PANTHER Gene Information   
Gene Symbol(s): Aurka
Organism: Rattus norvegicus
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Gene Name: Aurora kinase A
Gene ID: 628895
Protein ID: P59241
Persistent Id: PTN000682021
Alternate Ids:
AURKA_RAT(UniProtKB-ID) ratAurA {ECO:0000303|PubMed:12124350}(Synonym)
27923854(GI) 2.7.11.1 {ECO:0000250|UniProtKB:P04198}(EC)
AF537333(EMBL) AAN06823(EMBL-CDS)
628895(RGD) Aurka{ECO:0000312|RGD:628895}(Symbol)
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PANTHER Classification
PANTHER Family: SERINE/THREONINE-PROTEIN KINASE IAL-RELATED (PTHR24350)
PANTHER Subfamily: AURORA KINASE A (PTHR24350:SF5)  
PANTHER GO-slim Molecular Function:
PANTHER GO-slim Biological Process: regulation of cytokinesis
mitotic spindle organization
PANTHER GO-slim Cellular Component: spindle midzone
microtubule associated complex
spindle microtubule
nucleus
kinetochore
centrosome
spindle pole
PANTHER protein class: non-receptor serine/threonine protein kinase
Pathway Categories: No pathway information available
GENE ONTOLOGY DATABASE ANNOTATIONS      Click to Expand...
GO MF Complete: ribosomal protein S6 kinase activity, DNA-dependent protein kinase activity, ATP binding, histone H2AT120 kinase activity, AMP-activated protein kinase activity, protein heterodimerization activity, histone H3S57 kinase activity, histone H4S1 kinase activity, histone H3S28 kinase activity, histone H3T45 kinase activity, histone H2AXS139 kinase activity, molecular function activator activity, protein serine kinase activity, protein kinase binding, histone H3S10 kinase activity, histone H2BS14 kinase activity, histone H2AS1 kinase activity, protein kinase activity, eukaryotic translation initiation factor 2alpha kinase activity, protein serine/threonine kinase activity, 3-phosphoinositide-dependent protein kinase activity, ubiquitin protein ligase binding, histone H2AS121 kinase activity, histone H3T3 kinase activity, histone H2BS36 kinase activity, Rho-dependent protein serine/threonine kinase activity, histone H3T11 kinase activity, histone H3T6 kinase activity
GO BP Complete: spindle organization, positive regulation of oocyte maturation, positive regulation of translation, centrosome cycle, mitotic spindle organization, response to wounding, spindle assembly involved in female meiosis I, protein phosphorylation, meiotic spindle organization, mitotic cell cycle, cell division, centrosome localization, anterior/posterior axis specification, chromatin remodeling, meiotic cell cycle, liver regeneration, apoptotic process, regulation of cytokinesis, protein localization to centrosome, positive regulation of meiotic cell cycle process involved in oocyte maturation, mitotic centrosome separation, microtubule cytoskeleton organization, positive regulation of mitochondrial fission, cilium disassembly, positive regulation of mitotic cell cycle, negative regulation of gene expression, proteasome-mediated ubiquitin-dependent protein catabolic process, regulation of protein stability, neuron projection extension, negative regulation of apoptotic process, response to estradiol, peptidyl-serine phosphorylation, positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO CC Complete: postsynaptic density, microtubule cytoskeleton, kinetochore, axon hillock, nucleoplasm, microtubule, spindle pole centrosome, mitotic spindle, cytosol, meiotic spindle, glutamatergic synapse, ciliary basal body, spindle pole, germinal vesicle, nucleus, spindle microtubule, centrosome, spindle midzone, perinuclear region of cytoplasm, mitotic spindle pole, microtubule organizing center, centriole, pronucleus, spindle, chromosome passenger complex, basolateral plasma membrane
REACTOME DATABASE ANNOTATIONS   Click to Expand...
Reactome Pathways: Cell Cycle, Mitotic, FBXL7 down-regulates AURKA during mitotic entry and in early mitosis, Regulation of PLK1 Activity at G2/M Transition, G2/M Transition, Cell Cycle, TP53 Regulates Transcription of Cell Cycle Genes, RNA Polymerase II Transcription, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, Generic Transcription Pathway, Interaction between PHLDA1 and AURKA, Regulation of mitotic cell cycle, TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest, Transcriptional Regulation by TP53, APC/C-mediated degradation of cell cycle proteins, Regulation of TP53 Activity, Mitotic G2-G2/M phases, Gene expression (Transcription), Regulation of TP53 Activity through Phosphorylation, AURKA Activation by TPX2

Orthologs