PANTHER Gene Information

Gene Symbol(s):

SLC4A1

Organism:

Canis lupus familiaris

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Gene Name:

Anion exchange protein

Gene ID:

ENSCAFG00845008600.1

Protein ID:

Q2Z1P8

Persistent Id:

PTN000155432

Alternate Ids:

AB242566(EMBL)	Q2Z1P8(Synonym)
Q2Z1P8_CANLF(UniProtKB-ID)	XP_005624402(refSeq)
ENSCAFG00845008600(Ensembl)	545510204(GI)
490939(GeneID)	BAE48712(EMBL-CDS)
ENSCAFT00845015153(Ensembl_TRS)	ENSCAFP00845011764(Ensembl_PRO)
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PANTHER Classification

PANTHER Family:	ANION EXCHANGE PROTEIN (PTHR11453)
PANTHER Subfamily:	BAND 3 ANION TRANSPORT PROTEIN (PTHR11453:SF12)
PANTHER GO-slim Molecular Function:	organic anion transmembrane transporter activity
PANTHER GO-slim Biological Process:	transmembrane transport organic anion transport regulation of intracellular pH
PANTHER GO-slim Cellular Component:	basolateral plasma membrane
PANTHER protein class:	secondary carrier transporter

Pathway Categories:

No pathway information available

GENE ONTOLOGY DATABASE ANNOTATIONS

Click to Expand...

GO MF Complete:	protein homodimerization activity, ankyrin binding, chloride:bicarbonate antiporter activity, hemoglobin binding, solute:inorganic anion antiporter activity, chloride transmembrane transporter activity, bicarbonate transmembrane transporter activity
GO BP Complete:	regulation of intracellular pH, transmembrane transport, chloride transmembrane transport, plasma membrane phospholipid scrambling, negative regulation of urine volume, pH elevation, erythrocyte development, blood coagulation, chloride transport, bicarbonate transport, protein localization to plasma membrane, negative regulation of glycolytic process through fructose-6-phosphate
GO CC Complete:	Z disc, ankyrin-1 complex, basolateral plasma membrane, plasma membrane, cytoplasmic side of plasma membrane, cortical cytoskeleton

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Erythrocytes take up carbon dioxide and release oxygen, Transport of inorganic cations/anions and amino acids/oligopeptides, Erythrocytes take up oxygen and release carbon dioxide, O2/CO2 exchange in erythrocytes, Bicarbonate transporters, SLC-mediated transmembrane transport, Transport of small molecules

