\|UniProtKB=A0A9R0JWB4	Spinacia oleracea	LDO
HELAN\|EnsemblGenome=HanXRQr2_Chr14g0630091\|UniProtKB=A0A251SFH6	Helianthus annuus	LDO
LACSA\|Gene_ORFName=LSAT_V11C200063240\|UniProtKB=A0A9R1XRM8	Lactuca sativa	LDO
ERYGU\|Gene_ORFName=MIMGU_mgv1a012457mg\|UniProtKB=A0A022Q1N3	Erythranthe guttata	LDO
CAPAN\|EnsemblGenome=T459_17987\|UniProtKB=A0A2G2ZDI0	Capsicum annuum	LDO
SOLTU\|EnsemblGenome=PGSC0003DMG400027008\|UniProtKB=M1CKH9	Solanum tuberosum	LDO
SOLLC\|EnsemblGenome=Solyc06g073410.3\|UniProtKB=A0A3Q7H272	Solanum lycopersicum	LDO
TOBAC\|Gene=LOC107832141\|UniProtKB=A0A1S4DPS8	Nicotiana tabacum	O
TOBAC\|Gene=LOC107792930\|UniProtKB=A0A1S4A252	Nicotiana tabacum	LDO
VITVI\|EnsemblGenome=Vitvi05g01481\|UniProtKB=D7U1N4	Vitis vinifera	LDO
EUCGR\|EnsemblGenome=EUGRSUZ_A00271\|UniProtKB=A0A059DBB9	Eucalyptus grandis	LDO
EUCGR\|EnsemblGenome=EUGRSUZ_A000742\|UniProtKB=A0A059DAR8	Eucalyptus grandis	LDO
BRANA\|Gene_ORFName=DARMORV10_C03P20710.1\|UniProtKB=A0A078GFP2	Brassica napus	LDO
BRACM\|EnsemblGenome=Bra015439\|UniProtKB=M4DG16	Brassica campestris	O
BRACM\|EnsemblGenome=Bra022841\|UniProtKB=M4E241	Brassica campestris	LDO
ARATH\|TAIR=locus=2061265\|UniProtKB=Q8L9G7	Arabidopsis thaliana	LDO
GOSHI\|Gene=LOC107927326\|UniProtKB=A0A1U8LL28	Gossypium hirsutum	O
GOSHI\|Gene=LOC107934811\|UniProtKB=A0A1U8MB47	Gossypium hirsutum	LDO
THECC\|EnsemblGenome=TCM_020119\|UniProtKB=A0A061ERN6	Theobroma cacao	LDO
CITSI\|Gene_ORFName=CISIN_1g025213mg\|UniProtKB=A0A067DXY5	Citrus sinensis	LDO
POPTR\|EnsemblGenome=POPTR_007G127400v3\|UniProtKB=B9HH67	Populus trichocarpa	LDO
MANES\|EnsemblGenome=MANES_04G042300\|UniProtKB=A0A2C9W1X7	Manihot esculenta	LDO
RICCO\|Gene_ORFName=RCOM_0143510\|UniProtKB=B9T796	Ricinus communis	LDO
SOYBN\|EnsemblGenome=GLYMA_11G128700\|UniProtKB=I1LJR0	Glycine max	LDO
SOYBN\|EnsemblGenome=GLYMA_12G053200\|UniProtKB=I1LQF1	Glycine max	LDO
MEDTR\|EnsemblGenome=MTR_4g067050\|UniProtKB=I3S3J8	Medicago truncatula	LDO
JUGRE\|EnsemblGenome=Jr07_17160\|UniProtKB=A0A2I4DH01	Juglans regia	LDO
CUCSA\|EnsemblGenome=Csa_6G041790\|UniProtKB=A0A0A0KB01	Cucumis sativus	LDO
PRUPE\|EnsemblGenome=PRUPE_1G190300\|UniProtKB=M5XTL9	Prunus persica	LDO
SELML\|EnsemblGenome=SELMODRAFT_235206\|UniProtKB=D8SV27	Selaginella moellendorffii	LDO
SELML\|EnsemblGenome=SELMODRAFT_104937\|UniProtKB=D8RYX4	Selaginella moellendorffii	LDO
PHYPA\|EnsemblGenome=Pp3c10_5780\|UniProtKB=A0A2K1JXW1	Physcomitrella patens	O
PHYPA\|EnsemblGenome=Pp3c14_4280\|UniProtKB=A9SVZ2	Physcomitrella patens	LDO
MARPO\|EnsemblGenome=MARPO_0042s0024\|UniProtKB=A0A2R6X1J2	Marchantia polymorpha	LDO
KLENI\|Gene_ORFName=KFL_007010010\|UniProtKB=A0A1Y1IQ67	Klebsormidium nitens	LDO