PANTHER Gene Information   
Gene Symbol(s): Nfatc1
Organism: Rattus norvegicus
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Gene Name: Nuclear factor of activated T-cells 1
Gene ID: 2319357
Protein ID: D3ZE20
Persistent Id: PTN001394574
Alternate Ids:
ENSRNOT00000058382(Ensembl_TRS) ENSRNOP00000055183(Ensembl_PRO)
D3ZE20(Synonym) ENSRNOG00000017146(Ensembl)
D3ZE20_RAT(UniProtKB-ID) 2319357(RGD)
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PANTHER Classification
PANTHER Family: NFAT (PTHR12533)
PANTHER Subfamily: NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 1 (PTHR12533:SF5)  
PANTHER GO-slim Molecular Function: DNA-binding transcription factor activity, RNA polymerase II-specific
transcription factor binding
RNA polymerase II cis-regulatory region sequence-specific DNA binding
PANTHER GO-slim Biological Process: regulation of transcription by RNA polymerase II
calcineurin-mediated signaling
cytokine production
PANTHER GO-slim Cellular Component: transcription regulator complex
PANTHER protein class: Rel homology transcription factor
Pathway Categories: T cell activation
   Nuclear factor of activated T cells
Inflammation mediated by chemokine and cytokine signaling pathway
   Nuclear factor of activated T cells
Gonadotropin-releasing hormone receptor pathway
   NFAT
B cell activation
   Nuclear factor of activated T cells
Wnt signaling pathway
   Nuclear factor of activated T-cells

GO MF Complete: RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, sequence-specific DNA binding, DNA-binding transcription repressor activity, RNA polymerase II-specific, chromatin binding, transcription factor binding, DNA-binding transcription factor activity, RNA polymerase II-specific, transcription coactivator binding, nucleic acid binding, DNA binding, protein binding, mitogen-activated protein kinase p38 binding, RNA polymerase II-specific DNA-binding transcription factor binding, sequence-specific double-stranded DNA binding, DNA-binding transcription factor binding
GO BP Complete: transition between fast and slow fiber, heart valve development, transcription by RNA polymerase II, endocardial cushion development, aortic valve development, pulmonary valve development, skeletal muscle adaptation, positive regulation of transcription by RNA polymerase II, heart valve morphogenesis, regulation of hair cycle, negative regulation of osteoblast differentiation, negative regulation of transcription by RNA polymerase II, negative regulation of keratinocyte proliferation, heart development, wound healing, B-1a B cell differentiation, cellular response to calcium ion, positive regulation of DNA-templated transcription, G1/S transition of mitotic cell cycle, calcium ion transport, stem cell proliferation, lymphangiogenesis, cellular response to tumor necrosis factor, negative regulation of vascular associated smooth muscle cell differentiation, positive regulation of DNA biosynthetic process, intracellular signal transduction, calcineurin-NFAT signaling cascade, mononuclear cell differentiation, response to muscle activity, keratinocyte proliferation, aortic valve morphogenesis, semi-lunar valve development, heart trabecula morphogenesis, pulmonary valve morphogenesis, ventricular septum morphogenesis, regulation of transcription by RNA polymerase II, branching involved in lymph vessel morphogenesis, osteoclast differentiation, cellular response to transforming growth factor beta stimulus, negative regulation of stem cell proliferation, positive regulation of gene expression, epithelial to mesenchymal transition, gene expression, cytokine production
GO CC Complete: nucleus, transcription regulator complex, nuclear body, perinuclear region of cytoplasm, sarcoplasm, cytoplasm, chromatin, nucleoplasm
Reactome Pathways: FCERI mediated Ca+2 mobilization, Ca2+ pathway, CLEC7A (Dectin-1) induces NFAT activation, Fc epsilon receptor (FCERI) signaling, Calcineurin activates NFAT, Signal Transduction, Beta-catenin independent WNT signaling, CLEC7A (Dectin-1) signaling, Immune System, C-type lectin receptors (CLRs), Signaling by WNT, Innate Immune System, Signaling by the B Cell Receptor (BCR), Adaptive Immune System, Downstream signaling events of B Cell Receptor (BCR)