PANTHER Gene Information   
Gene Symbol(s): HAND2
Organism: Canis lupus familiaris
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Gene Name: Heart and neural crest derivatives expressed 2
Gene ID: ENSCAFG00845017182.1
Protein ID: A0A8I3PA17
Persistent Id: PTN009071221
Alternate Ids:
ENSCAFG00845017182(Ensembl) ENSCAFP00845023837(Ensembl_PRO)
A0A8I3PA17_CANLF(UniProtKB-ID) A0A8I3PA17(Synonym)
ENSCAFT00845030394(Ensembl_TRS)
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PANTHER Classification
PANTHER Family: BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, TWIST (PTHR23349)
PANTHER Subfamily: HEART- AND NEURAL CREST DERIVATIVES-EXPRESSED PROTEIN 2 (PTHR23349:SF41)  
PANTHER GO-slim Molecular Function: DNA-binding transcription factor activity, RNA polymerase II-specific
RNA polymerase II transcription regulatory region sequence-specific DNA binding
PANTHER GO-slim Biological Process: heart development
regulation of transcription by RNA polymerase II
PANTHER GO-slim Cellular Component:
PANTHER protein class: basic helix-loop-helix transcription factor
Pathway Categories: No pathway information available
GENE ONTOLOGY DATABASE ANNOTATIONS      Click to Expand...
GO MF Complete: protein homodimerization activity, RNA polymerase II-specific DNA-binding transcription factor binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, minor groove of adenine-thymine-rich DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, RNA polymerase II-specific, E-box binding
GO BP Complete: coronary artery morphogenesis, visceral serous pericardium development, negative regulation of epithelial cell apoptotic process, epithelial cell apoptotic process, odontogenesis of dentin-containing tooth, cardiac neural crest cell migration involved in outflow tract morphogenesis, tongue development, positive regulation of transcription by RNA polymerase II, apoptotic process involved in heart morphogenesis, peripheral nervous system neuron development, adult heart development, embryonic digit morphogenesis, negative regulation of osteoblast differentiation, thymus development, sympathetic nervous system development, heart development, in utero embryonic development, suckling behavior, osteoblast differentiation, heart looping, positive regulation of cardiac muscle hypertrophy, regulation of tissue remodeling, positive regulation of semaphorin-plexin signaling pathway, cartilage morphogenesis, norepinephrine biosynthetic process, embryonic skeletal system development, regulation of secondary heart field cardioblast proliferation, cell proliferation involved in outflow tract morphogenesis, regulation of transcription by RNA polymerase II, positive regulation of p38MAPK cascade, negative regulation of gene expression, primary palate development, cardiac right ventricle formation, positive regulation of gene expression, positive regulation of ERK1 and ERK2 cascade, negative regulation of cardiac muscle cell apoptotic process, mesenchymal cell proliferation
GO CC Complete: nucleus, transcription regulator complex, chromatin
REACTOME DATABASE ANNOTATIONS   Click to Expand...
Reactome Pathways: -

Orthologs