PANTHER Gene Information   
Gene Symbol(s): NFATC1
Organism: Canis lupus familiaris
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Gene Name: Nuclear factor of activated T cells 1
Gene ID: ENSCAFG00845000073.1
Protein ID: A0A8I3MEU0
Persistent Id: PTN000283333
Alternate Ids:
ENSCAFP00845000105(Ensembl_PRO) ENSCAFG00845000073(Ensembl)
A0A8I3MEU0_CANLF(UniProtKB-ID) ENSCAFT00845000140(Ensembl_TRS)
A0A8I3MEU0(Synonym)
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PANTHER Classification
PANTHER Family: NFAT (PTHR12533)
PANTHER Subfamily: NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 1 (PTHR12533:SF5)  
PANTHER GO-slim Molecular Function: DNA-binding transcription factor activity, RNA polymerase II-specific
transcription factor binding
RNA polymerase II cis-regulatory region sequence-specific DNA binding
PANTHER GO-slim Biological Process: regulation of transcription by RNA polymerase II
calcineurin-mediated signaling
cytokine production
PANTHER GO-slim Cellular Component: transcription regulator complex
PANTHER protein class: Rel homology transcription factor
Pathway Categories: T cell activation
   Nuclear factor of activated T cells
Inflammation mediated by chemokine and cytokine signaling pathway
   Nuclear factor of activated T cells
Gonadotropin-releasing hormone receptor pathway
   NFAT
B cell activation
   Nuclear factor of activated T cells
Wnt signaling pathway
   Nuclear factor of activated T-cells
GENE ONTOLOGY DATABASE ANNOTATIONS      Click to Expand...
GO MF Complete: RNA polymerase II cis-regulatory region sequence-specific DNA binding, transcription factor binding, DNA-binding transcription factor activity, RNA polymerase II-specific
GO BP Complete: calcineurin-NFAT signaling cascade, cytokine production, positive regulation of transcription by RNA polymerase II, negative regulation of vascular associated smooth muscle cell differentiation, regulation of transcription by RNA polymerase II
GO CC Complete: transcription regulator complex, nuclear body, cytoplasm, chromatin
REACTOME DATABASE ANNOTATIONS   Click to Expand...
Reactome Pathways: Fc epsilon receptor (FCERI) signaling, Calcineurin activates NFAT, CLEC7A (Dectin-1) signaling, CLEC7A (Dectin-1) induces NFAT activation, FCERI mediated Ca+2 mobilization, Signaling by the B Cell Receptor (BCR), Adaptive Immune System, Innate Immune System, Signal Transduction, Immune System, Signaling by WNT, Beta-catenin independent WNT signaling, Downstream signaling events of B Cell Receptor (BCR), Ca2+ pathway, C-type lectin receptors (CLRs)

Orthologs