PANTHER Gene Information

Gene Symbol(s):

PRKCA

Organism:

Pan troglodytes

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Gene Name:

Protein kinase C

Gene ID:

ENSPTRG00000009557.7

Protein ID:

H2QDQ1

Persistent Id:

PTN000684203

Alternate Ids:

AACZ04070114(EMBL)	H2QDQ1_PANTR(UniProtKB-ID)
ENSPTRT00000017527(Ensembl_TRS)	H2QDQ1(Synonym)
332848863(GI)	XM_003315686(refSeq)
JAA10314(EMBL-CDS)	ENSPTRG00000009557(Ensembl)
ENSPTRP00000016236(Ensembl_PRO)	454832(GeneID)
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PANTHER Classification

PANTHER Family:	SERINE/THREONINE-PROTEIN KINASE (PTHR24356)
PANTHER Subfamily:	PROTEIN KINASE C ALPHA TYPE (PTHR24356:SF193)
PANTHER GO-slim Molecular Function:	protein serine/threonine kinase activity
PANTHER GO-slim Biological Process:	peptidyl-serine phosphorylation intracellular signal transduction
PANTHER GO-slim Cellular Component:
PANTHER protein class:	non-receptor serine/threonine protein kinase

Pathway Categories:

Gonadotropin-releasing hormone receptor pathway

PKCs

Histamine H1 receptor mediated signaling pathway

Protein kinase C

Apoptosis signaling pathway

Protein kinase C

Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway

Protein kinase C

Angiotensin II-stimulated signaling through G proteins and beta-arrestin

protein kinase C

Wnt signaling pathway

Protein Kinase C

Muscarinic acetylcholine receptor 1 and 3 signaling pathway

Protein kinase C

Oxytocin receptor mediated signaling pathway

Protein kinase C

PDGF signaling pathway

Protein kinase C

FGF signaling pathway

Protein kinase C

Thyrotropin-releasing hormone receptor signaling pathway

Protein kinase C

Angiogenesis

Protein kinase B

Gonadotropin-releasing hormone receptor pathway

PKCs(3)

Alpha adrenergic receptor signaling pathway

protein kinase C

CCKR signaling map

PKCalpha

Endothelin signaling pathway

protein kinase c

VEGF signaling pathway

Protein kinase C

Alzheimer disease-amyloid secretase pathway

Protein kinase C

EGF receptor signaling pathway

PKC

5HT2 type receptor mediated signaling pathway

Protein kinase C

GENE ONTOLOGY DATABASE ANNOTATIONS

Click to Expand...

GO MF Complete:	diacylglycerol-dependent, calcium-independent serine/threonine kinase activity, ATP binding, zinc ion binding, metal ion binding, protein kinase activity, protein serine/threonine kinase activity, calcium,diacylglycerol-dependent serine/threonine kinase activity, protein serine kinase activity, diacylglycerol-dependent serine/threonine kinase activity, enzyme binding, histone H3T6 kinase activity
GO BP Complete:	negative regulation of glial cell apoptotic process, regulation of platelet aggregation, positive regulation of angiotensin-activated signaling pathway, cell adhesion, positive regulation of cell adhesion, post-translational protein modification, positive regulation of blood vessel endothelial cell migration, positive regulation of angiogenesis, positive regulation of mitotic cell cycle, desmosome assembly, chromatin remodeling, angiogenesis, apoptotic process, response to interleukin-1, positive regulation of endothelial cell proliferation, positive regulation of lipopolysaccharide-mediated signaling pathway, positive regulation of endothelial cell migration, regulation of primary metabolic process, intracellular signal transduction, positive regulation of cell migration
GO CC Complete:	nucleus, mitochondrial membrane, cytoplasm, ciliary basal body, mitochondrion, membrane, cytosol, endoplasmic reticulum, plasma membrane

