PANTHER Gene Information

Gene Symbol(s):

psen1

Organism:

Danio rerio

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Gene Name:

Presenilin-1

Gene ID:

ZDB-GENE-991119-4

Protein ID:

Q9W6T7

Persistent Id:

PTN000024482

Alternate Ids:

psen1(Symbol)	AJ132931(EMBL)
ZDB-GENE-991119-4(ZFIN)	PSN1(Synonym)
PSN1_DANRE(UniProtKB-ID)	30221(GeneID)
3.4.23.- {ECO:0000269\|PubMed:10521267}(EC)	NM_131024(refSeq)
CAB40386(EMBL-CDS)	4583564(GI)
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PANTHER Classification

PANTHER Family:	PRESENILIN (PTHR10202)
PANTHER Subfamily:	PRESENILIN-1 (PTHR10202:SF18)
PANTHER GO-slim Molecular Function:	aspartic-type endopeptidase activity
PANTHER GO-slim Biological Process:	membrane protein ectodomain proteolysis peptide metabolic process Notch signaling pathway protein processing calcium ion homeostasis
PANTHER GO-slim Cellular Component:	catalytic complex plasma membrane protein complex
PANTHER protein class:	aspartic protease

Pathway Categories:

Alzheimer disease-presenilin pathway

Presenilin

Notch signaling pathway

Presenilin

Alzheimer disease-amyloid secretase pathway

Presenilin

Alzheimer disease-presenilin pathway

Presenilin N-terminal fragment

Alzheimer disease-amyloid secretase pathway

Presenilin C-terminal fragment

Alzheimer disease-amyloid secretase pathway

Presenilin N-terminal fragment

Alzheimer disease-presenilin pathway

Presenilin C-terminal fragment

GENE ONTOLOGY DATABASE ANNOTATIONS

Click to Expand...

GO MF Complete:	aspartic-type endopeptidase activity, peptidase activity, aspartic endopeptidase activity, intramembrane cleaving, hydrolase activity
GO BP Complete:	calcium ion homeostasis, somite development, brain development, melanocyte differentiation, response to hypoxia, Notch signaling pathway, membrane protein ectodomain proteolysis, regulation of canonical Wnt signaling pathway, proteolysis, lymphangiogenesis, canonical Wnt signaling pathway, protein processing, optomotor response, swimming behavior, regulation of endopeptidase activity, amyloid-beta formation
GO CC Complete:	endoplasmic reticulum membrane, mitochondrion, membrane, gamma-secretase complex, Golgi membrane, endoplasmic reticulum, Golgi apparatus, synapse, cell projection, plasma membrane, axon

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

EPH-ephrin mediated repulsion of cells, Signaling by Receptor Tyrosine Kinases, Death Receptor Signaling, Neutrophil degranulation, Axon guidance, Nervous system development, p75 NTR receptor-mediated signalling, Signal Transduction, Nuclear signaling by ERBB4, EPH-Ephrin signaling, Signaling by ERBB4, Immune System, Innate Immune System, Developmental Biology, Regulated proteolysis of p75NTR

