PANTHER Gene Information   
Gene Symbol(s): foxo
Organism: Drosophila melanogaster
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Gene Name: Forkhead box protein O
Gene ID: FBgn0038197
Protein ID: Q95V55
Persistent Id: PTN000215244
Alternate Ids:
AAF55012(EMBL-CDS) 386765716(GI)
41709(GeneID) FBgn0038197(Ensembl)
Protein FKHR(Synonym) FBgn0038197(FlyBase)
AF416728(EMBL) foxo{ECO:0000312|EMBL:AAS65148.1}(Symbol)
FOXO_DROME(UniProtKB-ID) NM_001275628(refSeq)
Q9VFN8(AltAccession)
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PANTHER Classification
PANTHER Family: FORKHEAD BOX PROTEIN O (PTHR45767)
PANTHER Subfamily: FORKHEAD BOX PROTEIN O (PTHR45767:SF2)  
PANTHER GO-slim Molecular Function: DNA-binding transcription factor activity, RNA polymerase II-specific
RNA polymerase II cis-regulatory region sequence-specific DNA binding
PANTHER GO-slim Biological Process: regulation of transcription by RNA polymerase II
PANTHER GO-slim Cellular Component: nucleus
PANTHER protein class: winged helix/forkhead transcription factor
Pathway Categories: Insulin/IGF pathway-protein kinase B signaling cascade
   Forkhead transcription factor
GENE ONTOLOGY DATABASE ANNOTATIONS      Click to Expand...
GO MF Complete: DNA-binding transcription factor activity, protein binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, sequence-specific DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific
GO BP Complete: negative regulation of multicellular organism growth, peptidoglycan recognition protein signaling pathway, insulin receptor signaling pathway, negative regulation of cell population proliferation, determination of adult lifespan, cellular response to amino acid starvation, female germ-line stem cell population maintenance, response to starvation, positive regulation of transcription by RNA polymerase II, negative regulation of innate immune response, dendrite morphogenesis, negative regulation of transcription by RNA polymerase II, response to oxidative stress, compound eye morphogenesis, negative regulation of cell growth, locomotor rhythm, lymph gland development, negative regulation of cell size, positive regulation of triglyceride catabolic process, negative regulation of fat cell proliferation, positive regulation of feeding behavior, negative regulation of wound healing, positive regulation of octopamine signaling pathway, regulation of DNA-templated transcription, regulation of organ growth, cellular response to starvation, circadian rhythm, regulation of growth, negative regulation of insulin receptor signaling pathway, regulation of transcription by RNA polymerase II, positive regulation of entry into reproductive diapause, positive regulation of autophagy, response to bacterium, regulation of autophagy, glucose homeostasis, regulation of macroautophagy, regulation of hemocyte proliferation, cellular response to oxidative stress, negative regulation of lipid storage, regulation of lipid metabolic process
GO CC Complete: nucleus, cytoplasm, cytosol
REACTOME DATABASE ANNOTATIONS   Click to Expand...
Reactome Pathways: FOXO-mediated transcription, Regulation of gene expression in beta cells, ESR-mediated signaling, Deubiquitination, Extra-nuclear estrogen signaling, MAPK family signaling cascades, Signal Transduction, Gene expression (Transcription), Signaling by NODAL, Post-translational protein modification, Regulation of beta-cell development, Insulin receptor mediated signaling, Signaling by Nuclear Receptors, AKT phosphorylates targets in the nucleus, RNA Polymerase II Transcription, PIP3 activates AKT signaling, Regulation of localization of FOXO transcription factors, MAPK6/MAPK4 signaling, Generic Transcription Pathway, Immune System, FLT3 Signaling, Metabolism of proteins, Developmental Biology, Intracellular signaling by second messengers, Regulation of FOXO transcriptional activity by acetylation, FOXO-mediated transcription of cell cycle genes, Ub-specific processing proteases, Estrogen-dependent nuclear events downstream of ESR-membrane signaling, Cytokine Signaling in Immune system, Insulin signaling pathway, Drosophila signaling pathways, AKT-mediated inactivation of FOXO1A

Orthologs