PANTHER Gene Information

Gene Symbol(s):

pkc-2

Organism:

Caenorhabditis elegans

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Gene Name:

Protein kinase C-like 2

Gene ID:

WBGene00004033

Protein ID:

P90980

Persistent Id:

PTN000684228

Alternate Ids:

CE30928(WormBase_PRO)	1778592(GI)
E01H11.1c(Ensembl_PRO)	E01H11.1c(WormBase_TRS)
pkc-2{ECO:0000312\|WormBase:E01H11.1b}(Symbol)	KPC2(Synonym)
CCD65289(EMBL-CDS)	E01H11.1c(Ensembl_TRS)
181166(GeneID)	U82936(EMBL)
WBGene00004033(WormBase)	Q8MQ88(AltAccession)
2.7.11.13 {ECO:0000269\|PubMed:22593072}(EC)	WBGene00004033(Ensembl)
KPC2_CAEEL(UniProtKB-ID)	NP_001024518(refSeq)
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PANTHER Classification

PANTHER Family:	SERINE/THREONINE-PROTEIN KINASE (PTHR24356)
PANTHER Subfamily:	PROTEIN KINASE C, BRAIN ISOZYME-RELATED (PTHR24356:SF390)
PANTHER GO-slim Molecular Function:	protein serine/threonine kinase activity
PANTHER GO-slim Biological Process:	peptidyl-serine phosphorylation intracellular signal transduction
PANTHER GO-slim Cellular Component:
PANTHER protein class:	non-receptor serine/threonine protein kinase

Pathway Categories:

Histamine H1 receptor mediated signaling pathway

Protein kinase C

PDGF signaling pathway

Protein kinase C

Thyrotropin-releasing hormone receptor signaling pathway

Protein kinase C

FGF signaling pathway

Protein kinase C

Angiogenesis

Protein kinase B

Apoptosis signaling pathway

Protein kinase C

VEGF signaling pathway

Protein kinase C

Endothelin signaling pathway

protein kinase c

Alzheimer disease-amyloid secretase pathway

Protein kinase C

EGF receptor signaling pathway

PKC

5HT2 type receptor mediated signaling pathway

Protein kinase C

Wnt signaling pathway

Protein Kinase C

Oxytocin receptor mediated signaling pathway

Protein kinase C

Muscarinic acetylcholine receptor 1 and 3 signaling pathway

Protein kinase C

GENE ONTOLOGY DATABASE ANNOTATIONS

Click to Expand...

GO MF Complete:	ATP binding, zinc ion binding, metal ion binding, protein kinase activity, protein serine/threonine kinase activity, calcium,diacylglycerol-dependent serine/threonine kinase activity, protein serine kinase activity, diacylglycerol-dependent serine/threonine kinase activity
GO BP Complete:	protein phosphorylation, intracellular signal transduction
GO CC Complete:	membrane, cytosol, neuronal cell body, neuron projection

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Cell Cycle, Signal Transduction, PLC beta mediated events, PCP/CE pathway, G-protein mediated events, Intracellular signaling by second messengers, Signaling by VEGF, DAG and IP3 signaling, Mitotic Prophase, Downstream signaling events of B Cell Receptor (BCR), Non-integrin membrane-ECM interactions, Adaptive Immune System, WNT5A-dependent internalization of FZD4, Response to elevated platelet cytosolic Ca2+, Syndecan interactions, VEGFR2 mediated cell proliferation, Regulation of insulin secretion, GPCR downstream signalling, Signaling by WNT, Signaling by Receptor Tyrosine Kinases, EGFR Transactivation by Gastrin, Acetylcholine regulates insulin secretion, Immune System, Beta-catenin independent WNT signaling, Disinhibition of SNARE formation, Platelet activation, signaling and aggregation, Gastrin-CREB signalling pathway via PKC and MAPK, Nuclear Envelope Breakdown, Opioid Signalling, Hemostasis, Signaling by GPCR, Signaling by SCF-KIT, G alpha (q) signalling events, Integration of energy metabolism, VEGFA-VEGFR2 Pathway, Activation of NF-kappaB in B cells, Cell Cycle, Mitotic, Regulation of KIT signaling, G alpha (i) signalling events, M Phase, Signaling by the B Cell Receptor (BCR), Metabolism, CaM pathway, Calmodulin induced events, Depolymerization of the Nuclear Lamina, Ca-dependent events, Extracellular matrix organization

