PANTHER Gene Information   
Gene Symbol(s): AURKA
Organism: Canis lupus familiaris
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Gene Name: Aurora kinase A
Gene ID: ENSCAFG00030025248
Protein ID: A0A8I3S724
Persistent Id: PTN001553228
Alternate Ids:
ENSCAFG00000029331(Ensembl) ENSCAFP00845040568(Ensembl_PRO)
AURKA_CANLF(UniProtKB-ID) AIK{ECO:0000250|UniProtKB:O14965}(Synonym)
2.7.11.1 {ECO:0000250|UniProtKB:O14965}(EC) A0A8C0YY51(AltAccession)
AURKA{ECO:0000250|UniProtKB:O14965}(Symbol) 2316836404(GI)
ENSCAFT00845051705(Ensembl_TRS)
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PANTHER Classification
PANTHER Family: SERINE/THREONINE-PROTEIN KINASE IAL-RELATED (PTHR24350)
PANTHER Subfamily: AURORA KINASE A (PTHR24350:SF5)  
PANTHER GO-slim Molecular Function:
PANTHER GO-slim Biological Process: regulation of cytokinesis
mitotic spindle organization
PANTHER GO-slim Cellular Component: spindle midzone
microtubule associated complex
spindle microtubule
nucleus
kinetochore
centrosome
spindle pole
PANTHER protein class: non-receptor serine/threonine protein kinase
Pathway Categories: No pathway information available
GENE ONTOLOGY DATABASE ANNOTATIONS      Click to Expand...
GO MF Complete: ATP binding, protein serine/threonine kinase activity
GO BP Complete: cell division, mitotic spindle organization, regulation of cytokinesis, mitotic centrosome separation, meiotic spindle organization, positive regulation of mitotic cell cycle
GO CC Complete: spindle pole, kinetochore, neuron projection, microtubule, nucleus, spindle microtubule, centrosome, spindle midzone, cytoplasm, centriole, cilium, chromosome passenger complex, basolateral plasma membrane
REACTOME DATABASE ANNOTATIONS   Click to Expand...
Reactome Pathways: Gene expression (Transcription), Regulation of TP53 Activity, Generic Transcription Pathway, FBXL7 down-regulates AURKA during mitotic entry and in early mitosis, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, Regulation of mitotic cell cycle, Transcriptional Regulation by TP53, APC/C-mediated degradation of cell cycle proteins, Mitotic G2-G2/M phases, Interaction between PHLDA1 and AURKA, TP53 Regulates Transcription of Cell Cycle Genes, AURKA Activation by TPX2, TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest, RNA Polymerase II Transcription, Regulation of PLK1 Activity at G2/M Transition, Regulation of TP53 Activity through Phosphorylation, G2/M Transition, Cell Cycle, Mitotic, Cell Cycle

Orthologs