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Orthologs

ID	Organism	Type
HUMAN\|HGNC=9393\|UniProtKB=P17252	Homo sapiens	LDO
GORGO\|Ensembl=ENSGGOG00000015929.3\|UniProtKB=G3RIN3	Gorilla gorilla gorilla	LDO
MACMU\|Ensembl=ENSMMUG00000018378.4\|UniProtKB=H9EMT3	Macaca mulatta	LDO
MOUSE\|MGI=MGI=97595\|UniProtKB=P20444	Mus musculus	LDO
RAT\|RGD=3395\|UniProtKB=P05696	Rattus norvegicus	LDO
BOVIN\|Gene=PRKCA\|UniProtKB=P04409	Bos taurus	LDO
PIG\|Ensembl=ENSSSCG00000017268.5\|UniProtKB=F1RV14	Sus scrofa	LDO
HORSE\|Ensembl=ENSECAG00000006771.4\|UniProtKB=F6W6Q5	Equus caballus	LDO
FELCA\|Ensembl=ENSFCAG00000012011.6\|UniProtKB=M3WG61	Felis catus	LDO
CANLF\|Ensembl=ENSCAFG00845027678.1\|UniProtKB=A0A8I3PUQ8	Canis lupus familiaris	LDO
MONDO\|Ensembl=ENSMODG00000004147.4\|UniProtKB=F6RA79	Monodelphis domestica	LDO
ORNAN\|Ensembl=ENSOANG00000008060.3\|UniProtKB=F7CUS2	Ornithorhynchus anatinus	LDO
ANOCA\|Ensembl=ENSACAG00000000629.4\|UniProtKB=A0A803SUC5	Anolis carolinensis	LDO
XENLA\|Gene=prkca.L\|UniProtKB=A0A8J1LPV0	Xenopus laevis	LDO
XENTR\|Gene=prkca\|UniProtKB=A0A8J1IZY1	Xenopus tropicalis	LDO
ORYLA\|Ensembl=ENSORLG00000008825.2\|UniProtKB=H2LY64	Oryzias latipes	O
DANRE\|Gene=si=ch73-374l24.1\|UniProtKB=A0A8M3AR84	Danio rerio	O
ORYLA\|Ensembl=ENSORLG00000013842.2\|UniProtKB=H2MFH9	Oryzias latipes	LDO
DANRE\|Gene=prkca\|UniProtKB=A0A8M9PM31	Danio rerio	LDO
DANRE\|ZFIN=ZDB-GENE-050208-100\|UniProtKB=A0A2R8QIY5	Danio rerio	LDO
LEPOC\|Ensembl=ENSLOCG00000013639.1\|UniProtKB=W5N878	lepisosteus oculatus	LDO
CIOIN\|Ensembl=ENSCING00000008551.3\|UniProtKB=F6XQ16	Ciona intestinalis	O
CAEEL\|WormBase=WBGene00004033\|UniProtKB=P90980	Caenorhabditis elegans	O
CAEBR\|WormBase=WBGene00039957\|UniProtKB=A8XZI0	Caenorhabditis briggsae	O
CAEBR\|WormBase=WBGene00023650\|UniProtKB=A8WMH0	Caenorhabditis briggsae	O
CAEBR\|WormBase=WBGene00039960\|UniProtKB=A8XZH7	Caenorhabditis briggsae	O
CAEBR\|Gene_ORFName=CBG16150\|UniProtKB=A8XP04	Caenorhabditis briggsae	O
PRIPA\|EnsemblGenome=WBGene00110173\|UniProtKB=A0A2A6D1F3	Pristionchus pacificus	O
DROME\|FlyBase=FBgn0004784\|UniProtKB=P13677	Drosophila melanogaster	O
DROME\|FlyBase=FBgn0003091\|UniProtKB=P05130	Drosophila melanogaster	O
ANOGA\|EnsemblGenome=AGAP012252\|UniProtKB=A0A1S4H8S9	Anopheles gambiae	O
TRICA\|EnsemblGenome=TC032364\|UniProtKB=A0A139WLV0	Tribolium castaneum	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_326383\|UniProtKB=E9H7K4	Daphnia pulex	O
IXOSC\|EnsemblGenome=ISCW020000\|UniProtKB=B7PWS6	Ixodes scapularis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g93932\|UniProtKB=A7RUL8	Nematostella vectensis	O
TRIAD\|EnsemblGenome=TriadG20496\|UniProtKB=B3RQ26	Trichoplax adhaerens	O
MONBE\|EnsemblGenome=MONBRDRAFT_31267\|UniProtKB=A9USR5	Monosiga brevicollis	O
MONBE\|EnsemblGenome=MONBRDRAFT_10752\|UniProtKB=A9V750	Monosiga brevicollis	O
MONBE\|EnsemblGenome=MONBRDRAFT_21555\|UniProtKB=A9V1T6	Monosiga brevicollis	O
MONBE\|EnsemblGenome=MONBRDRAFT_34036\|UniProtKB=A9V9H6	Monosiga brevicollis	O
MONBE\|EnsemblGenome=MONBRDRAFT_39232\|UniProtKB=A9VD19	Monosiga brevicollis	O