Orthologs

ID	Organism	Type
HUMAN\|HGNC=9395\|UniProtKB=P05771	Homo sapiens	O
MACMU\|Ensembl=ENSMMUG00000014271.4\|UniProtKB=A0A5F8AS63	Macaca mulatta	O
MOUSE\|MGI=MGI=97596\|UniProtKB=P68404	Mus musculus	O
RAT\|RGD=3396\|UniProtKB=P68403	Rattus norvegicus	O
BOVIN\|Ensembl=ENSBTAG00000020921\|UniProtKB=P05126	Bos taurus	O
HORSE\|Ensembl=ENSECAG00000017393.4\|UniProtKB=A0A3Q2I8A3	Equus caballus	O
FELCA\|Ensembl=ENSFCAG00000011124.6\|UniProtKB=A0A2I2U7E2	Felis catus	O
CANLF\|Ensembl=ENSCAFG00845001335.1\|UniProtKB=A0A8I3MI53	Canis lupus familiaris	O
MONDO\|Ensembl=ENSMODG00000016311.4\|UniProtKB=A0A5F8GDI8	Monodelphis domestica	O
ORNAN\|Ensembl=ENSOANG00000001477.3\|UniProtKB=F7F1W5	Ornithorhynchus anatinus	O
CHICK\|Ensembl=ENSGALG00010018355.1\|UniProtKB=A0A1D5PUY5	Gallus gallus	O
XENLA\|Gene=LOC108703204\|UniProtKB=A0A1L8EQT4	Xenopus laevis	O
XENLA\|Gene=prkcb\|UniProtKB=Q7LZQ8	Xenopus laevis	O
XENLA\|Gene=LOC108701647\|UniProtKB=A0A1L8EYD3	Xenopus laevis	O
XENTR\|Xenbase=XB-GENE-486491\|UniProtKB=A8KBH6	Xenopus tropicalis	O
ORYLA\|Ensembl=ENSORLG00000008705.2\|UniProtKB=A0A3B3HC89	Oryzias latipes	O
DANRE\|ZFIN=ZDB-GENE-040426-1354\|UniProtKB=Q7T2C5	Danio rerio	O
DANRE\|ZFIN=ZDB-GENE-040426-1178\|UniProtKB=Q7SY24	Danio rerio	O
LEPOC\|Ensembl=ENSLOCG00000005443.1\|UniProtKB=W5MDV9	lepisosteus oculatus	O
HUMAN\|HGNC=9402\|UniProtKB=P05129	Homo sapiens	LDO
PANTR\|Ensembl=ENSPTRG00000011435.4\|UniProtKB=H2QH30	Pan troglodytes	LDO
GORGO\|Ensembl=ENSGGOG00000012604.3\|UniProtKB=A0A2I2YKG4	Gorilla gorilla gorilla	LDO
MACMU\|Ensembl=ENSMMUG00000007972.4\|UniProtKB=F7H3B3	Macaca mulatta	LDO
MOUSE\|MGI=MGI=97597\|UniProtKB=P63318	Mus musculus	LDO
RAT\|RGD=3397\|UniProtKB=P63319	Rattus norvegicus	LDO
BOVIN\|Gene=PRKCG\|UniProtKB=P05128	Bos taurus	LDO
PIG\|Ensembl=ENSSSCG00005038346.1\|UniProtKB=F1RNJ0	Sus scrofa	LDO
HORSE\|Ensembl=ENSECAG00000019249.3\|UniProtKB=F7CH66	Equus caballus	LDO
FELCA\|Ensembl=ENSFCAG00000001566.6\|UniProtKB=M3VWV6	Felis catus	LDO
CANLF\|Ensembl=ENSCAFG00845004184.1\|UniProtKB=E2R2X3	Canis lupus familiaris	LDO
ANOCA\|Ensembl=ENSACAG00000016368.4\|UniProtKB=H9GNA6	Anolis carolinensis	LDO
XENLA\|Gene=LOC108696776\|UniProtKB=A0A8J0TCG1	Xenopus laevis	LDO
XENLA\|Gene=LOC108697820\|UniProtKB=A0A1L8FHC4	Xenopus laevis	LDO
XENTR\|Xenbase=XB-GENE-876551\|UniProtKB=A0A6I8RBU0	Xenopus tropicalis	LDO
DANRE\|Gene=prkcg\|UniProtKB=A0A8M1QQZ0	Danio rerio	LDO
HUMAN\|HGNC=9393\|UniProtKB=P17252	Homo sapiens	O
PANTR\|Ensembl=ENSPTRG00000009557.7\|UniProtKB=H2QDQ1	Pan troglodytes	O
GORGO\|Ensembl=ENSGGOG00000015929.3\|UniProtKB=G3RIN3	Gorilla gorilla gorilla	O
MACMU\|Ensembl=ENSMMUG00000018378.4\|UniProtKB=H9EMT3	Macaca mulatta	O
MOUSE\|MGI=MGI=97595\|UniProtKB=P20444	Mus musculus	O
RAT\|RGD=3395\|UniProtKB=P05696	Rattus norvegicus	O
BOVIN\|Gene=PRKCA\|UniProtKB=P04409	Bos taurus	O
