PANTHER Gene Information   
Gene Symbol(s): rpt-2
Organism: Caenorhabditis elegans
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Gene Name: Probable 26S proteasome regulatory subunit 4
Gene ID: WBGene00004502
Protein ID: O16368
Persistent Id: PTN000553302
Alternate Ids:
CCD64135(EMBL-CDS) FO080494(EMBL)
F29G9.5(Ensembl_TRS) PRS4(Synonym)
F29G9.5(Ensembl_PRO) rpt-2(Symbol)
NM_072157(refSeq) PRS4_CAEEL(UniProtKB-ID)
WBGene00004502(WormBase) 178988(GeneID)
F29G9(WormBase_TRS) CE09799(WormBase_PRO)
WBGene00004502(Ensembl) 3122624(GI)
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PANTHER Classification
PANTHER Family: 26S PROTEASOME REGULATORY SUBUNIT (PTHR23073)
PANTHER Subfamily: 26S PROTEASOME REGULATORY SUBUNIT 4 (PTHR23073:SF24)  
PANTHER GO-slim Molecular Function: ATP-dependent activity
PANTHER GO-slim Biological Process: proteasome-mediated ubiquitin-dependent protein catabolic process
PANTHER GO-slim Cellular Component: proteasome regulatory particle
PANTHER protein class: protease
Pathway Categories: Ubiquitin proteasome pathway
   26S proteasome
GENE ONTOLOGY DATABASE ANNOTATIONS      Click to Expand...
GO MF Complete: ATP hydrolysis activity, ATP binding, ubiquitin protein ligase binding, proteasome-activating activity
GO BP Complete: negative regulation of gene expression, proteasome-mediated ubiquitin-dependent protein catabolic process, positive regulation of proteasomal protein catabolic process
GO CC Complete: nucleus, proteasome regulatory particle, base subcomplex, cytoplasm, proteasome complex
REACTOME DATABASE ANNOTATIONS   Click to Expand...
Reactome Pathways: FBXL7 down-regulates AURKA during mitotic entry and in early mitosis, MAPK6/MAPK4 signaling, Intracellular signaling by second messengers, Cyclin E associated events during G1/S transition , p53-Dependent G1 DNA Damage Response, G1/S Transition, Ubiquitin Mediated Degradation of Phosphorylated Cdc25A, Nuclear events mediated by NFE2L2, Mitotic G2-G2/M phases, Adaptive Immune System, Metabolism of amino acids and derivatives, S Phase, Signaling by WNT, Gene expression (Transcription), Class I MHC mediated antigen processing & presentation, Antigen processing: Ubiquitination & Proteasome degradation, Cellular responses to stimuli, PTEN Regulation, Regulation of RUNX2 expression and activity, PIP3 activates AKT signaling, SCF(Skp2)-mediated degradation of p27/p21, Hedgehog 'on' state, Orc1 removal from chromatin, KEAP1-NFE2L2 pathway, Cellular response to hypoxia, Ubiquitin-dependent degradation of Cyclin D, Transport of small molecules, Cell Cycle, Mitotic, Synthesis of DNA, ABC-family proteins mediated transport, Metabolism, GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2, Cellular response to chemical stress, G2/M Transition, Mitotic G1 phase and G1/S transition, Neddylation, Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha, Metabolism of polyamines, Transcriptional regulation by RUNX3, Post-translational protein modification, Degradation of DVL, DNA Replication, Cell Cycle, Signal Transduction, PCP/CE pathway, Regulation of PTEN stability and activity, UCH proteinases, Autodegradation of the E3 ubiquitin ligase COP1, Cell Cycle Checkpoints, Stabilization of p53, Ub-specific processing proteases, Asymmetric localization of PCP proteins, Asparagine N-linked glycosylation, p53-Dependent G1/S DNA damage checkpoint, Immune System, Transcriptional regulation by RUNX2, Beta-catenin independent WNT signaling, TCF dependent signaling in response to WNT, Regulation of ornithine decarboxylase (ODC), G1/S DNA Damage Checkpoints, Cellular responses to stress, MAPK family signaling cascades, Signaling by Hedgehog, Deubiquitination, RNA Polymerase II Transcription, Regulation of RUNX3 expression and activity, p53-Independent G1/S DNA damage checkpoint, Cyclin A:Cdk2-associated events at S phase entry, CDK-mediated phosphorylation and removal of Cdc6, p53-Independent DNA Damage Response, N-glycan trimming in the ER and Calnexin/Calreticulin cycle, Generic Transcription Pathway, Degradation of beta-catenin by the destruction complex, Cross-presentation of soluble exogenous antigens (endosomes), Switching of origins to a post-replicative state, Metabolism of proteins, Antigen processing-Cross presentation

Orthologs