Orthologs

ID	Organism	Type
HUMAN\|HGNC=9508\|UniProtKB=P49768	Homo sapiens	LDO
PANTR\|Ensembl=ENSPTRG00000006510.6\|UniProtKB=H2Q8K1	Pan troglodytes	LDO
GORGO\|Ensembl=ENSGGOG00000002132.3\|UniProtKB=G3QI95	Gorilla gorilla gorilla	LDO
MACMU\|Ensembl=ENSMMUG00000010173.4\|UniProtKB=F7AGU8	Macaca mulatta	LDO
MOUSE\|MGI=MGI=1202717\|UniProtKB=P49769	Mus musculus	LDO
RAT\|RGD=3425\|UniProtKB=P97887	Rattus norvegicus	LDO
BOVIN\|Ensembl=ENSBTAG00000011757\|UniProtKB=Q9XT97	Bos taurus	LDO
PIG\|Ensembl=ENSSSCG00000002340.6\|UniProtKB=F1S3K9	Sus scrofa	LDO
HORSE\|Ensembl=ENSECAG00000004387.4\|UniProtKB=F6SAM1	Equus caballus	LDO
FELCA\|Ensembl=ENSFCAG00000028093.4\|UniProtKB=A0A337SCH4	Felis catus	LDO
CANLF\|Gene=PSEN1\|UniProtKB=Q6RH31	Canis lupus familiaris	O
CANLF\|Ensembl=ENSCAFG00845012166.1\|UniProtKB=A0A8I3RZ86	Canis lupus familiaris	LDO
MONDO\|Ensembl=ENSMODG00000006792.3\|UniProtKB=A0A5F8HEL5	Monodelphis domestica	LDO
ORNAN\|Ensembl=ENSOANG00000001055.4\|UniProtKB=F6PHW7	Ornithorhynchus anatinus	LDO
CHICK\|Ensembl=ENSGALG00010020984.1\|UniProtKB=A0A3Q2UE42	Gallus gallus	LDO
CHICK\|Gene=PSEN1\|UniProtKB=Q4JIM4	Gallus gallus	LDO
ANOCA\|Ensembl=ENSACAG00000016176.4\|UniProtKB=A0A803SNS1	Anolis carolinensis	LDO
XENLA\|Gene=psen1.L\|UniProtKB=A0A8J0THZ4	Xenopus laevis	O
XENLA\|Gene=psen1\|UniProtKB=O12976	Xenopus laevis	O
XENLA\|Gene=psen1.S\|UniProtKB=A0A1L8EZY9	Xenopus laevis	LDO
XENTR\|Xenbase=XB-GENE-481916\|UniProtKB=A0A803K579	Xenopus tropicalis	LDO
ORYLA\|Ensembl=ENSORLG00000022179.1\|UniProtKB=A0A3B3ILF1	Oryzias latipes	LDO
LEPOC\|Ensembl=ENSLOCG00000013357.1\|UniProtKB=W5N759	lepisosteus oculatus	LDO
CIOIN\|Ensembl=ENSCING00000002361.3\|UniProtKB=F6RA92	Ciona intestinalis	O
BRAFL\|Gene=LOC118418980\|UniProtKB=A0A9J7MWD5	Branchiostoma floridae	O
STRPU\|EnsemblGenome=LOC578066\|UniProtKB=A0A7M7T5N2	Strongylocentrotus purpuratus	O
CAEEL\|WormBase=WBGene00004958\|UniProtKB=Q01608	Caenorhabditis elegans	O
CAEBR\|WormBase=WBGene00032967\|UniProtKB=G2J6Q7	Caenorhabditis briggsae	O
PRIPA\|EnsemblGenome=WBGene00278263\|UniProtKB=A0A2A6BII2	Pristionchus pacificus	O
PRIPA\|EnsemblGenome=WBGene00115594\|UniProtKB=A0A2A6BL51	Pristionchus pacificus	O
CAEEL\|WormBase=WBGene00001985\|UniProtKB=O02100	Caenorhabditis elegans	O
CAEBR\|WormBase=WBGene00033101\|UniProtKB=A8XEJ8	Caenorhabditis briggsae	O
CAEEL\|WormBase=WBGene00004769\|UniProtKB=P52166	Caenorhabditis elegans	O
CAEBR\|WormBase=WBGene00029955\|UniProtKB=A8X5S7	Caenorhabditis briggsae	O
PRIPA\|EnsemblGenome=WBGene00276783\|UniProtKB=A0A454XXP0	Pristionchus pacificus	O
DROME\|FlyBase=FBgn0284421\|UniProtKB=O02194	Drosophila melanogaster	O
ANOGA\|EnsemblGenome=AGAP002957\|UniProtKB=Q7PR98	Anopheles gambiae	O
