PANTHER Gene Information   
Gene Symbol(s): PSEN1
Organism: Gorilla gorilla gorilla
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Gene Name: Presenilin
Gene ID: ENSGGOG00000002132.3
Protein ID: G3QI95
Persistent Id: PTN002565797
Alternate Ids:
ENSGGOP00000002100(Ensembl_PRO) G3QI95_GORGO(UniProtKB-ID)
CABD030093140(EMBL) ENSGGOG00000002132(Ensembl)
ENSGGOT00000002145(Ensembl_TRS) G3QI95(Synonym)
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PANTHER Classification
PANTHER Family: PRESENILIN (PTHR10202)
PANTHER Subfamily: PRESENILIN-1 (PTHR10202:SF18)  
PANTHER GO-slim Molecular Function: aspartic-type endopeptidase activity
PANTHER GO-slim Biological Process: membrane protein ectodomain proteolysis
peptide metabolic process
Notch signaling pathway
protein processing
calcium ion homeostasis
PANTHER GO-slim Cellular Component: catalytic complex
plasma membrane protein complex
PANTHER protein class: aspartic protease
Pathway Categories: Alzheimer disease-presenilin pathway
   Presenilin
Notch signaling pathway
   Presenilin
Alzheimer disease-amyloid secretase pathway
   Presenilin
Alzheimer disease-presenilin pathway
   Presenilin N-terminal fragment
Alzheimer disease-amyloid secretase pathway
   Presenilin C-terminal fragment
Alzheimer disease-amyloid secretase pathway
   Presenilin N-terminal fragment
Alzheimer disease-presenilin pathway
   Presenilin C-terminal fragment
GENE ONTOLOGY DATABASE ANNOTATIONS      Click to Expand...
GO MF Complete: aspartic-type endopeptidase activity, calcium channel activity, cadherin binding, endopeptidase activity, PDZ domain binding, beta-catenin binding, peptidase activity, growth factor receptor binding, aspartic endopeptidase activity, intramembrane cleaving, ATPase binding
GO BP Complete: segmentation, post-embryonic development, protein transport, neurogenesis, skin morphogenesis, hematopoietic progenitor cell differentiation, cerebral cortex cell migration, epithelial cell proliferation, mitochondrial transport, positive regulation of DNA-templated transcription, heart looping, cell fate specification, amyloid-beta metabolic process, intracellular signal transduction, neuron apoptotic process, positive regulation of protein import into nucleus, regulation of resting membrane potential, positive regulation of dendritic spine development, brain development, DNA damage response, synaptic vesicle targeting, neuron projection maintenance, protein processing, positive regulation of proteasomal ubiquitin-dependent protein catabolic process, calcium ion homeostasis, locomotion, apoptotic signaling pathway, positive regulation of glycolytic process, thymus development, autophagosome assembly, heart development, astrocyte activation, neuron migration, positive regulation of receptor recycling, L-glutamate import across plasma membrane, myeloid dendritic cell differentiation, regulation of canonical Wnt signaling pathway, calcium ion transmembrane transport, T cell receptor signaling pathway, amyloid-beta formation, cellular response to amyloid-beta, neuron development, skeletal system morphogenesis, regulation of synaptic vesicle cycle, neuron cellular homeostasis, protein catabolic process at postsynapse, cell-cell adhesion, negative regulation of apoptotic signaling pathway, choline transport, protein glycosylation, T cell activation involved in immune response, Cajal-Retzius cell differentiation, memory, learning or memory, positive regulation of L-glutamate import across plasma membrane, smooth endoplasmic reticulum calcium ion homeostasis, forebrain development, autophagy, apoptotic process, regulation of synaptic plasticity, positive regulation of tumor necrosis factor production, sequestering of calcium ion, protein maturation, regulation of neuron projection development, regulation of synaptic transmission, glutamatergic, dorsal/ventral neural tube patterning, amyloid precursor protein catabolic process, Notch receptor processing, neuron differentiation, synapse organization, cerebral cortex development, amyloid precursor protein metabolic process, myeloid leukocyte differentiation, negative regulation of gene expression, positive regulation of amyloid fibril formation, Notch signaling pathway, somitogenesis, positive regulation of gene expression, regulation of gene expression, gene expression, cell adhesion, brain morphogenesis, astrocyte activation involved in immune response, regulation of postsynapse organization, negative regulation of transcription by RNA polymerase II, response to oxidative stress, embryonic limb morphogenesis, negative regulation of axonogenesis, blood vessel development, endoplasmic reticulum calcium ion homeostasis, negative regulation of ubiquitin-dependent protein catabolic process, intracellular calcium ion homeostasis, membrane protein ectodomain proteolysis, negative regulation of apoptotic process, proteolysis, positive regulation of apoptotic process, positive regulation of coagulation
GO CC Complete: smooth endoplasmic reticulum, rough endoplasmic reticulum, Golgi membrane, Golgi apparatus, kinetochore, neuronal cell body, synapse, cell projection, neuron projection, nucleoplasm, endoplasmic reticulum membrane, growth cone, dendrite, presynapse, postsynapse, dendritic shaft, cytoplasmic vesicle, gamma-secretase complex, glutamatergic synapse, aggresome, axon, ciliary rootlet, nuclear outer membrane, endoplasmic reticulum, plasma membrane, early endosome membrane, nucleus, centrosome, nuclear membrane, cytoplasm, cell cortex, mitochondrion, membrane, membrane raft, cell junction, protein-containing complex
REACTOME DATABASE ANNOTATIONS   Click to Expand...
Reactome Pathways: -

Orthologs