PANTHER Gene Information   
Gene Symbol(s): rbx-1
Organism: Caenorhabditis elegans
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Gene Name: RING-box protein 1
Gene ID: WBGene00004320
Protein ID: Q23457
Persistent Id: PTN000129882
Alternate Ids:
WBGene00004320(Ensembl) RBX1(Synonym)
NM_073095(refSeq) CAA94801(EMBL-CDS)
Z70757(EMBL) 37537923(GI)
WBGene00004320(WormBase) 179358(GeneID)
ZK287(WormBase_TRS) CE06614(WormBase_PRO)
RBX1_CAEEL(UniProtKB-ID) ZK287.5(Ensembl_PRO)
Q8WSQ1(AltAccession) ZK287.5(Ensembl_TRS)
rbx-1(Symbol)
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PANTHER Classification
PANTHER Family: RING BOX (PTHR11210)
PANTHER Subfamily: E3 UBIQUITIN-PROTEIN LIGASE RBX1 (PTHR11210:SF2)  
PANTHER GO-slim Molecular Function: ubiquitin protein ligase activity
cullin family protein binding
PANTHER GO-slim Biological Process: ubiquitin-dependent protein catabolic process
protein ubiquitination
PANTHER GO-slim Cellular Component: nucleus
cullin-RING ubiquitin ligase complex
PANTHER protein class: ubiquitin-protein ligase
Pathway Categories: No pathway information available
GENE ONTOLOGY DATABASE ANNOTATIONS      Click to Expand...
GO MF Complete: zinc ion binding, ubiquitin protein ligase activity, metal ion binding, cullin family protein binding
GO BP Complete: cell division, negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage, negative regulation of DNA damage response, signal transduction by p53 class mediator, meiotic cell cycle, anterior/posterior axis specification, embryo, programmed cell death involved in cell development, sister chromosome movement towards spindle pole involved in meiotic sister chromatid segregation, positive regulation of metaphase/anaphase transition of meiotic cell cycle, ubiquitin-dependent protein catabolic process, protein ubiquitination
GO CC Complete: nucleus, cytoplasm, cullin-RING ubiquitin ligase complex, Cul2-RING ubiquitin ligase complex
REACTOME DATABASE ANNOTATIONS   Click to Expand...
Reactome Pathways: FBXL7 down-regulates AURKA during mitotic entry and in early mitosis, Nuclear events mediated by NFE2L2, Gap-filling DNA repair synthesis and ligation in TC-NER, Mitotic G2-G2/M phases, Adaptive Immune System, Dual incision in TC-NER, Dual Incision in GG-NER, S Phase, Gene expression (Transcription), Signaling by WNT, Class I MHC mediated antigen processing & presentation, Recognition of DNA damage by PCNA-containing replication complex, Antigen processing: Ubiquitination & Proteasome degradation, Cellular responses to stimuli, Regulation of RUNX2 expression and activity, Hedgehog 'on' state, Orc1 removal from chromatin, KEAP1-NFE2L2 pathway, Cellular response to hypoxia, Cell Cycle, Mitotic, Synthesis of DNA, GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2, Cellular response to chemical stress, G2/M Transition, Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha, Neddylation, Post-translational protein modification, Degradation of DVL, DNA Replication, Cell Cycle, Signal Transduction, Transcriptional regulation by RUNX2, Immune System, DNA Repair, TCF dependent signaling in response to WNT, DNA Damage Bypass, Cellular responses to stress, Signaling by Hedgehog, RNA Polymerase II Transcription, Transcription-Coupled Nucleotide Excision Repair (TC-NER), Generic Transcription Pathway, Degradation of beta-catenin by the destruction complex, Formation of TC-NER Pre-Incision Complex, Switching of origins to a post-replicative state, DNA Damage Recognition in GG-NER, Formation of Incision Complex in GG-NER, Nucleotide Excision Repair, Global Genome Nucleotide Excision Repair (GG-NER), Metabolism of proteins

Orthologs