TRICA\|EnsemblGenome=TC010178\|UniProtKB=D6WT91	Tribolium castaneum	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_205191\|UniProtKB=E9FSB0	Daphnia pulex	O
IXOSC\|EnsemblGenome=ISCW003378\|UniProtKB=B7P928	Ixodes scapularis	O
IXOSC\|EnsemblGenome=ISCW022390\|UniProtKB=B7QGI2	Ixodes scapularis	O
IXOSC\|EnsemblGenome=ISCW020583\|UniProtKB=B7Q2V0	Ixodes scapularis	O
HELRO\|EnsemblGenome=HelroG87358\|UniProtKB=T1G6P3	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG114139\|UniProtKB=T1EFZ6	helobdella robusta	O
TRIAD\|EnsemblGenome=TriadG57183\|UniProtKB=B3S0V5	Trichoplax adhaerens	O
MONBE\|EnsemblGenome=MONBRDRAFT_29512\|UniProtKB=A9VBA9	Monosiga brevicollis	O
ENTH1\|EnsemblGenome=CL6EHI_188280\|UniProtKB=C4M1A2	Entamoeba histolytica	O
DICDI\|dictyBase=DDB_G0291352\|UniProtKB=Q54ET2	Dictyostelium discoideum	O
DICPU\|EnsemblGenome=DICPUDRAFT_87693\|UniProtKB=F0ZJS7	Dictyostelium purpureum	O
DICDI\|dictyBase=DDB_G0292310\|UniProtKB=Q54DE8	Dictyostelium discoideum	O
DICPU\|EnsemblGenome=DICPUDRAFT_51947\|UniProtKB=F1A6B3	Dictyostelium purpureum	O
LEIMA\|EnsemblGenome=LMJF_15_1530\|UniProtKB=Q4QF26	Leishmania major	O
TRYB2\|Gene_ORFName=Tb09.160.3510\|UniProtKB=Q38F54	Trypanosoma brucei	O
TRIV3\|Gene_ORFName=TVAG_026700\|UniProtKB=A2DZ73	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_428310\|UniProtKB=A2G9L8	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_412920\|UniProtKB=A2F6H8	Trichomonas vaginalis	O
THAPS\|EnsemblGenome=THAPSDRAFT_261548\|UniProtKB=B8BVL0	Thalassiosira pseudonana	O
THAPS\|EnsemblGenome=THAPSDRAFT_268976\|UniProtKB=B8C3Y7	Thalassiosira pseudonana	O
PHYRM\|Gene=H3GSQ0_PHYRM\|UniProtKB=H3GSQ0	Phytophthora ramorum	O
PHYRM\|Gene=H3GE34_PHYRM\|UniProtKB=H3GE34	Phytophthora ramorum	O
CHLRE\|EnsemblGenome=CHLRE_02g078858v5\|UniProtKB=A0A2K3E0E4	Chlamydomonas reinhardtii	O
AMBTC\|EnsemblGenome=AMTR_s00119p00061920\|UniProtKB=W1NQ31	Amborella trichopoda	O
ZOSMR\|Gene_ORFName=ZOSMA_74G00250\|UniProtKB=A0A0K9NPJ2	Zostera marina	O
MUSAM\|EnsemblGenome=Ma05_g07460\|UniProtKB=A0A804J1Y4	Musa acuminata subsp. malaccensis	O
SETIT\|EnsemblGenome=SETIT_001249mg\|UniProtKB=K3XH78	Setaria italica	O
SORBI\|EnsemblGenome=SORBI_3003G130500\|UniProtKB=C5XH90	Sorghum bicolor	O
MAIZE\|EnsemblGenome=Zm00001eb128860\|UniProtKB=A0A804N249	Zea mays	O
MAIZE\|EnsemblGenome=Zm00001eb332720\|UniProtKB=B6TCG9	Zea mays	O
ORYSJ\|EnsemblGenome=Os01g0276400\|UniProtKB=A0A0P0V1R2	Oryza sativa	O
BRADI\|EnsemblGenome=BRADI_2g10480v3\|UniProtKB=A0A0Q3ITY7	Brachypodium distachyon	O
HORVV\|EnsemblGenome=HORVU.MOREX.r3.3HG0257130\|UniProtKB=F2CQD9	Hordeum vulgare subsp. vulgare	O
WHEAT\|EnsemblGenome=TraesCS3A02G189100\|UniProtKB=A0A3B6EFK6	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS3B02G218100\|UniProtKB=A0A3B6FLQ8	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS3D02G192400\|UniProtKB=A0A3B6GUU3	Triticum aestivum	O