MONBE\|EnsemblGenome=MONBRDRAFT_20766\|UniProtKB=A9UXQ2	Monosiga brevicollis	O
YEAST\|SGD=S000000201\|UniProtKB=P24583	Saccharomyces cerevisiae	O
EREGS\|EnsemblGenome=AGOS_ACR191C\|UniProtKB=Q75BT0	Eremothecium gossypii	O
CANAL\|CGD=CAL0000201435\|UniProtKB=Q5ANK2	Candida albicans	O
YARLI\|EnsemblGenome=YALI0_F09746g\|UniProtKB=Q6C292	Yarrowia lipolytica	O
EMENI\|EnsemblGenome=ANIA_00106\|UniProtKB=C8VQM0	Emericella nidulans	O
NEUCR\|EnsemblGenome=NCU06544\|UniProtKB=P87253	Neurospora crassa	O
PHANO\|EnsemblGenome=SNOG_07073\|UniProtKB=Q0UME1	Phaeosphaeria nodorum	O
SCHPO\|PomBase=SPAC17G8.14c\|UniProtKB=P36582	Schizosaccharomyces pombe	O
SCHPO\|PomBase=SPBC12D12.04c\|UniProtKB=P36583	Schizosaccharomyces pombe	O
CRYNJ\|EnsemblGenome=CNE01630\|UniProtKB=Q5KH12	Cryptococcus neoformans	O
CRYNJ\|EnsemblGenome=CNC03300\|UniProtKB=Q5KKE3	Cryptococcus neoformans	O
USTMA\|EnsemblGenome=UMAG_15023\|UniProtKB=A0A0D1DRE2	Ustilago maydis	O
PUCGT\|EnsemblGenome=PGTG_12641\|UniProtKB=E3KRH5	Puccinia graminis	O
BATDJ\|Gene_ORFName=BATDEDRAFT_15370\|UniProtKB=F4NTP5	Batrachochytrium dendrobatidis	O
BATDJ\|Gene_ORFName=BATDEDRAFT_19449\|UniProtKB=F4P170	Batrachochytrium dendrobatidis	O
ENTH1\|EnsemblGenome=CL6EHI_125820\|UniProtKB=C4LVW8	Entamoeba histolytica	O
ENTH1\|EnsemblGenome=CL6EHI_097620\|UniProtKB=C4M933	Entamoeba histolytica	O
ENTH1\|EnsemblGenome=CL6EHI_188930\|UniProtKB=C4M2W0	Entamoeba histolytica	O
ENTH1\|EnsemblGenome=CL6EHI_044470\|UniProtKB=B1N2G7	Entamoeba histolytica	O
ENTH1\|EnsemblGenome=CL6EHI_042150\|UniProtKB=C4M4G9	Entamoeba histolytica	O
ENTH1\|EnsemblGenome=CL6EHI_053040\|UniProtKB=C4M3C2	Entamoeba histolytica	O
ENTH1\|Gene_ORFName=EHI_138540\|UniProtKB=A0A8U0WPI4	Entamoeba histolytica	O
DICDI\|dictyBase=DDB_G0288795\|UniProtKB=Q54IF2	Dictyostelium discoideum	O
DICPU\|EnsemblGenome=DICPUDRAFT_149347\|UniProtKB=F0ZDG7	Dictyostelium purpureum	O
DICDI\|dictyBase=DDB_G0268620\|UniProtKB=P54644	Dictyostelium discoideum	O
DICPU\|EnsemblGenome=DICPUDRAFT_152431\|UniProtKB=F0ZLC3	Dictyostelium purpureum	O
DICPU\|EnsemblGenome=DICPUDRAFT_38849\|UniProtKB=F0ZVB0	Dictyostelium purpureum	O
LEIMA\|EnsemblGenome=LMJF_30_0800\|UniProtKB=Q4Q7M5	Leishmania major	O
TRYB2\|Gene_ORFName=Tb11.01.2290\|UniProtKB=Q383M7	Trypanosoma brucei	O
TRYB2\|Gene_ORFName=Tb927.3.2690\|UniProtKB=Q582Y1	Trypanosoma brucei	O
GIAIC\|EnsemblGenome=GL50803_11364\|UniProtKB=E2RTY0	Giardia intestinalis	O
TRIV3\|Gene_ORFName=TVAG_195270\|UniProtKB=A2FLX7	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_324020\|UniProtKB=A2F4A4	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_430560\|UniProtKB=A2E382	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_316050\|UniProtKB=A2FAW3	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_447920\|UniProtKB=A2DS63	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_047250\|UniProtKB=A2FHJ2	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_267830\|UniProtKB=A2DLD2	Trichomonas vaginalis	O
SACS2\|EnsemblGenome=SSO3207\|UniProtKB=Q97U18	Sulfolobus solfataricus	O