PANTHER Gene Information   
Gene Symbol(s): NOS3
Organism: Sus scrofa
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Gene Name: Nitric oxide synthase
Gene ID: ENSSSCG00000016450.5
Protein ID: Q7YSG7
Persistent Id: PTN008570820
Alternate Ids:
Q7YSG7_PIG(UniProtKB-ID) AY266137(EMBL)
AAP22420(EMBL-CDS) 30794679(GI)
ENSSSCG00000016450(Ensembl) Q7YSG7(Synonym)
ENSSSCP00000048632(Ensembl_PRO) ENSSSCT00000050205(Ensembl_TRS)
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PANTHER Classification
PANTHER Family: NITRIC OXIDE SYNTHASE-RELATED (PTHR19384)
PANTHER Subfamily: NITRIC OXIDE SYNTHASE 3 (PTHR19384:SF66)  
PANTHER GO-slim Molecular Function: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor
carbohydrate derivative binding
flavin adenine dinucleotide binding
PANTHER GO-slim Biological Process: response to hormone
cellular nitrogen compound biosynthetic process
intracellular signaling cassette
response to lipopolysaccharide
positive regulation of lyase activity
positive regulation of cyclase activity
L-amino acid metabolic process
amino acid catabolic process
positive regulation of phosphate metabolic process
positive regulation of nucleobase-containing compound metabolic process
proteinogenic amino acid metabolic process
arginine metabolic process
negative regulation of blood pressure
positive regulation of cellular biosynthetic process
PANTHER GO-slim Cellular Component: cytosol
nucleus
plasma membrane
PANTHER protein class: oxidoreductase
Pathway Categories: VEGF signaling pathway
   endothelial nitric oxide synthase
Angiogenesis
   endothelial nitric oxide synthase
PI3 kinase pathway
   NOS
Endothelin signaling pathway
   endothelial cell nitric oxide synthase
Interleukin signaling pathway
   endothelial nitric oxide synthase

GO MF Complete: arginine binding, scaffold protein binding, calmodulin binding, tetrahydrobiopterin binding, NADP binding, nitric-oxide synthase activity, FMN binding, metal ion binding, flavin adenine dinucleotide binding, actin monomer binding, heme binding
GO BP Complete: negative regulation of muscle hyperplasia, negative regulation of potassium ion transport, endothelial cell migration, regulation of the force of heart contraction by chemical signal, positive regulation of angiogenesis, ovulation from ovarian follicle, endocardial cushion morphogenesis, potassium ion transport, angiogenesis, in utero embryonic development, calcium ion transport, negative regulation of smooth muscle cell proliferation, blood vessel diameter maintenance, negative regulation of calcium ion transport, negative regulation of biomineral tissue development, establishment of localization in cell, response to fluid shear stress, lung development, aortic valve morphogenesis, nitric oxide mediated signal transduction, pulmonary valve morphogenesis, negative regulation of blood pressure, regulation of systemic arterial blood pressure by endothelin, response to hormone, ventricular septum morphogenesis, positive regulation of blood vessel endothelial cell migration, arginine catabolic process, regulation of sodium ion transport, blood vessel remodeling, homeostasis of number of cells within a tissue, positive regulation of gene expression, smooth muscle hyperplasia, removal of superoxide radicals, lipopolysaccharide-mediated signaling pathway, response to lipopolysaccharide, nitric oxide biosynthetic process, regulation of nervous system process
GO CC Complete: nucleus, caveola, cytosol, Golgi apparatus, plasma membrane
Reactome Pathways: Metabolism, VEGFR2 mediated vascular permeability, eNOS activation, Hemostasis, Signal Transduction, NOSIP mediated eNOS trafficking, Nitric oxide stimulates guanylate cyclase, NOSTRIN mediated eNOS trafficking, Metabolism of nitric oxide: NOS3 activation and regulation, ROS and RNS production in phagocytes, Immune System, Metabolism of vitamins and cofactors, Signaling by VEGF, ESR-mediated signaling, Extra-nuclear estrogen signaling, Platelet homeostasis, VEGFA-VEGFR2 Pathway, Signaling by Receptor Tyrosine Kinases, Innate Immune System, Signaling by Nuclear Receptors, Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation, Metabolism of cofactors