PANTHER Gene Information   
Gene Symbol(s): MYD88
Organism: Canis lupus familiaris
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Gene Name: Myeloid differentiation primary response protein MyD88
Gene ID: ENSCAFG00845029799.1
Protein ID: A0A8I3Q209
Persistent Id: PTN009022608
Alternate Ids:
ENSCAFT00845052792(Ensembl_TRS) A0A8I3Q209_CANLF(UniProtKB-ID)
ENSCAFG00845029799(Ensembl) A0A8I3Q209(Synonym)
ENSCAFP00845041446(Ensembl_PRO)
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PANTHER Classification
PANTHER Family: MYD88 (PTHR15079)
PANTHER Subfamily: MYELOID DIFFERENTIATION PRIMARY RESPONSE PROTEIN MYD88 (PTHR15079:SF3)  
PANTHER GO-slim Molecular Function:
PANTHER GO-slim Biological Process:
PANTHER GO-slim Cellular Component:
PANTHER protein class: scaffold/adaptor protein
Pathway Categories: Toll receptor signaling pathway
   myeloid differentiation factor 88
Toll pathway-drosophila
   MyD88
GENE ONTOLOGY DATABASE ANNOTATIONS      Click to Expand...
GO MF Complete: identical protein binding, signaling adaptor activity, ATP-dependent histone chaperone activity, interleukin-1 receptor binding, Toll-like receptor binding, TIR domain binding
GO BP Complete: Toll signaling pathway, response to peptidoglycan, neutrophil activation involved in immune response, JNK cascade, skin development, positive regulation of cytokine production involved in inflammatory response, response to molecule of fungal origin, MyD88-dependent toll-like receptor signaling pathway, positive regulation of lymphocyte proliferation, apoptotic process, defense response to virus, positive regulation of tumor necrosis factor production, toll-like receptor 5 signaling pathway, positive regulation of chemokine production, defense response to Gram-positive bacterium, induced systemic resistance, positive regulation of type I interferon production, toll-like receptor 4 signaling pathway, positive regulation of NLRP3 inflammasome complex assembly, positive regulation of interleukin-8 production, gene expression, lipopolysaccharide-mediated signaling pathway, regulation of inflammatory response, positive regulation of interleukin-6 production, microglia differentiation, establishment of endothelial intestinal barrier, interleukin-33-mediated signaling pathway, positive regulation of canonical NF-kappaB signal transduction, positive regulation of transcription by RNA polymerase II, positive regulation of macrophage cytokine production, chromatin remodeling, positive regulation of interleukin-23 production, regulation of chemokine (C-X-C motif) ligand 1 production, positive regulation of interleukin-17 production, neutrophil-mediated killing of bacterium, toll-like receptor TLR6:TLR2 signaling pathway, 3'-UTR-mediated mRNA stabilization, cellular response to oxidised low-density lipoprotein particle stimulus, regulation of neutrophil migration, type I interferon-mediated signaling pathway, leukocyte activation involved in inflammatory response, cellular response to mechanical stimulus, innate immune response, positive regulation of JNK cascade, immunoglobulin mediated immune response, phagocytosis, toll-like receptor 8 signaling pathway, interleukin-1-mediated signaling pathway, regulation of chemokine (C-X-C motif) ligand 2 production, positive regulation of interleukin-1 beta production
GO CC Complete: nucleus, cytosol, extrinsic component of cytoplasmic side of plasma membrane, plasma membrane, cell surface
REACTOME DATABASE ANNOTATIONS   Click to Expand...
Reactome Pathways: Interleukin-1 signaling, RIP-mediated NFkB activation via ZBP1, Signaling by Interleukins, Interleukin-1 family signaling, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling, Innate Immune System, Signal Transduction, Death Receptor Signaling, Cytosolic sensors of pathogen-associated DNA , PIP3 activates AKT signaling, DEx/H-box helicases activate type I IFN and inflammatory cytokines production , Immune System, Cytokine Signaling in Immune system, Intracellular signaling by second messengers, ZBP1(DAI) mediated induction of type I IFNs, p75 NTR receptor-mediated signalling, p75NTR recruits signalling complexes, Negative regulation of the PI3K/AKT network, p75NTR signals via NF-kB

Orthologs