PANTHER Gene Information

Gene Symbol(s):

foxo3.L

Organism:

Xenopus laevis

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Gene Name:

Forkhead box protein O3 isoform X1

Gene ID:

foxo3.L

Protein ID:

A0A8J0V937

Persistent Id:

PTN009185324

Alternate Ids:

1069354831(GI)	A0A8J0V937(Synonym)
444992(GeneID)	XP_018117415(refSeq)
A0A8J0V937_XENLA(UniProtKB-ID)
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PANTHER Classification

PANTHER Family:	FORKHEAD BOX PROTEIN O (PTHR45767)
PANTHER Subfamily:	FORKHEAD BOX PROTEIN O3-RELATED (PTHR45767:SF4)
PANTHER GO-slim Molecular Function:	DNA-binding transcription factor activity, RNA polymerase II-specific RNA polymerase II cis-regulatory region sequence-specific DNA binding
PANTHER GO-slim Biological Process:	regulation of transcription by RNA polymerase II
PANTHER GO-slim Cellular Component:	nucleus mitochondrial matrix
PANTHER protein class:	winged helix/forkhead transcription factor

Pathway Categories:

Insulin/IGF pathway-protein kinase B signaling cascade

Forkhead transcription factor

PI3 kinase pathway

FOXO

CCKR signaling map

FOXO3

Interleukin signaling pathway

Forkhead in Rhabdomyosarcoma-like 1

GENE ONTOLOGY DATABASE ANNOTATIONS

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GO MF Complete:	DNA binding, protein kinase binding, chromatin DNA binding, DNA-binding transcription factor activity, RNA polymerase II cis-regulatory region sequence-specific DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, sequence-specific DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific
GO BP Complete:	response to starvation, regulation of DNA-templated transcription, positive regulation of transcription by RNA polymerase II, positive regulation of neuron apoptotic process, regulation of transcription by RNA polymerase II, positive regulation of regulatory T cell differentiation, positive regulation of autophagy, tumor necrosis factor-mediated signaling pathway, positive regulation of DNA-templated transcription, apoptotic process, positive regulation of muscle atrophy, cellular response to oxidative stress, response to fatty acid
GO CC Complete:	nucleus, cytoplasm, mitochondrial matrix, cytosol

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Orthologs

ID	Organism	Type
HUMAN\|HGNC=3821\|UniProtKB=O43524	Homo sapiens	O
PANTR\|Ensembl=ENSPTRG00000018476.6\|UniProtKB=H2R710	Pan troglodytes	O
GORGO\|Ensembl=ENSGGOG00000003517.3\|UniProtKB=G3QLU0	Gorilla gorilla gorilla	O
MACMU\|Ensembl=ENSMMUG00000020369.4\|UniProtKB=F6UMX8	Macaca mulatta	O
MOUSE\|MGI=MGI=1890081\|UniProtKB=Q9WVH4	Mus musculus	O
RAT\|RGD=1309196\|UniProtKB=D3ZBQ1	Rattus norvegicus	O
BOVIN\|Ensembl=ENSBTAG00000011234.3\|UniProtKB=F1N4K5	Bos taurus	O
PIG\|Ensembl=ENSSSCG00000004387.5\|UniProtKB=F1RT23	Sus scrofa	O
HORSE\|Ensembl=ENSECAG00000024499.3\|UniProtKB=A0A9L0QYA0	Equus caballus	O
FELCA\|Ensembl=ENSFCAG00000030227.4\|UniProtKB=M3X8A7	Felis catus	O
CANLF\|Ensembl=ENSCAFG00845009586.1\|UniProtKB=A0A8I3N2V0	Canis lupus familiaris	O
MONDO\|Ensembl=ENSMODG00000017994.4\|UniProtKB=F7B7W4	Monodelphis domestica	O
ORNAN\|Ensembl=ENSOANG00000000768.3\|UniProtKB=F6XNR4	Ornithorhynchus anatinus	O
XENTR\|Xenbase=XB-GENE-945072\|UniProtKB=F7DZ24	Xenopus tropicalis	O
ORYLA\|Ensembl=ENSORLG00000024046.1\|UniProtKB=A0A3B3HQC5	Oryzias latipes	O
DANRE\|ZFIN=ZDB-GENE-050116-1\|UniProtKB=Q5I0F7	Danio rerio	O
ORYLA\|Ensembl=ENSORLG00000013450.2\|UniProtKB=C1K304	Oryzias latipes	O
DANRE\|ZFIN=ZDB-GENE-990708-6\|UniProtKB=Q9W7F8	Danio rerio	O
LEPOC\|Ensembl=ENSLOCG00000016605.1\|UniProtKB=W5NIQ0	lepisosteus oculatus	O
BRAFL\|Gene=LOC118422433\|UniProtKB=A0A9J7LPW6	Branchiostoma floridae	O
STRPU\|EnsemblGenome=LOC585334\|UniProtKB=A0A7M7PE31	Strongylocentrotus purpuratus	O
CAEEL\|WormBase=WBGene00000912\|UniProtKB=O16850	Caenorhabditis elegans	O
CAEBR\|WormBase=WBGene00033715\|UniProtKB=A8XFP9	Caenorhabditis briggsae	O
PRIPA\|EnsemblGenome=WBGene00278355\|UniProtKB=A0A2A6CCE5	Pristionchus pacificus	O
DROME\|FlyBase=FBgn0038197\|UniProtKB=Q95V55	Drosophila melanogaster	O
ANOGA\|EnsemblGenome=AGAP029601\|UniProtKB=Q7PXU5	Anopheles gambiae	O
TRICA\|EnsemblGenome=TC032156\|UniProtKB=A0A139WMU2	Tribolium castaneum	O
IXOSC\|EnsemblGenome=ISCW015581\|UniProtKB=B7P1M4	Ixodes scapularis	O
ASPFU\|EnsemblGenome=AFUA_2G03050\|UniProtKB=Q4WI53	Neosartorya fumigata	O
SCLS1\|EnsemblGenome=SS1G_05834\|UniProtKB=A7EKI7	Sclerotinia sclerotiorum	O