NELNU\|Gene_ORFName=HUJ06_030740\|UniProtKB=A0A1U7ZEC8	Nelumbo nucifera	O
SPIOL\|Gene=LOC110795153\|UniProtKB=A0A9R0IX21	Spinacia oleracea	O
HELAN\|EnsemblGenome=HanXRQr2_Chr06g0259241\|UniProtKB=A0A251UI93	Helianthus annuus	O
LACSA\|Gene_ORFName=LSAT_V11C800422800\|UniProtKB=A0A9R1UPM9	Lactuca sativa	O
ERYGU\|Gene_ORFName=MIMGU_mgv1a006808mg\|UniProtKB=A0A022R9S5	Erythranthe guttata	O
SOLTU\|EnsemblGenome=PGSC0003DMG400028205\|UniProtKB=M1CQE1	Solanum tuberosum	O
SOLLC\|EnsemblGenome=Solyc10g081230.2\|UniProtKB=A0A3Q7IL79	Solanum lycopersicum	O
TOBAC\|Gene=LOC107765978\|UniProtKB=A0A1S3XK05	Nicotiana tabacum	O
TOBAC\|Gene=LOC107802357\|UniProtKB=A0A1S4AXB7	Nicotiana tabacum	O
VITVI\|EnsemblGenome=Vitvi08g00072\|UniProtKB=F6HMV3	Vitis vinifera	O
EUCGR\|EnsemblGenome=EUGRSUZ_K01546\|UniProtKB=A0A059A286	Eucalyptus grandis	O
BRACM\|EnsemblGenome=Bra018606\|UniProtKB=M4DQ15	Brassica campestris	O
ARATH\|TAIR=locus=2025640\|UniProtKB=O64668	Arabidopsis thaliana	O
GOSHI\|Gene=LOC107890049\|UniProtKB=A0A1U8I1H6	Gossypium hirsutum	O
GOSHI\|Gene=LOC107948937\|UniProtKB=A0A1U8NMF4	Gossypium hirsutum	O
THECC\|EnsemblGenome=TCM_025793\|UniProtKB=A0A061F038	Theobroma cacao	O
CITSI\|Gene_ORFName=CISIN_1g013051mg\|UniProtKB=A0A067E5X1	Citrus sinensis	O
POPTR\|EnsemblGenome=POPTR_013G067700v3\|UniProtKB=A0A2K1Y252	Populus trichocarpa	O
MANES\|EnsemblGenome=MANES_08G150800\|UniProtKB=A0A2C9VGG5	Manihot esculenta	O
MANES\|EnsemblGenome=MANES_09G135600\|UniProtKB=A0A2C9VC94	Manihot esculenta	O
RICCO\|Gene_ORFName=RCOM_0845230\|UniProtKB=B9SY83	Ricinus communis	O
SOYBN\|EnsemblGenome=GLYMA_19G119800\|UniProtKB=I1N8G3	Glycine max	O
SOYBN\|EnsemblGenome=GLYMA_03G006300\|UniProtKB=I1JK51	Glycine max	O
MEDTR\|EnsemblGenome=MTR_7g087200\|UniProtKB=G7L2M4	Medicago truncatula	O
JUGRE\|EnsemblGenome=Jr03_20120\|UniProtKB=A0A2I4GFG6	Juglans regia	O
CUCSA\|EnsemblGenome=Csa_4G417500\|UniProtKB=A0A0A0L3E5	Cucumis sativus	O
PRUPE\|EnsemblGenome=PRUPE_5G048300\|UniProtKB=M5WAI2	Prunus persica	O
AMBTC\|EnsemblGenome=AMTR_s00154p00031240\|UniProtKB=W1PC62	Amborella trichopoda	O
ZOSMR\|Gene_ORFName=ZOSMA_50G00620\|UniProtKB=A0A0K9P098	Zostera marina	O
MUSAM\|EnsemblGenome=Ma04_g29950\|UniProtKB=A0A804IVI3	Musa acuminata subsp. malaccensis	O
SETIT\|EnsemblGenome=SETIT_035617mg\|UniProtKB=K4A9R1	Setaria italica	O
SORBI\|EnsemblGenome=SORBI_3001G171500\|UniProtKB=A0A1B6QJF6	Sorghum bicolor	O
MAIZE\|EnsemblGenome=Zm00001eb219250\|UniProtKB=A0A1D6GLV1	Zea mays	O
ORYSJ\|EnsemblGenome=Os03g0603800\|UniProtKB=C7J054	Oryza sativa	O
BRADI\|EnsemblGenome=BRADI_1g14960v3\|UniProtKB=A0A0Q3RMS2	Brachypodium distachyon	O
