PANTHER Gene Information   
Gene Symbol(s): PSMC1
Organism: Sus scrofa
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Gene Name: 26S protease regulatory subunit 4
Gene ID: ENSSSCG00000002433.4
Protein ID: F2Z5J1
Persistent Id: PTN001497259
Alternate Ids:
NP_001231080(refSeq) ENSSSCT00000002703(Ensembl_TRS)
DQIR01153240(EMBL) 346421411(GI)
F2Z5J1(Synonym) HDB08717(EMBL-CDS)
ENSSSCG00000002433(Ensembl) F2Z5J1_PIG(UniProtKB-ID)
ENSSSCP00000002634(Ensembl_PRO) 100155274(GeneID)
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PANTHER Classification
PANTHER Family: 26S PROTEASOME REGULATORY SUBUNIT (PTHR23073)
PANTHER Subfamily: 26S PROTEASOME REGULATORY SUBUNIT 4 (PTHR23073:SF24)  
PANTHER GO-slim Molecular Function: ATP-dependent activity
PANTHER GO-slim Biological Process: proteasome-mediated ubiquitin-dependent protein catabolic process
PANTHER GO-slim Cellular Component: proteasome regulatory particle
PANTHER protein class: protease
Pathway Categories: Ubiquitin proteasome pathway
   26S proteasome
GENE ONTOLOGY DATABASE ANNOTATIONS      Click to Expand...
GO MF Complete: ATP hydrolysis activity, ATP binding, peptidase activity, proteasome-activating activity
GO BP Complete: proteasome-mediated ubiquitin-dependent protein catabolic process, positive regulation of proteasomal protein catabolic process
GO CC Complete: proteasome regulatory particle, base subcomplex, cytosol, nucleoplasm
REACTOME DATABASE ANNOTATIONS   Click to Expand...
Reactome Pathways: TNFR2 non-canonical NF-kB pathway, TCR signaling, Ub-specific processing proteases, Metabolism of proteins, Metabolism of amino acids and derivatives, Gene expression (Transcription), DNA Replication Pre-Initiation, Degradation of DVL, S Phase, Degradation of AXIN, PCP/CE pathway, MAPK1/MAPK3 signaling, Innate Immune System, Autodegradation of Cdh1 by Cdh1:APC/C, Ubiquitin-dependent degradation of Cyclin D, G2/M Checkpoints, Downstream signaling events of B Cell Receptor (BCR), SCF(Skp2)-mediated degradation of p27/p21, Synthesis of DNA, Orc1 removal from chromatin, TCF dependent signaling in response to WNT, Hedgehog 'off' state, Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins, GLI3 is processed to GLI3R by the proteasome, Regulation of RAS by GAPs, Degradation of GLI1 by the proteasome, Cell Cycle, Antigen processing: Ubiquitination & Proteasome degradation, Class I MHC mediated antigen processing & presentation, Deubiquitination, ABC-family proteins mediated transport, Transport of small molecules, Metabolism, Metabolism of polyamines, Mitotic G2-G2/M phases, Cellular response to chemical stress, Regulation of mitotic cell cycle, GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2, Mitotic G1 phase and G1/S transition, Downstream TCR signaling, Cytokine Signaling in Immune system, Adaptive Immune System, Interleukin-1 family signaling, Signaling by WNT, Intracellular signaling by second messengers, Cell Cycle Checkpoints, MAPK6/MAPK4 signaling, Hedgehog 'on' state, APC/C-mediated degradation of cell cycle proteins, Neddylation, FCERI mediated NF-kB activation, p53-Dependent G1/S DNA damage checkpoint, G1/S DNA Damage Checkpoints, p53-Independent G1/S DNA damage checkpoint, Nuclear events mediated by NFE2L2, APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint, Mitotic Anaphase, NIK-->noncanonical NF-kB signaling, FBXL7 down-regulates AURKA during mitotic entry and in early mitosis, Immune System, M Phase, Interleukin-1 signaling, p53-Independent DNA Damage Response, Metabolism of RNA, The role of GTSE1 in G2/M progression after G2 checkpoint, RAF/MAP kinase cascade, Autodegradation of the E3 ubiquitin ligase COP1, PIP3 activates AKT signaling, Separation of Sister Chromatids, Signaling by the B Cell Receptor (BCR), Switching of origins to a post-replicative state, Signal Transduction, G1/S Transition, Post-translational protein modification, p53-Dependent G1 DNA Damage Response, Fc epsilon receptor (FCERI) signaling, Signaling by Interleukins, Ubiquitin Mediated Degradation of Phosphorylated Cdc25A, Signaling by Hedgehog, Cyclin E associated events during G1/S transition , Regulation of mRNA stability by proteins that bind AU-rich elements, Cellular response to hypoxia, UCH proteinases, Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha, RUNX1 regulates transcription of genes involved in differentiation of HSCs, Transcriptional regulation by RUNX3, Assembly of the pre-replicative complex, AUF1 (hnRNP D0) binds and destabilizes mRNA, Asymmetric localization of PCP proteins, Cell Cycle, Mitotic, G2/M Transition, MAPK family signaling cascades, Cellular responses to stress, PTEN Regulation, Mitotic Metaphase and Anaphase, APC/C:Cdc20 mediated degradation of Securin, Beta-catenin independent WNT signaling, Regulation of RUNX2 expression and activity, Cross-presentation of soluble exogenous antigens (endosomes), Regulation of RUNX3 expression and activity, Activation of NF-kappaB in B cells, DNA Replication, APC/C:Cdc20 mediated degradation of mitotic proteins, Stabilization of p53, Transcriptional regulation by RUNX1, Dectin-1 mediated noncanonical NF-kB signaling, Cdc20:Phospho-APC/C mediated degradation of Cyclin A, CLEC7A (Dectin-1) signaling, RNA Polymerase II Transcription, Antigen processing-Cross presentation, Regulation of ornithine decarboxylase (ODC), C-type lectin receptors (CLRs), N-glycan trimming in the ER and Calnexin/Calreticulin cycle, Degradation of beta-catenin by the destruction complex, Hedgehog ligand biogenesis, CDK-mediated phosphorylation and removal of Cdc6, Generic Transcription Pathway, Regulation of PTEN stability and activity, Cyclin A:Cdk2-associated events at S phase entry, KEAP1-NFE2L2 pathway, Asparagine N-linked glycosylation, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, Transcriptional regulation by RUNX2, Cellular responses to stimuli

Orthologs