PANTHER Gene Information   
Gene Symbol(s): Nos3
Organism: Rattus norvegicus
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Gene Name: Nitric oxide synthase 3
Gene ID: 3186
Protein ID: Q62600
Persistent Id: PTN000454034
Alternate Ids:
NOSIII(Synonym) Q68GV6(AltAccession)
U02534(EMBL) 3747079(GI)
CHEMBL1075230(ChEMBL) CAA09494(EMBL-CDS)
1.14.13.39 {ECO:0000250|UniProtKB:P29474}(EC) Nos3{ECO:0000312|RGD:3186}(Symbol)
NOS3_RAT(UniProtKB-ID) NP_068610(refSeq)
24600(GeneID) 3186(RGD)
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PANTHER Classification
PANTHER Family: NITRIC OXIDE SYNTHASE-RELATED (PTHR19384)
PANTHER Subfamily: NITRIC OXIDE SYNTHASE 3 (PTHR19384:SF66)  
PANTHER GO-slim Molecular Function: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor
carbohydrate derivative binding
flavin adenine dinucleotide binding
PANTHER GO-slim Biological Process: response to hormone
cellular nitrogen compound biosynthetic process
intracellular signaling cassette
response to lipopolysaccharide
positive regulation of lyase activity
positive regulation of cyclase activity
L-amino acid metabolic process
amino acid catabolic process
positive regulation of phosphate metabolic process
positive regulation of nucleobase-containing compound metabolic process
proteinogenic amino acid metabolic process
arginine metabolic process
negative regulation of blood pressure
positive regulation of cellular biosynthetic process
PANTHER GO-slim Cellular Component: cytosol
nucleus
plasma membrane
PANTHER protein class: oxidoreductase
Pathway Categories: VEGF signaling pathway
   endothelial nitric oxide synthase
Angiogenesis
   endothelial nitric oxide synthase
PI3 kinase pathway
   NOS
Endothelin signaling pathway
   endothelial cell nitric oxide synthase
Interleukin signaling pathway
   endothelial nitric oxide synthase

GO MF Complete: FMN binding, beta-catenin binding, actin monomer binding, heme binding, arginine binding, scaffold protein binding, calmodulin binding, tetrahydrobiopterin binding, NADP binding, protein binding, actin binding, nitric-oxide synthase activity, metal ion binding, flavin adenine dinucleotide binding, cadherin binding, Hsp90 protein binding, nitric-oxide synthase binding
GO BP Complete: response to hyperoxia, negative regulation of muscle hyperplasia, response to salt, response to fructose, positive regulation of guanylate cyclase activity, retina development in camera-type eye, response to axon injury, negative regulation of potassium ion transport, endothelial cell migration, regulation of the force of heart contraction by chemical signal, positive regulation of angiogenesis, ovulation from ovarian follicle, endocardial cushion morphogenesis, response to hypoxia, in utero embryonic development, negative regulation of calcium ion transport, negative regulation of biomineral tissue development, establishment of localization in cell, aortic valve morphogenesis, nitric oxide mediated signal transduction, response to L-arginine, pulmonary valve morphogenesis, negative regulation of blood pressure, response to organic cyclic compound, regulation of systemic arterial blood pressure by endothelin, response to hormone, response to peptide hormone, arginine catabolic process, response to corticosterone, cellular response to transforming growth factor beta stimulus, positive regulation of gene expression, removal of superoxide radicals, response to magnetism, cellular response to magnesium ion, cellular response to growth factor stimulus, cellular response to cAMP, response to estradiol, lipopolysaccharide-mediated signaling pathway, cellular response to high density lipoprotein particle stimulus, nitric oxide biosynthetic process, response to activity, response to nutrient levels, cellular response to organic cyclic compound, cellular response to low-density lipoprotein particle stimulus, response to cytokine, negative regulation of cell population proliferation, response to amino acid, response to xenobiotic stimulus, vasodilation, response to mechanical stimulus, bone development, potassium ion transport, cellular response to insulin stimulus, response to ethanol, negative regulation of hydrolase activity, cellular response to heat, angiogenesis, calcium ion transport, negative regulation of smooth muscle cell proliferation, blood vessel diameter maintenance, response to metal ion, cellular response to tumor necrosis factor, response to fluid shear stress, lung development, response to carbohydrate, female pregnancy, response to mercury ion, response to peptide, response to nicotine, response to ketone, nitric oxide metabolic process, ventricular septum morphogenesis, positive regulation of blood vessel endothelial cell migration, cellular response to rotenone, regulation of sodium ion transport, cellular response to mechanical stimulus, blood vessel remodeling, response to ultrasound, homeostasis of number of cells within a tissue, smooth muscle hyperplasia, positive regulation of apoptotic process, response to lipopolysaccharide, response to lead ion, regulation of nervous system process, response to erythropoietin
GO CC Complete: nucleus, caveola, cytoskeleton, apical part of cell, cytoplasm, sarcolemma, cytosol, Golgi apparatus, plasma membrane
Reactome Pathways: ROS and RNS production in phagocytes, eNOS activation, VEGFA-VEGFR2 Pathway, Hemostasis, ESR-mediated signaling, Extra-nuclear estrogen signaling, Nitric oxide stimulates guanylate cyclase, NOSIP mediated eNOS trafficking, Metabolism of cofactors, Signal Transduction, Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation, Metabolism of nitric oxide: NOS3 activation and regulation, NOSTRIN mediated eNOS trafficking, VEGFR2 mediated vascular permeability, Metabolism, Immune System, Signaling by Nuclear Receptors, Platelet homeostasis, Metabolism of vitamins and cofactors, Signaling by VEGF, Signaling by Receptor Tyrosine Kinases, Innate Immune System