PANTHER Gene Information   
Gene Symbol(s): wu:fb05d04
Organism: Danio rerio
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Gene Name: Proteasome (Prosome, macropain) 26S subunit, ATPase, 1a
Gene ID: ZDB-GENE-030131-8730
Protein ID: Q7ZWD1
Persistent Id: PTN000553295
Alternate Ids:
Q7ZWD1(Synonym) 82241466(GI)
AAH49471(EMBL-CDS) BC049471(EMBL)
ZDB-GENE-030131-8730(ZFIN) NM_200033(refSeq)
Q7ZWD1_DANRE(UniProtKB-ID) 336786(GeneID)
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PANTHER Classification
PANTHER Family: 26S PROTEASOME REGULATORY SUBUNIT (PTHR23073)
PANTHER Subfamily: 26S PROTEASOME REGULATORY SUBUNIT 4 (PTHR23073:SF24)  
PANTHER GO-slim Molecular Function: ATP-dependent activity
PANTHER GO-slim Biological Process: proteasome-mediated ubiquitin-dependent protein catabolic process
PANTHER GO-slim Cellular Component: proteasome regulatory particle
PANTHER protein class: protease
Pathway Categories: Ubiquitin proteasome pathway
   26S proteasome
GENE ONTOLOGY DATABASE ANNOTATIONS      Click to Expand...
GO MF Complete: nucleotide binding, ATP hydrolysis activity, ATP binding, proteasome-activating activity
GO BP Complete: proteasome-mediated ubiquitin-dependent protein catabolic process, anatomical structure morphogenesis
GO CC Complete: nucleus, proteasome regulatory particle, base subcomplex, proteasome complex
REACTOME DATABASE ANNOTATIONS   Click to Expand...
Reactome Pathways: Adaptive Immune System, RNA Polymerase II Transcription, Mitotic G1 phase and G1/S transition, Assembly of the pre-replicative complex, GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2, Cellular response to chemical stress, Intracellular signaling by second messengers, Neddylation, Synthesis of DNA, Antigen processing-Cross presentation, Degradation of GLI1 by the proteasome, Metabolism of polyamines, Cross-presentation of soluble exogenous antigens (endosomes), Transport of small molecules, AUF1 (hnRNP D0) binds and destabilizes mRNA, Antigen processing: Ubiquitination & Proteasome degradation, Class I MHC mediated antigen processing & presentation, PTEN Regulation, Hedgehog 'on' state, FBXL7 down-regulates AURKA during mitotic entry and in early mitosis, Nuclear events mediated by NFE2L2, Generic Transcription Pathway, G2/M Checkpoints, Downstream signaling events of B Cell Receptor (BCR), Metabolism, p53-Dependent G1 DNA Damage Response, DNA Replication Pre-Initiation, N-glycan trimming in the ER and Calnexin/Calreticulin cycle, Mitotic G2-G2/M phases, Cellular responses to stress, ABC-family proteins mediated transport, S Phase, Regulation of RUNX3 expression and activity, Cell Cycle Checkpoints, DNA Replication, Regulation of RUNX2 expression and activity, SCF(Skp2)-mediated degradation of p27/p21, Hedgehog 'off' state, TCF dependent signaling in response to WNT, RUNX1 regulates transcription of genes involved in differentiation of HSCs, GLI3 is processed to GLI3R by the proteasome, UCH proteinases, Cell Cycle, Mitotic, G2/M Transition, Autodegradation of the E3 ubiquitin ligase COP1, Cyclin A:Cdk2-associated events at S phase entry, CDK-mediated phosphorylation and removal of Cdc6, Ub-specific processing proteases, G1/S DNA Damage Checkpoints, Beta-catenin independent WNT signaling, Metabolism of proteins, Regulation of PTEN stability and activity, Signal Transduction, Transcriptional regulation by RUNX3, Cell Cycle, Asymmetric localization of PCP proteins, Post-translational protein modification, Asparagine N-linked glycosylation, Transcriptional regulation by RUNX2, Immune System, Deubiquitination, p53-Dependent G1/S DNA damage checkpoint, Signaling by the B Cell Receptor (BCR), Stabilization of p53, Ubiquitin-dependent degradation of Cyclin D, MAPK family signaling cascades, PIP3 activates AKT signaling, Cyclin E associated events during G1/S transition , Cellular responses to stimuli, Metabolism of RNA, KEAP1-NFE2L2 pathway, G1/S Transition, Signaling by Hedgehog, Regulation of ornithine decarboxylase (ODC), The role of GTSE1 in G2/M progression after G2 checkpoint, PCP/CE pathway, Metabolism of amino acids and derivatives, Signaling by WNT, Gene expression (Transcription), Activation of NF-kappaB in B cells, Transcriptional regulation by RUNX1, Hedgehog ligand biogenesis, Degradation of AXIN, Degradation of DVL, Switching of origins to a post-replicative state, Regulation of mRNA stability by proteins that bind AU-rich elements, MAPK6/MAPK4 signaling

Orthologs