Orthologs

ID	Organism	Type
HUMAN\|HGNC=11027\|UniProtKB=P02730	Homo sapiens	LDO
PANTR\|Ensembl=ENSPTRG00000009270.6\|UniProtKB=H2QD68	Pan troglodytes	LDO
GORGO\|Ensembl=ENSGGOG00000010736.3\|UniProtKB=G3R5A5	Gorilla gorilla gorilla	LDO
MACMU\|Ensembl=ENSMMUG00000017100.4\|UniProtKB=F7H5B9	Macaca mulatta	LDO
MOUSE\|MGI=MGI=109393\|UniProtKB=P04919	Mus musculus	LDO
RAT\|RGD=3710\|UniProtKB=P23562	Rattus norvegicus	LDO
BOVIN\|Ensembl=ENSBTAG00000001610.6\|UniProtKB=F6QPG2	Bos taurus	LDO
PIG\|Ensembl=ENSSSCG00000017358.6\|UniProtKB=K7GR72	Sus scrofa	LDO
HORSE\|Ensembl=ENSECAG00000000527.4\|UniProtKB=Q2Z1P9	Equus caballus	LDO
FELCA\|Ensembl=ENSFCAG00000003051.6\|UniProtKB=M3VZM4	Felis catus	LDO
MONDO\|Ensembl=ENSMODG00000011613.4\|UniProtKB=A0A5F8G2Q0	Monodelphis domestica	LDO
ORNAN\|Ensembl=ENSOANG00000002629.3\|UniProtKB=F6SKS8	Ornithorhynchus anatinus	LDO
CHICK\|Gene=SLC4A1\|UniProtKB=P15575	Gallus gallus	O
CHICK\|Ensembl=ENSGALG00010024885.1\|UniProtKB=A0A8V1A0K9	Gallus gallus	LDO
ANOCA\|Ensembl=ENSACAG00000017228.4\|UniProtKB=G1KTP9	Anolis carolinensis	LDO
XENLA\|Gene=slc4a1.L\|UniProtKB=A0A1L8ESA4	Xenopus laevis	LDO
XENLA\|Gene=slc4a1.S\|UniProtKB=A0A8J0TYW1	Xenopus laevis	LDO
XENTR\|Xenbase=XB-GENE-986935\|UniProtKB=A0A6I8QVY8	Xenopus tropicalis	LDO
ORYLA\|Ensembl=ENSORLG00000002557.2\|UniProtKB=A0A3B3HN20	Oryzias latipes	O
ORYLA\|Ensembl=ENSORLG00000005495.2\|UniProtKB=H2LLK3	Oryzias latipes	LDO
DANRE\|ZFIN=ZDB-GENE-010525-1\|UniProtKB=Q7ZZJ7	Danio rerio	O
DANRE\|ZFIN=ZDB-GENE-110215-2\|UniProtKB=D1FTM8	Danio rerio	LDO
LEPOC\|Ensembl=ENSLOCG00000012065.1\|UniProtKB=W5N2L3	lepisosteus oculatus	LDO
CIOIN\|Ensembl=ENSCING00000021742.1\|UniProtKB=F7BGU9	Ciona intestinalis	O
CIOIN\|Ensembl=ENSCING00000003422.3\|UniProtKB=F6XL93	Ciona intestinalis	LDO
BRAFL\|Gene=LOC118406013\|UniProtKB=A0A9J7K971	Branchiostoma floridae	O
BRAFL\|Gene=LOC118405285\|UniProtKB=A0A9J7KIH3	Branchiostoma floridae	O
BRAFL\|Gene=LOC118405237\|UniProtKB=A0A9J7HNI3	Branchiostoma floridae	LDO
STRPU\|EnsemblGenome=LOC588892\|UniProtKB=A0A7M7N3L9	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC587119\|UniProtKB=A0A7M7N5M7	Strongylocentrotus purpuratus	LDO
CAEEL\|WormBase=WBGene00019844\|UniProtKB=Q58QG8	Caenorhabditis elegans	LDO
CAEBR\|Gene_ORFName=CBG10883\|UniProtKB=A8XC73	Caenorhabditis briggsae	LDO
PRIPA\|EnsemblGenome=WBGene00094941\|UniProtKB=A0A2A6BXS9	Pristionchus pacificus	LDO
DROME\|FlyBase=FBgn0036043\|UniProtKB=Q9VT48	Drosophila melanogaster	LDO
ANOGA\|EnsemblGenome=AGAP006968\|UniProtKB=Q7PT77	Anopheles gambiae	O
ANOGA\|EnsemblGenome=AGAP006115\|UniProtKB=A0A1S4GRA2	Anopheles gambiae	LDO
TRICA\|EnsemblGenome=TC032346\|UniProtKB=A0A139WM41	Tribolium castaneum	LDO
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g135965\|UniProtKB=A7SWX4	Nematostella vectensis	O
NEMVE\|Gene_ORFName=NEMVEDRAFT_v1g91031\|UniProtKB=A7RRK7	Nematostella vectensis	LDO
TRIAD\|EnsemblGenome=TriadG22844\|UniProtKB=B3RRA7	Trichoplax adhaerens	O
TRIAD\|EnsemblGenome=TriadG54168\|UniProtKB=B3RRA8	Trichoplax adhaerens	LDO
TRIV3\|Gene_ORFName=TVAG_055340\|UniProtKB=A2ETK2	Trichomonas vaginalis	O
THAPS\|EnsemblGenome=THAPSDRAFT_270361\|UniProtKB=B8BQB7	Thalassiosira pseudonana	O
PHYPA\|EnsemblGenome=Pp3c14_8980\|UniProtKB=A0A7I4ATU0	Physcomitrella patens	O
MARPO\|EnsemblGenome=MARPO_0052s0055\|UniProtKB=A0A2R6WWM0	Marchantia polymorpha	O