PANTHER Gene Information   
Gene Symbol(s): NOS3
Organism: Gorilla gorilla gorilla
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Gene Name: nitric-oxide synthase (NADPH)
Gene ID: ENSGGOG00000016825.3
Protein ID: G3RKZ4
Persistent Id: PTN002714507
Alternate Ids:
ENSGGOP00000016427(Ensembl_PRO) ENSGGOT00000016892(Ensembl_TRS)
CABD030055980(EMBL) G3RKZ4(Synonym)
XM_019031073(refSeq) ENSGGOG00000016825(Ensembl)
1099291223(GI) G3RKZ4_GORGO(UniProtKB-ID)
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PANTHER Classification
PANTHER Family: NITRIC OXIDE SYNTHASE-RELATED (PTHR19384)
PANTHER Subfamily: NITRIC OXIDE SYNTHASE 3 (PTHR19384:SF66)  
PANTHER GO-slim Molecular Function: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor
carbohydrate derivative binding
flavin adenine dinucleotide binding
PANTHER GO-slim Biological Process: response to hormone
cellular nitrogen compound biosynthetic process
intracellular signaling cassette
response to lipopolysaccharide
positive regulation of lyase activity
positive regulation of cyclase activity
L-amino acid metabolic process
amino acid catabolic process
positive regulation of phosphate metabolic process
positive regulation of nucleobase-containing compound metabolic process
proteinogenic amino acid metabolic process
arginine metabolic process
negative regulation of blood pressure
positive regulation of cellular biosynthetic process
PANTHER GO-slim Cellular Component: cytosol
nucleus
plasma membrane
PANTHER protein class: oxidoreductase
Pathway Categories: VEGF signaling pathway
   endothelial nitric oxide synthase
Angiogenesis
   endothelial nitric oxide synthase
PI3 kinase pathway
   NOS
Endothelin signaling pathway
   endothelial cell nitric oxide synthase
Interleukin signaling pathway
   endothelial nitric oxide synthase

GO MF Complete: arginine binding, calmodulin binding, tetrahydrobiopterin binding, NADP binding, nitric-oxide synthase activity, FMN binding, oxidoreductase activity, metal ion binding, flavin adenine dinucleotide binding, actin monomer binding, heme binding
GO BP Complete: arginine catabolic process, nitric oxide mediated signal transduction, removal of superoxide radicals, negative regulation of blood pressure, response to lipopolysaccharide, nitric oxide biosynthetic process, endothelial cell migration, regulation of systemic arterial blood pressure by endothelin, response to hormone, response to fluid shear stress, positive regulation of blood vessel endothelial cell migration, positive regulation of angiogenesis
GO CC Complete: nucleus, caveola, cytoplasm, cytosol, Golgi apparatus, plasma membrane
Reactome Pathways: -