PANTHER Gene Information

Gene Symbol(s):

CBLB

Organism:

Canis lupus familiaris

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Gene Name:

E3 ubiquitin-protein ligase CBL

Gene ID:

ENSCAFG00845022767.1

Protein ID:

A0A8I3PCV8

Persistent Id:

PTN000544027

Alternate Ids:

545552701(GI)	XP_005639497(refSeq)
ENSCAFT00845040246(Ensembl_TRS)	A0A8I3PCV8(Synonym)
ENSCAFG00845022767(Ensembl)	ENSCAFP00845031528(Ensembl_PRO)
A0A8I3PCV8_CANLF(UniProtKB-ID)	487965(GeneID)
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PANTHER Classification

PANTHER Family:	CBL (PTHR23007)
PANTHER Subfamily:	E3 UBIQUITIN-PROTEIN LIGASE CBL-B (PTHR23007:SF3)
PANTHER GO-slim Molecular Function:	ubiquitin protein ligase activity receptor tyrosine kinase binding SH3 domain binding
PANTHER GO-slim Biological Process:	regulation of epidermal growth factor receptor signaling pathway negative regulation of protein kinase activity signal transduction negative regulation of signal transduction regulation of peptidyl-tyrosine phosphorylation
PANTHER GO-slim Cellular Component:	membrane raft plasma membrane
PANTHER protein class:	ligase

Pathway Categories:

EGF receptor signaling pathway

Cas-Br-M (murine) ecotropic retroviral transforming oncogene

GENE ONTOLOGY DATABASE ANNOTATIONS

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GO MF Complete:	phosphotyrosine residue binding, ubiquitin-protein transferase activity, ubiquitin protein ligase activity, calcium ion binding, receptor tyrosine kinase binding
GO BP Complete:	signal transduction, protein catabolic process, positive regulation of protein catabolic process, negative regulation of epidermal growth factor receptor signaling pathway, T cell anergy, immune response, negative regulation of T cell receptor signaling pathway, positive regulation of T cell anergy, CD4-positive, alpha-beta T cell proliferation, regulation of postsynaptic neurotransmitter receptor internalization, positive regulation of protein ubiquitination, regulation protein catabolic process at postsynapse, regulation of platelet-derived growth factor receptor-alpha signaling pathway, negative regulation of CD4-positive, alpha-beta T cell proliferation, intracellular signal transduction, T cell receptor signaling pathway, protein ubiquitination
GO CC Complete:	postsynapse, membrane raft, cytosol, glutamatergic synapse, plasma membrane, nucleoplasm

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Adaptive Immune System, Immune System, Class I MHC mediated antigen processing & presentation, Antigen processing: Ubiquitination & Proteasome degradation

Orthologs

ID	Organism	Type
HUMAN\|HGNC=1542\|UniProtKB=Q13191	Homo sapiens	LDO
PANTR\|Ensembl=ENSPTRG00000015184.6\|UniProtKB=H2QN18	Pan troglodytes	LDO
GORGO\|Ensembl=ENSGGOG00000022475.2\|UniProtKB=G3RS61	Gorilla gorilla gorilla	LDO
MACMU\|Ensembl=ENSMMUG00000007565.4\|UniProtKB=A0A5F8ACF3	Macaca mulatta	LDO
MOUSE\|MGI=MGI=2146430\|UniProtKB=Q3TTA7	Mus musculus	LDO
RAT\|RGD=620535\|UniProtKB=Q8K4S7	Rattus norvegicus	LDO
BOVIN\|Ensembl=ENSBTAG00000013057.6\|UniProtKB=A0A3Q1LUB2	Bos taurus	LDO
PIG\|Ensembl=ENSSSCG00000022486.4\|UniProtKB=A0A5K1V2H7	Sus scrofa	LDO
HORSE\|Ensembl=ENSECAG00000014300.4\|UniProtKB=A0A3Q2H9F6	Equus caballus	LDO
FELCA\|Ensembl=ENSFCAG00000004555.6\|UniProtKB=M3W2E6	Felis catus	LDO
MONDO\|Ensembl=ENSMODG00000001816.5\|UniProtKB=F6T5M5	Monodelphis domestica	LDO
ORNAN\|Ensembl=ENSOANG00000007499.4\|UniProtKB=F6QKN5	Ornithorhynchus anatinus	LDO
CHICK\|Ensembl=ENSGALG00010005166.1\|UniProtKB=F1NL77	Gallus gallus	LDO
ANOCA\|Ensembl=ENSACAG00000006453.4\|UniProtKB=A0A803T3M5	Anolis carolinensis	LDO
XENLA\|Gene=cblb-b\|UniProtKB=Q6NRE7	Xenopus laevis	O
XENLA\|Gene=cblb-a\|UniProtKB=Q6GQL0	Xenopus laevis	LDO
ORYLA\|Ensembl=ENSORLG00000029594.1\|UniProtKB=A0A3B3H796	Oryzias latipes	LDO
DANRE\|ZFIN=ZDB-GENE-030616-417\|UniProtKB=F1Q742	Danio rerio	LDO
LEPOC\|Ensembl=ENSLOCG00000005184.1\|UniProtKB=W5MCY6	lepisosteus oculatus	LDO
CIOIN\|Ensembl=ENSCING00000002655.3\|UniProtKB=F6YDP2	Ciona intestinalis	O
BRAFL\|Gene=LOC118411907\|UniProtKB=A0A9J7KTH8	Branchiostoma floridae	O
STRPU\|EnsemblGenome=LOC100890602\|UniProtKB=A0A7M7NDP2	Strongylocentrotus purpuratus	O
CAEEL\|WormBase=WBGene00004829\|UniProtKB=Q19019	Caenorhabditis elegans	O
CAEBR\|Gene_ORFName=CBG08124\|UniProtKB=A8X5V5	Caenorhabditis briggsae	O
PRIPA\|EnsemblGenome=WBGene00113114\|UniProtKB=A0A2A6B2B8	Pristionchus pacificus	O
DROME\|FlyBase=FBgn0020224\|UniProtKB=Q9VSK2	Drosophila melanogaster	O
ANOGA\|EnsemblGenome=AGAP005449\|UniProtKB=A0A1S4GP81	Anopheles gambiae	O
TRICA\|EnsemblGenome=TC032308\|UniProtKB=A0A139WL83	Tribolium castaneum	O
IXOSC\|EnsemblGenome=ISCW019991\|UniProtKB=B7PWV3	Ixodes scapularis	O
TRIAD\|EnsemblGenome=TriadG23727\|UniProtKB=B3RTT8	Trichoplax adhaerens	O
MONBE\|EnsemblGenome=MONBRDRAFT_36983\|UniProtKB=A9UYU0	Monosiga brevicollis	O
TRIV3\|Gene_ORFName=TVAG_054550\|UniProtKB=A2EYD0	Trichomonas vaginalis	O
PLAF7\|EnsemblGenome=PF3D7_1208800\|UniProtKB=Q8I5W0	Plasmodium falciparum	O