PANTHER Gene Information

Gene Symbol(s):

sli-1

Organism:

Caenorhabditis elegans

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Gene Name:

E3 ubiquitin-protein ligase CBL

Gene ID:

WBGene00004829

Protein ID:

Q19019

Persistent Id:

PTN000544084

Alternate Ids:

CAA61507(EMBL-CDS)	WBGene00004829(Ensembl)
Q19019_CAEEL(UniProtKB-ID)	X89223(EMBL)
WBGene00004829(WormBase)	CE25058(WormBase_PRO)
180419(GeneID)	NM_075744(refSeq)
373218716(GI)	M02A10.3a(WormBase_TRS)
Q19019(Synonym)
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PANTHER Classification

PANTHER Family:	CBL (PTHR23007)
PANTHER Subfamily:	E3 UBIQUITIN-PROTEIN LIGASE CBL (PTHR23007:SF11)
PANTHER GO-slim Molecular Function:	ubiquitin protein ligase activity SH3 domain binding
PANTHER GO-slim Biological Process:	signal transduction
PANTHER GO-slim Cellular Component:	membrane raft plasma membrane
PANTHER protein class:	ligase

Pathway Categories:

EGF receptor signaling pathway

Cas-Br-M (murine) ecotropic retroviral transforming oncogene

GENE ONTOLOGY DATABASE ANNOTATIONS

Click to Expand...

GO MF Complete:	phosphotyrosine residue binding, ubiquitin-protein transferase activity, ubiquitin protein ligase activity, protein binding, metal ion binding, calcium ion binding, transferase activity, receptor tyrosine kinase binding
GO BP Complete:	negative regulation of vulval development, regulation of signaling, signal transduction, cell surface receptor signaling pathway, negative regulation of epidermal growth factor receptor signaling pathway, protein ubiquitination
GO CC Complete:	membrane raft, plasma membrane

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Signaling by Non-Receptor Tyrosine Kinases, Signal Transduction, EGFR downregulation, Vesicle-mediated transport, Membrane Trafficking, Adaptive Immune System, Interleukin-3, Interleukin-5 and GM-CSF signaling, PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1, Signaling by Receptor Tyrosine Kinases, Class I MHC mediated antigen processing & presentation, Immune System, Antigen processing: Ubiquitination & Proteasome degradation, Signaling by SCF-KIT, Signaling by TGFB family members, Signaling by MET, Regulation of KIT signaling, Signaling by PTK6, TGF-beta receptor signaling activates SMADs, Clathrin-mediated endocytosis, Negative regulation of MET activity, Cargo recognition for clathrin-mediated endocytosis, Cytokine Signaling in Immune system, Signaling by Interleukins, Signaling by EGFR, Signaling by TGF-beta Receptor Complex, Regulation of signaling by CBL