PIG\|Ensembl=ENSSSCG00000017268.5\|UniProtKB=F1RV14	Sus scrofa	O
HORSE\|Ensembl=ENSECAG00000006771.4\|UniProtKB=F6W6Q5	Equus caballus	O
FELCA\|Ensembl=ENSFCAG00000012011.6\|UniProtKB=M3WG61	Felis catus	O
CANLF\|Ensembl=ENSCAFG00845027678.1\|UniProtKB=A0A8I3PUQ8	Canis lupus familiaris	O
MONDO\|Ensembl=ENSMODG00000004147.4\|UniProtKB=F6RA79	Monodelphis domestica	O
ORNAN\|Ensembl=ENSOANG00000008060.3\|UniProtKB=F7CUS2	Ornithorhynchus anatinus	O
ANOCA\|Ensembl=ENSACAG00000000629.4\|UniProtKB=A0A803SUC5	Anolis carolinensis	O
XENLA\|Gene=prkca.L\|UniProtKB=A0A8J1LPV0	Xenopus laevis	O
XENTR\|Gene=prkca\|UniProtKB=A0A8J1IZY1	Xenopus tropicalis	O
ORYLA\|Ensembl=ENSORLG00000008825.2\|UniProtKB=H2LY64	Oryzias latipes	O
DANRE\|Gene=si=ch73-374l24.1\|UniProtKB=A0A8M3AR84	Danio rerio	O
ORYLA\|Ensembl=ENSORLG00000013842.2\|UniProtKB=H2MFH9	Oryzias latipes	O
DANRE\|Gene=prkca\|UniProtKB=A0A8M9PM31	Danio rerio	O
DANRE\|ZFIN=ZDB-GENE-050208-100\|UniProtKB=A0A2R8QIY5	Danio rerio	O
LEPOC\|Ensembl=ENSLOCG00000013639.1\|UniProtKB=W5N878	lepisosteus oculatus	O
CIOIN\|Ensembl=ENSCING00000008551.3\|UniProtKB=F6XQ16	Ciona intestinalis	LDO
CAEBR\|WormBase=WBGene00039957\|UniProtKB=A8XZI0	Caenorhabditis briggsae	O
CAEBR\|WormBase=WBGene00023650\|UniProtKB=A8WMH0	Caenorhabditis briggsae	O
CAEBR\|WormBase=WBGene00039960\|UniProtKB=A8XZH7	Caenorhabditis briggsae	O
CAEBR\|Gene_ORFName=CBG16150\|UniProtKB=A8XP04	Caenorhabditis briggsae	LDO
PRIPA\|EnsemblGenome=WBGene00110173\|UniProtKB=A0A2A6D1F3	Pristionchus pacificus	LDO
DROME\|FlyBase=FBgn0004784\|UniProtKB=P13677	Drosophila melanogaster	O
DROME\|FlyBase=FBgn0003091\|UniProtKB=P05130	Drosophila melanogaster	LDO
ANOGA\|EnsemblGenome=AGAP012252\|UniProtKB=A0A1S4H8S9	Anopheles gambiae	LDO
TRICA\|EnsemblGenome=TC032364\|UniProtKB=A0A139WLV0	Tribolium castaneum	LDO
DAPPU\|EnsemblGenome=DAPPUDRAFT_326383\|UniProtKB=E9H7K4	Daphnia pulex	LDO
IXOSC\|EnsemblGenome=ISCW020000\|UniProtKB=B7PWS6	Ixodes scapularis	LDO
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g93932\|UniProtKB=A7RUL8	Nematostella vectensis	LDO
TRIAD\|EnsemblGenome=TriadG20496\|UniProtKB=B3RQ26	Trichoplax adhaerens	LDO
MONBE\|EnsemblGenome=MONBRDRAFT_31267\|UniProtKB=A9USR5	Monosiga brevicollis	O
MONBE\|EnsemblGenome=MONBRDRAFT_10752\|UniProtKB=A9V750	Monosiga brevicollis	O
MONBE\|EnsemblGenome=MONBRDRAFT_21555\|UniProtKB=A9V1T6	Monosiga brevicollis	O
MONBE\|EnsemblGenome=MONBRDRAFT_34036\|UniProtKB=A9V9H6	Monosiga brevicollis	O
MONBE\|EnsemblGenome=MONBRDRAFT_39232\|UniProtKB=A9VD19	Monosiga brevicollis	O
MONBE\|EnsemblGenome=MONBRDRAFT_20766\|UniProtKB=A9UXQ2	Monosiga brevicollis	LDO
YEAST\|SGD=S000000201\|UniProtKB=P24583	Saccharomyces cerevisiae	LDO
EREGS\|EnsemblGenome=AGOS_ACR191C\|UniProtKB=Q75BT0	Eremothecium gossypii	LDO