HORVV\|EnsemblGenome=HORVU.MOREX.r3.4HG0342160\|UniProtKB=F2EGF7	Hordeum vulgare subsp. vulgare	O
WHEAT\|EnsemblGenome=TraesCS4D02G075300\|UniProtKB=A0A3B6JDQ4	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS4A02G238100\|UniProtKB=A0A3B6HYQ3	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS4B02G076800\|UniProtKB=A0A3B6IKZ6	Triticum aestivum	O
NELNU\|Gene_ORFName=HUJ06_005686\|UniProtKB=A0A1U8A559	Nelumbo nucifera	O
SPIOL\|Gene=LOC110795635\|UniProtKB=A0A9R0K3L9	Spinacia oleracea	O
HELAN\|EnsemblGenome=HanXRQr2_Chr09g0408231\|UniProtKB=A0A251U0K1	Helianthus annuus	O
LACSA\|Gene_ORFName=LSAT_V11C400200950\|UniProtKB=A0A9R1VSY6	Lactuca sativa	O
ERYGU\|Gene_ORFName=MIMGU_mgv1a026313mg\|UniProtKB=A0A022RMU2	Erythranthe guttata	O
CAPAN\|EnsemblGenome=T459_10444\|UniProtKB=A0A2G3A286	Capsicum annuum	O
CAPAN\|EnsemblGenome=T459_10442\|UniProtKB=A0A2G3A294	Capsicum annuum	O
SOLTU\|EnsemblGenome=PGSC0003DMG400024636\|UniProtKB=M1CAI2	Solanum tuberosum	O
SOLLC\|EnsemblGenome=Solyc03g115075.1\|UniProtKB=A0A3Q7FSU6	Solanum lycopersicum	O
TOBAC\|Gene=LOC107823683\|UniProtKB=A0A1S4CXH8	Nicotiana tabacum	O
TOBAC\|Gene=LOC107790304\|UniProtKB=A0A1S3ZTL3	Nicotiana tabacum	O
VITVI\|EnsemblGenome=Vitvi17g00712\|UniProtKB=F6GSZ0	Vitis vinifera	O
BRANA\|Gene_ORFName=DARMORV10_C04P20920.1\|UniProtKB=A0A078JFQ8	Brassica napus	O
BRANA\|Gene_ORFName=DARMORV10_A05P15530.1\|UniProtKB=A0A078J4P4	Brassica napus	O
BRACM\|EnsemblGenome=Bra018354\|UniProtKB=M4DPB3	Brassica campestris	O
ARATH\|TAIR=locus=2052080\|UniProtKB=Q9SIK7	Arabidopsis thaliana	O
GOSHI\|Gene=LOC107941447\|UniProtKB=A0A1U8MY34	Gossypium hirsutum	O
GOSHI\|Gene=LOC107953480\|UniProtKB=A0A1U8P253	Gossypium hirsutum	O
THECC\|EnsemblGenome=TCM_014267\|UniProtKB=A0A061FYV6	Theobroma cacao	O
CITSI\|Gene_ORFName=CISIN_1g013935mg\|UniProtKB=A0A067FHZ3	Citrus sinensis	O
MANES\|EnsemblGenome=MANES_06G084500\|UniProtKB=A0A2C9VP23	Manihot esculenta	O
RICCO\|Gene_ORFName=RCOM_1469710\|UniProtKB=B9RLN5	Ricinus communis	O
SOYBN\|EnsemblGenome=GLYMA_05G020800\|UniProtKB=I1JZI3	Glycine max	O
SOYBN\|EnsemblGenome=GLYMA_17G078500\|UniProtKB=I1MT67	Glycine max	O
MEDTR\|EnsemblGenome=MTR_4g109550\|UniProtKB=A0A072UQB9	Medicago truncatula	O
JUGRE\|EnsemblGenome=Jr02_07000\|UniProtKB=A0A2I4EZP0	Juglans regia	O
CUCSA\|EnsemblGenome=Csa_1G039210\|UniProtKB=A0A0A0LQ93	Cucumis sativus	O
PRUPE\|EnsemblGenome=PRUPE_5G205400\|UniProtKB=M5W9E2	Prunus persica	O
SELML\|EnsemblGenome=SELMODRAFT_55385\|UniProtKB=D8RGP0	Selaginella moellendorffii	O
PHYPA\|EnsemblGenome=Pp3c3_30410\|UniProtKB=A9S846	Physcomitrella patens	O
MARPO\|EnsemblGenome=MARPO_0001s0218\|UniProtKB=A0A2R6XVP7	Marchantia polymorpha	O
KLENI\|Gene_ORFName=KFL_003960070\|UniProtKB=A0A1Y1IH42	Klebsormidium nitens	O