Orthologs

ID	Organism	Type
HUMAN\|HGNC=1542\|UniProtKB=Q13191	Homo sapiens	O
PANTR\|Ensembl=ENSPTRG00000015184.6\|UniProtKB=H2QN18	Pan troglodytes	O
GORGO\|Ensembl=ENSGGOG00000022475.2\|UniProtKB=G3RS61	Gorilla gorilla gorilla	O
MACMU\|Ensembl=ENSMMUG00000007565.4\|UniProtKB=A0A5F8ACF3	Macaca mulatta	O
MOUSE\|MGI=MGI=2146430\|UniProtKB=Q3TTA7	Mus musculus	O
RAT\|RGD=620535\|UniProtKB=Q8K4S7	Rattus norvegicus	O
BOVIN\|Ensembl=ENSBTAG00000013057.6\|UniProtKB=A0A3Q1LUB2	Bos taurus	O
PIG\|Ensembl=ENSSSCG00000022486.4\|UniProtKB=A0A5K1V2H7	Sus scrofa	O
HORSE\|Ensembl=ENSECAG00000014300.4\|UniProtKB=A0A3Q2H9F6	Equus caballus	O
FELCA\|Ensembl=ENSFCAG00000004555.6\|UniProtKB=M3W2E6	Felis catus	O
CANLF\|Ensembl=ENSCAFG00845022767.1\|UniProtKB=A0A8I3PCV8	Canis lupus familiaris	O
MONDO\|Ensembl=ENSMODG00000001816.5\|UniProtKB=F6T5M5	Monodelphis domestica	O
ORNAN\|Ensembl=ENSOANG00000007499.4\|UniProtKB=F6QKN5	Ornithorhynchus anatinus	O
CHICK\|Ensembl=ENSGALG00010005166.1\|UniProtKB=F1NL77	Gallus gallus	O
ANOCA\|Ensembl=ENSACAG00000006453.4\|UniProtKB=A0A803T3M5	Anolis carolinensis	O
XENLA\|Gene=cblb-b\|UniProtKB=Q6NRE7	Xenopus laevis	O
XENLA\|Gene=cblb-a\|UniProtKB=Q6GQL0	Xenopus laevis	O
ORYLA\|Ensembl=ENSORLG00000029594.1\|UniProtKB=A0A3B3H796	Oryzias latipes	O
DANRE\|ZFIN=ZDB-GENE-030616-417\|UniProtKB=F1Q742	Danio rerio	O
LEPOC\|Ensembl=ENSLOCG00000005184.1\|UniProtKB=W5MCY6	lepisosteus oculatus	O
HUMAN\|HGNC=15961\|UniProtKB=Q9ULV8	Homo sapiens	O
PANTR\|Ensembl=ENSPTRG00000011123.5\|UniProtKB=A0A2I3T7P1	Pan troglodytes	O
GORGO\|Ensembl=ENSGGOG00000025562.2\|UniProtKB=G3S653	Gorilla gorilla gorilla	O
MACMU\|Ensembl=ENSMMUG00000049451.1\|UniProtKB=F7FKP6	Macaca mulatta	O
MOUSE\|MGI=MGI=1931457\|UniProtKB=Q80XL1	Mus musculus	O
RAT\|RGD=1307651\|UniProtKB=G3V8H4	Rattus norvegicus	O
BOVIN\|Ensembl=ENSBTAG00000009494.5\|UniProtKB=A6QPZ5	Bos taurus	O
PIG\|Ensembl=ENSSSCG00000003083.4\|UniProtKB=A0A287A822	Sus scrofa	O
HORSE\|Ensembl=ENSECAG00000046603.1\|UniProtKB=A0A9L0TFS6	Equus caballus	O
FELCA\|Ensembl=ENSFCAG00000004785.6\|UniProtKB=A0A2I2U115	Felis catus	O
CANLF\|Ensembl=ENSCAFG00845006988.1\|UniProtKB=A0A8I3N747	Canis lupus familiaris	O
ORNAN\|Ensembl=ENSOANG00000046609.1\|UniProtKB=A0A6I8NX17	Ornithorhynchus anatinus	O
HUMAN\|HGNC=1541\|UniProtKB=P22681	Homo sapiens	LDO
PANTR\|Ensembl=ENSPTRG00000004378.4\|UniProtKB=H2Q4Y2	Pan troglodytes	LDO
GORGO\|Ensembl=ENSGGOG00000003804.3\|UniProtKB=G3RNI2	Gorilla gorilla gorilla	LDO
MACMU\|Ensembl=ENSMMUG00000004761.4\|UniProtKB=A0A1D5RFE7	Macaca mulatta	LDO
MOUSE\|MGI=MGI=88279\|UniProtKB=P22682	Mus musculus	LDO
