PANTHER Gene Information   
Gene Symbol(s): HAND2
Organism: Macaca mulatta
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Gene Name: Heart and neural crest derivatives expressed 2
Gene ID: ENSMMUG00000048816.2
Protein ID: F7H124
Persistent Id: PTN002763434
Alternate Ids:
ENSMMUT00000041498(Ensembl_TRS) NP_001180694(refSeq)
F7H124(Synonym) ENSMMUG00000048816(Ensembl)
696881(GeneID) F7H124_MACMU(UniProtKB-ID)
302563457(GI) ENSMMUP00000034525(Ensembl_PRO)
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PANTHER Classification
PANTHER Family: BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, TWIST (PTHR23349)
PANTHER Subfamily: HEART- AND NEURAL CREST DERIVATIVES-EXPRESSED PROTEIN 2 (PTHR23349:SF41)  
PANTHER GO-slim Molecular Function: DNA-binding transcription factor activity, RNA polymerase II-specific
RNA polymerase II transcription regulatory region sequence-specific DNA binding
PANTHER GO-slim Biological Process: heart development
regulation of transcription by RNA polymerase II
PANTHER GO-slim Cellular Component:
PANTHER protein class: basic helix-loop-helix transcription factor
Pathway Categories: No pathway information available
GO MF Complete: protein homodimerization activity, RNA polymerase II-specific DNA-binding transcription factor binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, transcription cis-regulatory region binding, minor groove of adenine-thymine-rich DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, sequence-specific DNA binding, protein dimerization activity, sequence-specific double-stranded DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, E-box binding
GO BP Complete: mesenchyme development, coronary artery morphogenesis, determination of heart left/right asymmetry, visceral serous pericardium development, negative regulation of epithelial cell apoptotic process, roof of mouth development, outflow tract morphogenesis, epithelial cell apoptotic process, odontogenesis of dentin-containing tooth, cardiac neural crest cell migration involved in outflow tract morphogenesis, tongue development, positive regulation of transcription by RNA polymerase II, apoptotic process involved in heart morphogenesis, peripheral nervous system neuron development, adult heart development, embryonic digit morphogenesis, negative regulation of osteoblast differentiation, thymus development, sympathetic nervous system development, heart development, heart morphogenesis, in utero embryonic development, positive regulation of DNA-templated transcription, suckling behavior, apoptotic process, osteoblast differentiation, heart looping, positive regulation of cardiac muscle hypertrophy, regulation of tissue remodeling, positive regulation of semaphorin-plexin signaling pathway, neural crest cell development, cartilage morphogenesis, regulation of DNA-templated transcription, norepinephrine biosynthetic process, cardiac neural crest cell development involved in outflow tract morphogenesis, embryonic skeletal system development, regulation of secondary heart field cardioblast proliferation, cell proliferation involved in outflow tract morphogenesis, regulation of transcription by RNA polymerase II, positive regulation of p38MAPK cascade, negative regulation of gene expression, primary palate development, cardiac right ventricle formation, positive regulation of gene expression, positive regulation of ERK1 and ERK2 cascade, negative regulation of cardiac muscle cell apoptotic process, mesenchymal cell proliferation
GO CC Complete: nucleus, transcription regulator complex, protein-containing complex, chromatin
Reactome Pathways: -