CANAL\|CGD=CAL0000201435\|UniProtKB=Q5ANK2	Candida albicans	LDO
YARLI\|EnsemblGenome=YALI0_F09746g\|UniProtKB=Q6C292	Yarrowia lipolytica	LDO
EMENI\|EnsemblGenome=ANIA_00106\|UniProtKB=C8VQM0	Emericella nidulans	LDO
NEUCR\|EnsemblGenome=NCU06544\|UniProtKB=P87253	Neurospora crassa	LDO
PHANO\|EnsemblGenome=SNOG_07073\|UniProtKB=Q0UME1	Phaeosphaeria nodorum	LDO
SCHPO\|PomBase=SPAC17G8.14c\|UniProtKB=P36582	Schizosaccharomyces pombe	O
SCHPO\|PomBase=SPBC12D12.04c\|UniProtKB=P36583	Schizosaccharomyces pombe	LDO
CRYNJ\|EnsemblGenome=CNE01630\|UniProtKB=Q5KH12	Cryptococcus neoformans	O
CRYNJ\|EnsemblGenome=CNC03300\|UniProtKB=Q5KKE3	Cryptococcus neoformans	LDO
USTMA\|EnsemblGenome=UMAG_15023\|UniProtKB=A0A0D1DRE2	Ustilago maydis	LDO
PUCGT\|EnsemblGenome=PGTG_12641\|UniProtKB=E3KRH5	Puccinia graminis	LDO
BATDJ\|Gene_ORFName=BATDEDRAFT_15370\|UniProtKB=F4NTP5	Batrachochytrium dendrobatidis	O
BATDJ\|Gene_ORFName=BATDEDRAFT_19449\|UniProtKB=F4P170	Batrachochytrium dendrobatidis	LDO
ENTH1\|EnsemblGenome=CL6EHI_125820\|UniProtKB=C4LVW8	Entamoeba histolytica	O
ENTH1\|EnsemblGenome=CL6EHI_097620\|UniProtKB=C4M933	Entamoeba histolytica	O
ENTH1\|EnsemblGenome=CL6EHI_188930\|UniProtKB=C4M2W0	Entamoeba histolytica	O
ENTH1\|EnsemblGenome=CL6EHI_044470\|UniProtKB=B1N2G7	Entamoeba histolytica	O
ENTH1\|EnsemblGenome=CL6EHI_042150\|UniProtKB=C4M4G9	Entamoeba histolytica	O
ENTH1\|EnsemblGenome=CL6EHI_053040\|UniProtKB=C4M3C2	Entamoeba histolytica	O
ENTH1\|Gene_ORFName=EHI_138540\|UniProtKB=A0A8U0WPI4	Entamoeba histolytica	O
DICDI\|dictyBase=DDB_G0288795\|UniProtKB=Q54IF2	Dictyostelium discoideum	O
DICPU\|EnsemblGenome=DICPUDRAFT_149347\|UniProtKB=F0ZDG7	Dictyostelium purpureum	O
DICDI\|dictyBase=DDB_G0268620\|UniProtKB=P54644	Dictyostelium discoideum	O
DICPU\|EnsemblGenome=DICPUDRAFT_152431\|UniProtKB=F0ZLC3	Dictyostelium purpureum	O
DICPU\|EnsemblGenome=DICPUDRAFT_38849\|UniProtKB=F0ZVB0	Dictyostelium purpureum	O
LEIMA\|EnsemblGenome=LMJF_30_0800\|UniProtKB=Q4Q7M5	Leishmania major	O
TRYB2\|Gene_ORFName=Tb11.01.2290\|UniProtKB=Q383M7	Trypanosoma brucei	O
TRYB2\|Gene_ORFName=Tb927.3.2690\|UniProtKB=Q582Y1	Trypanosoma brucei	O
GIAIC\|EnsemblGenome=GL50803_11364\|UniProtKB=E2RTY0	Giardia intestinalis	O
TRIV3\|Gene_ORFName=TVAG_195270\|UniProtKB=A2FLX7	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_324020\|UniProtKB=A2F4A4	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_430560\|UniProtKB=A2E382	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_316050\|UniProtKB=A2FAW3	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_447920\|UniProtKB=A2DS63	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_047250\|UniProtKB=A2FHJ2	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_267830\|UniProtKB=A2DLD2	Trichomonas vaginalis	O
SACS2\|EnsemblGenome=SSO3207\|UniProtKB=Q97U18	Sulfolobus solfataricus	O