RAT\|RGD=1561386\|UniProtKB=A0A8I6G3R2	Rattus norvegicus	LDO
BOVIN\|Ensembl=ENSBTAG00000006817.6\|UniProtKB=A0A3Q1LN00	Bos taurus	LDO
PIG\|Ensembl=ENSSSCG00000015115.5\|UniProtKB=A0A286ZQE1	Sus scrofa	LDO
HORSE\|Ensembl=ENSECAG00000003448.3\|UniProtKB=A0A9L0RL05	Equus caballus	LDO
FELCA\|Ensembl=ENSFCAG00000004737.6\|UniProtKB=M3WT44	Felis catus	LDO
CANLF\|Ensembl=ENSCAFG00845000222.1\|UniProtKB=A0A8I3MBU4	Canis lupus familiaris	LDO
MONDO\|Ensembl=ENSMODG00000013232.4\|UniProtKB=F7ECX4	Monodelphis domestica	LDO
ORNAN\|Ensembl=ENSOANG00000039233.1\|UniProtKB=A0A6I8NXH0	Ornithorhynchus anatinus	LDO
CHICK\|Ensembl=ENSGALG00010024138.1\|UniProtKB=A0A8V0ZY53	Gallus gallus	LDO
ANOCA\|Ensembl=ENSACAG00000002124.3\|UniProtKB=H9G617	Anolis carolinensis	LDO
XENLA\|Gene=LOC121395620\|UniProtKB=A0A8J1LA46	Xenopus laevis	O
XENLA\|Gene=cblc.S\|UniProtKB=A0A1L8FGY8	Xenopus laevis	O
XENTR\|Gene=cblc\|UniProtKB=A0A8J0QSR3	Xenopus tropicalis	O
XENLA\|Gene=cbl.S\|UniProtKB=A0A310TNL8	Xenopus laevis	O
XENLA\|Gene=cbl.L\|UniProtKB=A0A1L8FLE4	Xenopus laevis	LDO
ORYLA\|Ensembl=ENSORLG00000013615.2\|UniProtKB=H2MER5	Oryzias latipes	O
DANRE\|Gene=cblc\|UniProtKB=A0A8M9PD63	Danio rerio	O
LEPOC\|Ensembl=ENSLOCG00000004326.1\|UniProtKB=W5M9V8	lepisosteus oculatus	O
ORYLA\|Ensembl=ENSORLG00000014525.2\|UniProtKB=H2MHT7	Oryzias latipes	O
ORYLA\|Ensembl=ENSORLG00000007611.2\|UniProtKB=H2LTW9	Oryzias latipes	LDO
DANRE\|ZFIN=ZDB-GENE-041114-207\|UniProtKB=Q5U376	Danio rerio	LDO
LEPOC\|Ensembl=ENSLOCG00000003343.1\|UniProtKB=W5M6I7	lepisosteus oculatus	LDO
CIOIN\|Ensembl=ENSCING00000002655.3\|UniProtKB=F6YDP2	Ciona intestinalis	LDO
BRAFL\|Gene=LOC118411907\|UniProtKB=A0A9J7KTH8	Branchiostoma floridae	LDO
STRPU\|EnsemblGenome=LOC100890602\|UniProtKB=A0A7M7NDP2	Strongylocentrotus purpuratus	LDO
CAEBR\|Gene_ORFName=CBG08124\|UniProtKB=A8X5V5	Caenorhabditis briggsae	LDO
PRIPA\|EnsemblGenome=WBGene00113114\|UniProtKB=A0A2A6B2B8	Pristionchus pacificus	LDO
DROME\|FlyBase=FBgn0020224\|UniProtKB=Q9VSK2	Drosophila melanogaster	LDO
ANOGA\|EnsemblGenome=AGAP005449\|UniProtKB=A0A1S4GP81	Anopheles gambiae	LDO
TRICA\|EnsemblGenome=TC032308\|UniProtKB=A0A139WL83	Tribolium castaneum	LDO
IXOSC\|EnsemblGenome=ISCW019991\|UniProtKB=B7PWV3	Ixodes scapularis	LDO
TRIAD\|EnsemblGenome=TriadG23727\|UniProtKB=B3RTT8	Trichoplax adhaerens	LDO
MONBE\|EnsemblGenome=MONBRDRAFT_36983\|UniProtKB=A9UYU0	Monosiga brevicollis	LDO
TRIV3\|Gene_ORFName=TVAG_054550\|UniProtKB=A2EYD0	Trichomonas vaginalis	LDO
PLAF7\|EnsemblGenome=PF3D7_1208800\|UniProtKB=Q8I5W0	Plasmodium falciparum	LDO